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Dupuytren's contracture

From Wikipedia
Dupuytren's contracture
disease
Subclass offibromatosis, contracture, superficial fibromatosis, flexion contracture of finger Edit
Dem name afterGuillaume Dupuytren Edit
Health specialtyorthopedics Edit
NCI Thesaurus IDC3469 Edit

Dupuytren's contracture (dem sanso call Dupuytren's disease, Morbus Dupuytren, Palmar fibromatosis den historically as Viking disease anaa Celtic hand) be a condition insyd wich one anaa more fingers cam permanently be bent insyd a flexed position.[1] Dem name am after Guillaume Dupuytren, wey na first describe de underlying mechanism of action, wey be followed by de first successful operation insyd 1831 den publication of de results insyd The Lancet insyd 1834.[2] E usually dey begin as small, hard nodules just under de skin of de palm,[1] then dey worsen over time til de fingers no longer fi be fully straightened. While typically no be painful, sam aching anaa itching, anaa pain,[3] fi be present.[1] De ring finger follow by de little and middle fingers be most commonly affected.[1] E fi affect one anaa both hands.[4] De condition fi interfere plus activities such as preparing chow, writing, putting de hand insyd a tight pocket, putting on gloves, anaa shaking hands.[1]

Der be no single cause for Dupuytren's contracture, buh der be chaw risk factors wey be associated plus an increased risk of developing am.[5] De cause be unknown buh fi get a genetic component.[6] Risk factors dey include family history, alcoholism, smoking, thyroid problems, liver disease, diabetes, previous hand trauma, den epilepsy.[1][6] De underlying mechanism dey involve de formation of abnormal connective tissue within de palmar fascia.[1] Diagnosis usually dey base on physical examination.[6] Insyd sam cases imaging fi be indicated.[4]

Insyd 2020, na de World Health Organization reclassify Dupuytren's (dem term palmar-type fibromatosis) as a specific type of tumor insyd de category of intermediate (locally aggressive) fibroblastic den myofibroblastic tumors.[7]

Initial treatment be typically plus cortisone dem inject into de affected area, occupational therapy, den physical therapy.[6] Among those wey worsen, clostridial collagenase injections anaa surgery fi be tried.[6][8] Radiation therapy fi be used to treat dis condition.[9] Na de Royal College of Radiologists (RCR) Faculty of Clinical Oncology conclude say radiotherapy be effective insyd early stage disease wich na progress within de last 6 to 12 months. De condition fi recur at sam time after treatment;[6] e then sanso fi be treated. E be easier to treat wen de amount of finger bending be more mild.[4]

Na dem once believe say Dupuytren's most often occur insyd white males over de age of 50[1] wey na dem think to be rare among Asians den Africans.[10] E sam times be called "Viking disease," since na e often be recorded among those of Nordic descent.[10] Insyd Norway, na about 30% of men over 60 years old get de condition, while insyd de United States about 5% of people be affected at sam point insyd time.[1] Insyd de United Kingdom, na about 20% of people over 65 get sam form of de disease.[10]

More recent den wider studies dey show de highest prevalence insyd Africa (17 percent) den Asia (15 percent).[11]

Notable cases

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  • Chelsea Handler (born 1975), American comedian, actress den writer[12][13]
  • Tim Herron (born 1970), American golfer[14]
  • Prince Joachim of Denmark (born 1969)[15]
  • Joanne Harris (born 1964), British author[16]
  • Tommy Lee (born 1962), American drummer[17]
  • Ally McCoist (born 1962), Scottish footballer[18]
  • Jonathan Agnew (born 1960), English cricketer[19]
  • John Elway (born 1960), American football player[20]
  • Nanci Griffith (1953–2021), American singer, guitarist, den songwriter[21][22]
  • Bill Murray (born 1950), American actor den comedian[23]
  • Bill Nighy (born 1949), British actor[24]
  • Mitt Romney (born 1947), American politician[12]
  • Misha Dichter (born 1945), American pianist[25]
  • José Feliciano (born 1945), Puerto Rican musician, singer den composer[26]
  • Bill Frindall (1939–2009), English cricket player den statistician, wey na dem amputate a finger[27]
  • David McCallum (1933–2023), Scottish/British actor den musician[28]
  • Paul Newman (1925–2008), American actor den film director[12]
  • Margaret Thatcher (1925–2013), Prime Minister of de United Kingdom[29]
  • Ronald Reagan (1911–2004), American President den actor[29]
  • Andrew Wyeth (1917–2009), American visual artist[12]
  • Frank Sinatra (1915–1998), American singer, actor, den producer[30]
  • Samuel Beckett (1906–1989), Irish novelist, poet and playwright[12]
  • Max Planck (1858–1947), German theoretical physicist den Nobel Prize laureate[12]
  • Dave Mustaine (born 1961), American guitarist[31]

References

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  1. 1 2 3 4 5 6 7 8 9 "Dupuytren contracture". Genetics Home Reference (in English). US: United States National Library of Medicine, National Institutes of Health. 1 April 2019. Archived from the original on 13 May 2017.
  2. ↑ Hart, M. G.; Hooper, G. (2005). "Clinical associations of Dupuytren's disease". Postgraduate Medical Journal. 81 (957): 425–28. doi:10.1136/pgmj.2004.027425. PMC 1743313. PMID 15998816.
  3. ↑ von Campe, A.; Mende, K.; Omaren, H.; Meuli-Simmen, C. (2012). "Painful Nodules and Cords in Dupuytren Disease". The Journal of Hand Surgery. 37 (7): 1313–1318. doi:10.1016/j.jhsa.2012.03.014. PMID 22560560.
  4. 1 2 3 The American Society for Surgery of the Hand (2021). "Dupuytren's Contracture". HandCare: The Upper Extremity Expert. Retrieved July 28, 2022.
  5. ↑ "Dupuytrens Symptoms". Dupuytren's (in British English). Retrieved 2025-09-10.
  6. 1 2 3 4 5 6 "Dupuytren's Contracture". National Organization for Rare Disorders. 2005. Archived from the original on 10 September 2017. Retrieved 3 June 2017.
  7. ↑ Sbaraglia M, Bellan E, Dei Tos AP (April 2021). "The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives". Pathologica. 113 (2): 70–84. doi:10.32074/1591-951X-213. PMC 8167394. PMID 33179614.
  8. ↑ Brazzelli, M; Cruickshank, M; Tassie, E; McNamee, P; Robertson, C; Elders, A; Fraser, C; Hernandez, R; Lawrie, D; Ramsay, C (October 2015). "Collagenase clostridium histolyticum for the treatment of Dupuytren's contracture: systematic review and economic evaluation". Health Technology Assessment. 19 (90): 1–202. doi:10.3310/hta19900. PMC 4781188. PMID 26524616.
  9. ↑ Kadhum, M; Smock, E; Khan, A; Fleming, A (1 March 2017). "Radiotherapy in Dupuytren's disease: a systematic review of the evidence". The Journal of Hand Surgery, European Volume. 42 (7): 689–92. doi:10.1177/1753193417695996. PMID 28490266. S2CID 206785758. On balance, radiotherapy should be considered an unproven treatment for early Dupuytren's disease due to a scarce evidence base and unknown long-term adverse effects.
  10. 1 2 3 Hart, M. G.; Hooper, G. (2005). "Clinical associations of Dupuytren's disease". Postgraduate Medical Journal. 81 (957): 425–28. doi:10.1136/pgmj.2004.027425. PMC 1743313. PMID 15998816.
  11. ↑ Ruettermann M, Hermann RM, Khatib-Chahidi K, Werker PM (November 2021). "Dupuytren's Disease-Etiology and Treatment". Dtsch Ärztebl Int. 118 (46): 781–788. doi:10.3238/arztebl.m2021.0325. PMC 8864671. PMID 34702442.
  12. 1 2 3 4 5 6 "Local MD Will Speak on Crippling Hand Disease Which Affects Many Seniors," Sun-Sentinel, July 15, 2014
  13. ↑ Dana Leigh Smith: Hand Trouble? It Might Be THIS, womenshealthmag.com, May 8, 2013
  14. ↑ Helen Ross (November 6, 2018). "Herron dealing with early stages of Dupuytren's contracture". PGATour.
  15. ↑ "Joachim opereret for krumme fingre". HER&NU. March 17, 2013. Archived from the original on October 29, 2013.
  16. ↑ New Treatment Straightens Bent Fingers without Surgery Archived 2022-08-14 at the Wayback Machine, springgroup.org
  17. ↑ "Tommy Lee Reveals He Can Twirl Drumsticks Again in Update After Hand Surgery: 'I Have My Life Back'". Peoplemag.
  18. ↑ "Ally McCoist reveals incurable hand condition". BBC.
  19. ↑ Jonathan Agnew: How my Viking ancestry nearly cost me my hands, telegraph.co.uk, 27 July 2017
  20. ↑ Chelsea Howard (August 22, 2019). "Broncos' John Elway opens up about 15-year battle with debilitating hand condition". Sporting News. Archived from the original on August 23, 2019. Retrieved August 23, 2019.
  21. ↑ Belcher, David (February 29, 2012). "Politics Sung With a Texas Kick". The New York Times. Archived from the original on August 15, 2021.
  22. ↑ Sweeting, Adam (August 15, 2021). "Nanci Griffith obituary". The Guardian. Archived from the original on August 16, 2021.
  23. ↑ Dupuytren Disease and the Dupuytren Research Group Archived 2022-06-19 at the Wayback Machine, dupuytrens.org
  24. ↑ Farndale, Nigel (February 8, 2015). "Bill Nighy: 'I'm greedy for beauty'". The Guardian. Archived from the original on March 23, 2017. Retrieved March 23, 2017.
  25. ↑ Pollack, Andrew (March 15, 2010). "Triumph for Drug to Straighten Clenched Fingers". The New York Times. Archived from the original on March 18, 2010.
  26. ↑ Joe Bosso: José Feliciano on the Enduring Ecstasies of Guitar Playing, guitarplayer.com, May 8, 2020
  27. ↑ Jonathan Agnew, Aggers' Ashes (London, 2011), page 103
  28. ↑ David McCallum, imdb.com
  29. 1 2 Drug Approved to Treat Hand-Crippling Syndrome, Delthia Ricks, Chicago Tribune, March 17, 2010.
  30. ↑ Leigh, Spencer (2015). Frank Sinatra: An Extraordinary Life. McNidder and Grace Limited. ISBN 978-0-85716-088-1. Retrieved 2020-01-18.
  31. ↑ "MEGADETH's DAVE MUSTAINE Opens Up About His Battle With Hand Condition Known As Dupuytren's Contracture". BLABBERMOUTH.NET. December 24, 2025.
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