Ankylosing spondylitis
| Subclass of | bone inflammation disease, axial spondyloarthritis, autoimmune disease of musculoskeletal system, spinal disease, disease  |
|---|---|
| Health specialty | rheumatology |
| Symptoms and signs | chronic secondary musculoskeletal pain |
| Described at URL | https://www.nhs.uk/conditions/ankylosing-spondylitis/ |
| External data available at URL | http://www.nanbyou.or.jp/entry/4847 |
| WordLift URL | http://data.medicalrecords.com/medicalrecords/healthwise/ankylosing_spondylitis_2 |
| ICD-9-CM | 720.0 |
| ICPC 2 ID | L88 |
| NCI Thesaurus ID | C84564 |
Ankylosing spondylitis (AS) be a type of arthritis from de disease spectrum of axial spondyloarthritis.[1] De term dey cam from de Greek ankylos wey dey mean crooked, curved anaa rounded, spondylos dey mean vertebra, den -itis wey dey mean inflammation.[2] E be characterized by long-term inflammation of de joints of de spine, typically wer de spine join de pelvis.[2] Lower back pain be a hallmark, buh eye den gastrointestinal problems den arthritis of oda joints sanso fi occur.[2] Joint mobility insyd de affected areas often dey worsen over time, though de progression of symptoms dey vary significantly.[2][3]
Dem dey believe ankylosing spondylitis to involve a combination of genetic den environmental factors.[2] More dan 90% of people affected insyd de UK get a specific human leukocyte antigen dem know as de HLA-B27 antigen, though de genetic correlation dey vary across populations (e.g., 70% of AS patients per insyd Turkey be HLA-B27 positive).[4][5] De underlying mechanism dem believe e be autoimmune anaa autoinflammatory.[6] Diagnosis be based on symptoms plus support from medical imaging den blood tests.[2] AS be a type of seronegative spondyloarthropathy, wey dey mean say tests dey show no presence of rheumatoid factor (RF) antibodies.[2]
Der currently be no cure give AS. Treatments fi include medication, physical therapy, den surgery. Medication therapy dey focus on relieving de pain den oda symptoms of AS, as well as stopping disease progression by counteracting long-term inflammatory processes. Commonly used medications dey include NSAIDs, TNF inhibitors, IL-17 antagonists, den DMARDs. Glucocorticoid injections often be used for acute den localized flare-ups.[7]
About 0.1% to 0.8% of de population be affected, plus onset typically dey occur insyd young adults.[2][8] While men den women equally be affected plus AS, women be more likely to experience inflammation rather dan fusion.[9]
References
[edit | edit source]- ↑ Ivanova, Mariana; Zimba, Olena; Dimitrov, Ivan; Angelov, Alexander K.; Georgiev, Tsvetoslav (2024-09-01). "Axial Spondyloarthritis: an overview of the disease". Rheumatology International (in English). 44 (9): 1607–1619. doi:10.1007/s00296-024-05601-9. ISSN 1437-160X. PMID 38689098.
- 1 2 3 4 5 6 7 8 "Questions and Answers about Ankylosing Spondylitis". NIAMS. June 2016. Archived from the original on 28 September 2016. Retrieved 28 September 2016.
- ↑ "Ankylosing spondylitis". GARD. 9 February 2015. Archived from the original on 2 October 2016. Retrieved 28 September 2016.
- ↑ Sheehan NJ (January 2004). "The ramifications of HLA-B27". Journal of the Royal Society of Medicine. 97 (1): 10–4. doi:10.1177/014107680409700102. PMC 1079257. PMID 14702356.
- ↑ Fırat, Sevde Nur; Yazıcı, Ayten; Yılmazer, Barış; Coşan, Fulya; Savlı, Hakan; Cefle, Ayşe (25 October 2017). "Low frequency of HLA-B27 in ankylosing spondylitis and its relationship with clinical findings in patients from Turkey". European Journal of Rheumatology. 25 (4): 268–271. doi:10.5152/eurjrheum.2017.17015. PMC 5741340. PMID 29308282. Retrieved 4 November 2025.
- ↑ Smith JA (January 2015). "Update on ankylosing spondylitis: current concepts in pathogenesis". Current Allergy and Asthma Reports. 15 (1) 489. doi:10.1007/s11882-014-0489-6. PMID 25447326. S2CID 24623808.
- ↑ Ward, Michael M.; Deodhar, Atul; Gensler, Lianne S.; Dubreuil, Maureen; Yu, David; Khan, Muhammad Asim; Haroon, Nigil; Borenstein, David; Wang, Runsheng; Biehl, Ann; Fang, Meika A.; Louie, Grant; Majithia, Vikas; Ng, Bernard; Bigham, Rosemary (October 2019). "2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis". Arthritis & Rheumatology. 71 (10): 1599–1613. doi:10.1002/art.41042. ISSN 2326-5191. PMC 6764882. PMID 31436036.
- ↑ Khan MA (2009). Ankylosing Spondylitis (in English). Oxford University Press. p. 15. ISBN 978-0-19-536807-9. Archived from the original on 8 September 2017.
- ↑ "Facts and Figures". National Axial Spondyloarthritis Society (in English). Retrieved 2021-01-27.
External links
[edit | edit source]
- Questions and Answers about Ankylosing Spondylitis - US National Institute of Arthritis and Musculoskeletal and Skin Diseases
