Diclofenac
| Subclass of | chemical compound  |
|---|---|
| Get use | Medication |
| Chemical formula | C₁₄H₁₁Cl₂NO₂ |
| Canonical SMILES | C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl |
| World Health Organisation international non-proprietary name | diclofenac |
| Legal status (medicine) | boxed warning |
| Pregnancy category | Australian pregnancy category C, US pregnancy category C |
| LiverTox likelihood score | LiverTox toxicity likelihood category A |
| Get characteristic | bitterness |
| Subject has role | cyclooxygenase inhibitors, non-steroidal anti-inflammatory drug, non-opioid analgesic |
| MCN code | 2922.49.64 |
Diclofenac, dem sell under de brand name Voltaren among odas, be a nonsteroidal anti-inflammatory drug (NSAID) dem use to treat pain den inflammatory diseases such as gout.[1][2] Dem fi take am orally (dem swallow by mouth), dem insert rectally as a suppository, dem inject intramuscularly, dem inject intravenously, dem apply to de skin topically, anaa thru eye drops.[2][3][4] Improvements insyd pain dey last up to eight hours.[2] E sanso be available as de fixed-dose combination diclofenac/misoprostol (Arthrotec) to help protect de stomach; however, proton pump inhibitors such as omeprazole typically be first-line since dem be at least as effective as misoprostol, buh plus better tolerability.[5][6][7]
Common side effects dey include abdominal pain, gastrointestinal bleeding, nausea, dizziness, headache, den swelling.[2] Serious side effects fi include heart disease, stroke, kidney problems, den stomach ulceration.[2][6] Ein use no be recommended insyd de third trimester of pregnancy.[2] E likely be safe during breastfeeding.[6] Dem dey believe Diclofenac to work by decreasing de production of prostaglandins, like oda drugs insyd dis class.[8]
Insyd 2023, na e be de 73rd most commonly prescribed medication insyd de United States, plus more dan 9 million prescriptions.[9][10] E be available as ein acid anaa insyd two salts, as either diclofenac sodium anaa potassium.[6]
References
[edit | edit source]- ↑ "DailyMed - VOLTAREN ARTHRITIS PAIN- diclofenac sodium gel VOLTAREN ARTHRITIS PAIN- diclofenac sodium kit". dailymed.nlm.nih.gov. Retrieved 2026-01-10.
- 1 2 3 4 5 6 "Diclofenac epolamine Monograph for Professionals". Drugs.com. Retrieved 18 February 2024.
- ↑ Chung CH (2017). "The use of Injectable Nonsteroidal Anti-Inflammatory Drugs in Local Accident & Emergency Practice". Hong Kong Journal of Emergency Medicine. 9 (2): 65–71. doi:10.1177/102490790200900201. S2CID 74032271.
- ↑ "Diclofenac Ophthalmic". medlineplus.gov. 2016-07-15. Retrieved 2024-10-08.
- ↑ "Arthrotec- diclofenac sodium and misoprostol tablet, film coated". DailyMed. 16 August 2023. Retrieved 13 October 2024.
- 1 2 3 4 British national formulary: BNF 74 (74 ed.). British Medical Association. 2017. pp. 1033–1035. ISBN 978-0-85711-298-9.
- ↑ Tai FW, McAlindon ME (March 2021). "Non-steroidal anti-inflammatory drugs and the gastrointestinal tract". Clinical Medicine. 21 (2): 131–134. doi:10.7861/clinmed.2021-0039. PMC 8002800. PMID 33762373.
- ↑ Mosby's Drug Reference for Health Professions. Elsevier Health Sciences. 2017. p. 398. ISBN 978-0-323-56682-7.
- ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
- ↑ "Diclofenac Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved 18 August 2025.
External links
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