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ALS

From Wikipedia
Amyotrophic lateral sclerosis
Other namesLou Gehrig's disease; Charcot's disease; motor neurone disease (MND)Wijesekera LC, Leigh PN (February 2009). "Amyotrophic lateral sclerosis". Orphanet Journal of Rare Diseases. 3 (4): 3. doi:10.1186/1750-1172-4-3. PMC 2656493. PMID 19192301.{{cite journal}}: CS1 maint: unflagged free DOI (link)
An Magnetic resonance imaging plus increased signal insyd de posterior part of de internal capsule wey fi be tracked to de motor cortex, consistent plus de diagnosis of ALS
SpecialtyNeurology
SymptomsStiff muscles, muscle twitching, gradually worsening weakness
ComplicationsDifficulty insyd speaking, swallowing, shortness of breath
Usual onset50s–60s
CausesUnknown (most), inherited (few)
Diagnostic methodBased for symptoms top
TreatmentNon-invasive ventilation
MedicationRiluzole, edaravone"FDA approves drug to treat ALS". U.S. Food and Drug Administration. 5 May 2017. Archived from the original on 8 May 2017.
PrognosisLife expectancy 2–4 years
Frequency2.6/100,000 per year (Europe)

Amyotrophic lateral sclerosis (ALS), dem sanso know am as motor neurone disease (MND) anaa Lou Gehrig's disease, be a rare, terminal neurodegenerative disorder wey dey result insyd de progressive loss of both upper den lower motor neurons wey normally dey control voluntary muscle contraction.[1] ALS be de most common form of de motor neuron diseases.[2] ALS often dey present insyd ein early stages plus gradual muscle stiffness, twitches, weakness, den wasting.[1] Motor neuron loss typically dey continue til de abilities to eat, speak, move, den, lastly, breathe all be lost.[1] While 15% of people per plus ALS sanso fully dey develop frontotemporal dementia, a 50% dem estimate face at least sam minor difficulties plus thinking den behavior.[3] Dey depend on wich of de aforementioned symptoms wey dey develop first, na dem classify ALS as limb-onset (dey begin plus weakness insyd de arms anaa legs) anaa bulbar-onset (dey begin plus difficulty insyd speaking anaa swallowing).[4]

References

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  1. ↑ 1.0 1.1 1.2 "Amyotrophic Lateral Sclerosis (ALS) Fact Sheet". National Institute of Neurological Disorders and Stroke. Archived from the original on 5 January 2017. Retrieved 22 October 2020.
  2. ↑ "Motor Neuron Diseases Fact Sheet". www.ninds.nih.gov. National Institute of Neurological Disorders and Stroke. Archived from the original on 10 October 2020. Retrieved 27 October 2020.
  3. ↑ van Es MA, Hardiman O, Chio A, Al-Chalabi A, Pasterkamp RJ, Veldink JH, van den Berg LH (November 2017). "Amyotrophic lateral sclerosis". Lancet. 390 (10107): 2084–2098. doi:10.1016/S0140-6736(17)31287-4. PMID 28552366. S2CID 24483077.
  4. ↑ Hardiman O, Al-Chalabi A, Chio A, Corr EM, Logroscino G, Robberecht W, Shaw PJ, Simmons Z, van den Berg LH (October 2017). "Amyotrophic lateral sclerosis" (PDF). Nature Reviews. Disease Primers. 3 (17071): 17071. doi:10.1038/nrdp.2017.71. PMID 28980624. S2CID 1002680. Archived (PDF) from the original on 1 December 2020. Retrieved 20 December 2019.
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