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Amlodipine

From Wikipedia
amlodipine
group of stereoisomers
Stylized nameamLODIPine Edit
Chemical formulaC₂₀H₂₅ClN₂O₅ Edit
Canonical SMILESCCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN Edit
Active ingredient inNorvasc Edit
World Health Organisation international non-proprietary nameamlodipine Edit
Medical condition treatedHypertension, angina pectoris Edit
Physically dey interact plusCalcium voltage-gated channel subunit alpha1 D Edit
Route of administrationoral administration Edit
Pregnancy categoryAustralian pregnancy category C, US pregnancy category C Edit
LiverTox likelihood scoreLiverTox toxicity likelihood category C Edit
Subject has rolecalcium channel blocker, antihypertensive drug, vasodilator agent Edit

Amlodipine, dem sell under de brand name Norvasc among odas, be a calcium channel blocker medication dem use to treat high blood pressure, coronary artery disease (CAD)[1] den variant angina (dem sanso call Prinzmetal angina anaa coronary artery vasospasm, among oda names).[2] Dem dey take am orally (dem swallow by mouth).[1]

Common side effects dey include swelling, feeling tired, abdominal pain, den nausea.[1] Serious side effects fi include low blood pressure anaa heart attack.[1] Whether ein use be safe during pregnancy anaa breastfeeding be unclear.[1] Wen e be used by people plus liver problems, den insyd elderly individuals, doses for be reduced.[1] Amlodipine dey work partly by vasodilation (relaxing de arteries den dey increase dema diameter).[1] E be a long-acting calcium channel blocker of de dihydropyridine type.[1]

Na dem patent amlodipine insyd 1982, wey na dem approve am for medical use insyd 1990.[3] E be on de World Health Organization's List of Essential Medicines.[4] E be available as a generic medication.[1][5] Insyd 2023, na e be de fifth most commonly prescribed medication insyd de United States, plus more dan 68 million prescriptions.[6][7] Insyd Australia, na e be one of de top 10 most prescribed medications between 2017 den 2023.[8]

References

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  1. 1 2 3 4 5 6 7 8 9 "Amlodipine Besylate". Drugs.com. American Society of Hospital Pharmacists. Archived from the original on 4 June 2016. Retrieved 22 July 2016.
  2. ↑ Boden WE (2012). Goldman's Cecil Medicine (24th ed.). Saunders. ISBN 978-1-4377-1604-7. Archived from the original on 26 August 2023. Retrieved 26 August 2023.
  3. ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 465. ISBN 978-3-527-60749-5. Archived from the original on 27 August 2021. Retrieved 1 June 2020.
  4. ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  5. ↑ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.
  6. ↑ "The Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  7. ↑ "Amlodipine Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 17 August 2025.
  8. ↑ "Medicines in the health system". Australian Institute of Health and Welfare. 2 July 2024. Retrieved 30 September 2024.
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