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Cerebral palsy

From Wikipedia
cerebral palsy
class of disease
Subclass ofencephalopathy, cerebral degeneration, palsy, disease Edit
Has causeasphyxia neonatorum, encephalopathy, hypoxia Edit
Health specialtyneurology, pediatrics Edit
Symptoms and signstic, toe walking, spasm, muscle rigidity, speech disorder Edit
Medical examinationphysical examination, medical history, medical ultrasonography, magnetic resonance imaging, genetic testing Edit
Possible treatmenttenotomy Edit
Drug or therapy used for treatment(RS)-baclofen, botulinum toxin type A Edit
Hashtagcerebral-palsy Edit
ICD-9-CM343.8, 343.9 Edit
NCI Thesaurus IDC34460 Edit

Cerebral palsy (CP) be a group of movement disorders wey dey appear insyd early kiddie time.[1] Signs den symptoms dey vary among people den over time,[1][2] buh dey include poor coordination, stiff muscles, weak muscles, den tremors.[1] Der fi be problems plus sensation, vision, hearing, den speech.[1] Often, babies plus cerebral palsy no dey roll over, sit, crawl anaa walk as early as oda kiddies.[1] Oda symptoms fi include seizures den problems plus thinking anaa reasoning. While symptoms fi get more noticeable over de first years of life, underlying problems no dey worsen over time.[1]

Cerebral palsy be caused by abnormal development anaa damage to de parts of de brain wey dey control movement, balance, den posture.[1][3] Most often, de problems dey occur during pregnancy, buh fi occur during childbirth anaa shortly afterwards.[1] Often, de cause be unknown.[1] Risk factors dey include preterm birth, dem be a twin, certain infections anaa exposure to methylmercury during pregnancy, a difficult delivery, den head trauma during de first few years of life.[1] A study dem publish insyd 2024 dey suggest dat inherited genetic causes dey play a role insyd 25% of cases,[4] wer na formerly dem believe say na 2% of cases be genetically determined.[5]

Sub-types be classified, dem base on de specific problems present.[1] For example, those plus stiff muscles get spastic cerebral palsy, poor coordination insyd locomotion get ataxic cerebral palsy, den writhing movements get dyskinetic cerebral palsy.[6] Diagnosis dey base on de kiddie ein development.[1] Blood tests den medical imaging fi be used to rule out oda possible causes.[1]

Some causes of CP be preventable thru immunization of de mommie, den efforts to prevent head injuries insyd kiddies such as improved safety. Der be no known cure give CP, buh supportive treatments, medication den surgery fi help individuals.[1] Dis fi include physical therapy, occupational therapy den speech therapy.[1] Na mouse NGF show to improve outcomes[7][8] wey na e be available insyd China since 2003.[8] Medications such as diazepam, baclofen den botulinum toxin fi help relax stiff muscles.[1][9][10] Surgery fi include lengthening muscles den cutting overly active nerves.[1] Often, external braces den Lycra splints den oda assistive technology be helpful plus mobility.[1][11] Sam affected kiddies fi achieve near normal adult lives plus appropriate treatment.[1] While dem frequently use alternative medicines, der be no evidence to support dema use.[1] Dem dey examine potential treatments, wey dey include stem cell therapy.[1] However, dem dey require more research to determine if e be effective den safe.[1]

Cerebral palsy be de most common movement disorder insyd kiddies,[12] wey dey occur insyd about 2.1 per 1,000 live births.[13] Na dem document am thru out history, plus de first known descriptions dey occur insyd de work of Hippocrates insyd de 5th century BCE.[14] Na extensive study begin insyd de 19th century by William John Little, after whom na dem call spastic diplegia "Little's disease".[14] Na William Osler name am "cerebral palsy" from de German zerebrale Kinderlähmung (cerebral child-paralysis).[15] Historical literature den artistic representations wey dey reference symptoms of cerebral palsy dey indicate say na dem recognize de condition insyd antiquity, wey dey characterize am as an "old disease".[16]

References

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  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 "Cerebral Palsy | National Institute of Neurological Disorders and Stroke". www.ninds.nih.gov (in English). Retrieved 2025-12-07.
  2. Haak P, Lenski M, Hidecker MJ, Li M, Paneth N (October 2009). "Cerebral palsy and aging". Developmental Medicine and Child Neurology. 51 (4): 16–23. doi:10.1111/j.1469-8749.2009.03428.x. PMC 4183123. PMID 19740206.
  3. "Cerebral Palsy: Overview". National Institutes of Health. Archived from the original on 15 February 2017. Retrieved 21 February 2017.
  4. Rosenbaum, Peter; Paneth, Nigel; Leviton, Alan; Goldstein, Murray; Bax, Martin; Damiano, Diane; Dan, Bernard; Jacobsson, Bo (May 2024). "A report: the definition and classification of cerebral palsy April 2006". Developmental Medicine and Child Neurology. Supplement. 109: 8–14. ISSN 0419-0238. PMID 17370477.
  5. "Entry - ^603513 - MOVED TO 619026 AND 612900 - OMIM - (OMIM.ORG)". omim.org. Retrieved 2025-12-07.
  6. Rosenbaum P, Paneth N, Leviton A, Goldstein M, Bax M, Damiano D, Dan B, Jacobsson B (February 2007). "A report: the definition and classification of cerebral palsy April 2006". Developmental Medicine and Child Neurology. Supplement. 109: 8–14. doi:10.1111/j.1469-8749.2007.tb12610.x. PMID 17370477. S2CID 24504486.
  7. 赵会玲; 冯欢欢; 李晓捷; 庞伟 (2019-08-20). "注射用鼠神经生长因子联合康复训练治疗脑性瘫痪患儿的临床疗效". 中华实用儿科临床杂志 (in Chinese). 34 (16). doi:10.3760/cma.j.i. ISSN 2095-428X. Archived from the original on 2025-10-04.
  8. 1 2 Zhao, Meng; Li, Xiao-Yan; Xu, Chun-Ying; Zou, Li-Ping (May 2015). "Efficacy and safety of nerve growth factor for the treatment of neurological diseases: a meta-analysis of 64 randomized controlled trials involving 6,297 patients". Neural Regeneration Research. 10 (5): 819–828. doi:10.4103/1673-5374.156989. ISSN 1673-5374. PMC 4468778. PMID 26109961.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  9. Farag, Sara M.; Mohammed, Manal O.; El-Sobky, Tamer A.; ElKadery, Nadia A.; ElZohiery, Abeer K. (March 2020). "Botulinum Toxin A Injection in Treatment of Upper Limb Spasticity in Children with Cerebral Palsy: A Systematic Review of Randomized Controlled Trials". JBJS reviews. 8 (3): e0119. doi:10.2106/JBJS.RVW.19.00119. ISSN 2329-9185. PMC 7161716. PMID 32224633.
  10. Blumetti, Francesco C.; Belloti, João Carlos; Tamaoki, Marcel Js; Pinto, José A. (2019-10-08). "Botulinum toxin type A in the treatment of lower limb spasticity in children with cerebral palsy". The Cochrane Database of Systematic Reviews. 10 (10): CD001408. doi:10.1002/14651858.CD001408.pub2. ISSN 1469-493X. PMC 6779591. PMID 31591703.
  11. Elliott CM, Reid SL, Alderson JA, Elliott BC (2011-02-01). "Lycra arm splints in conjunction with goal-directed training can improve movement in children with cerebral palsy". NeuroRehabilitation. 28 (1): 47–54. doi:10.3233/nre-2011-0631. PMID 21335677.
  12. "How many people are affected?". National Institutes of Health. 5 September 2014. Archived from the original on 2 April 2015. Retrieved 4 March 2015.
  13. Oskoui, Maryam; Coutinho, Franzina; Dykeman, Jonathan; Jetté, Nathalie; Pringsheim, Tamara (2013). "An update on the prevalence of cerebral palsy: a systematic review and meta-analysis". Developmental Medicine & Child Neurology (in English). 55 (6): 509–519. doi:10.1111/dmcn.12080. ISSN 1469-8749.
  14. 1 2 Panteliadis, Christos; Panteliadis, Panos; Vassilyadi, Frank (April 2013). "Hallmarks in the history of cerebral palsy: from antiquity to mid-20th century". Brain & Development. 35 (4): 285–292. doi:10.1016/j.braindev.2012.05.003. ISSN 1872-7131. PMID 22658818.
  15. "Cerebral Palsy Association of the Philippines". cpapinfo.com. Archived from the original on 2016-12-20. Retrieved 2025-12-07.
  16. Chen, Shao-jun; Wang, Xiu-li (2007–2008). "[Retrospect of the history of cerebral palsy cognition]". Zhonghua Yi Shi Za Zhi (Beijing, China: 1980). 38 (3): 158–162. ISSN 0255-7053. PMID 24915654.
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