Duloxetine
| Subclass of | (RS)-duloxetine  |
|---|---|
| Get use | Medication |
| Stylized name | DULoxetine |
| Stereoisomer of | (R)-duloxetine |
| Chemical formula | C₁₈H₁₉NOS |
| Canonical SMILES | CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32 |
| Isomeric SMILES | CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32 |
| World Health Organisation international non-proprietary name | duloxetine |
| Physically dey interact plus | 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 6, Solute carrier family 6 member 2, solute carrier family 6 member 4 |
| Legal status (medicine) | boxed warning |
| Pregnancy category | Australian pregnancy category B3, US pregnancy category C |
| LiverTox likelihood score | LiverTox toxicity likelihood category B |
| Subject has role | selective serotonin reuptake inhibitor, adrenergic uptake inhibitors, serotonin–norepinephrine reuptake inhibitor |
Duloxetine, dem sell under de brand name Cymbalta among odas,[1] be a medication dem use to treat major depressive disorder, generalized anxiety disorder, obsessive–compulsive disorder, fibromyalgia, neuropathic pain, central sensitization, den oda types of chronic pain.[2][3] Dem dey take am by mouth.[2]
Duloxetine be a serotonin–norepinephrine reuptake inhibitor (SNRI).[4] De precise mechanism give ein antidepressant den anxiolytic effects no be known.[2]
Common side effects dey include dry mouth, nausea, constipation, loss of appetite, drowsiness, sexual problems, den increased sweating.[5] Severe side effects dey include an increased risk of suicide, serotonin syndrome, mania, den liver problems.[2] Antidepressant withdrawal syndrome fi occur if dem stop.[2] Ein use during de later part of pregnancy fi increase de risk of bleeding anaa cause complications for de fetus.[5]
Na dem approve duloxetine for medical use insyd de United States[2][6] den de European Union insyd 2004.[7][8] E be available as a generic medication.[4] Insyd 2023, na e be de 31st most commonly prescribed medication insyd de United States, plus more dan 18 million prescriptions.[9][10]
References
[edit | edit source]- ↑ "Duloxetine". Drugs.com. Archived from the original on 29 September 2018. Retrieved 24 December 2018.
- 1 2 3 4 5 6 "Duloxetine". Monograph. The American Society of Health-System Pharmacists. Archived from the original on 26 November 2018. Retrieved 24 December 2018.
- ↑ "Medications for OCD". International OCD Foundation (in American English). Archived from the original on 27 January 2024. Retrieved 25 February 2024.
- 1 2 British national formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 364–365. ISBN 978-0-85711-338-2.
- 1 2 "Duloxetine: Uses, Side Effects, Dosage, Warnings". Drugs.com (in English). Retrieved 30 May 2025.
- ↑ "Drug Approval Package: Cymbalta (Duloxetine Hydrochloride) NDA #021427". U.S. Food and Drug Administration (FDA). 24 December 1999. Archived from the original on 24 September 2020. Retrieved 29 September 2020.
- ↑ "Cymbalta EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 20 October 2020. Retrieved 30 September 2020.
- ↑ "Yentreve EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 24 September 2020. Retrieved 30 September 2020.
- ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
- ↑ "Duloxetine Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 13 August 2025.
External links
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