Buspirone
| Subclass of | chemical compound  |
|---|---|
| Get use | Medication |
| Stylized name | busPIRone |
| Chemical formula | C₂₁H₃₁N₅O₂ |
| Canonical SMILES | C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4 |
| Active ingredient in | Buspar |
| World Health Organisation international non-proprietary name | buspirone |
| Medical condition treated | anxiety disorder, intellectual disability, neurotic disorder, anxiety |
| Physically dey interact plus | 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine (serotonin) receptor 7 |
| Pregnancy category | Australian pregnancy category B1, US pregnancy category B |
| LiverTox likelihood score | LiverTox toxicity likelihood category E |
| Subject has role | serotonin receptor agonists, anxiolytic |
Buspirone, dem sell under de name Buspar among odas, be an anxiolytic medication dem primarily use for de treatment of generalized anxiety disorder. Unlike benzodiazepines, buspirone no dey produce significant sedation, dependence, anaa withdrawal effects. Ein principal mechanism of action dey involve partial agonism at postsynaptic serotonin 5-HT1A receptors den full agonism at presynaptic 5-HT1A autoreceptors, wich initially dey reduce serotonergic neuron firing. Over time, autoreceptor desensitization dey occur, wey dey lead to increased serotonin release den enhanced serotonergic tone, wich fi contribute to ein clinical efficacy. Buspirone sanso get weak antagonistic effects at dopamine D2, D3, den D4 receptors den α1- den α2-adrenergic receptors.
Buspirone be approved for de management of generalized anxiety disorder. Dem sam times dey use off-label give oda anxiety disorders, depression augmentation, den certain behavioral conditions. Buspirone no be effective as a sedative-hypnotic anaa muscle relaxant wey e no get anticonvulsant properties.
Common side effects of buspirone dey include nausea, headaches, dizziness, den difficulty concentrating.[1][2] Serious side effects fi include movement disorders, serotonin syndrome, den seizures.[2] Ein use insyd pregnancy dey appear to be safe buh e no be well studied, den ein use during breastfeeding no be well studied either.[2][3]
Na dem develop buspirone insyd 1968 wey na dem approve am for medical use insyd de United States insyd 1986.[1][4] E be available as a generic medication.[2] Insyd 2023, na e be de 40th most commonly prescribed medication insyd de United States, plus more dan 15 million prescriptions.[5][6]
References
[edit | edit source]- 1 2 "Buspirone Hydrochloride Monograph for Professionals". Drugs.com.
- 1 2 3 4 British national formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 338. ISBN 978-0-85711-338-2.
- ↑ "Buspirone Pregnancy and Breastfeeding Warnings". Drugs.com.
- ↑ Wilson TK, Tripp J (January 2018). "Buspirone". StatPearls. PMID 30285372.
- ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
- ↑ "Buspirone Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved 18 August 2025.
External links
[edit | edit source]
