Epigenetics of autism

epigenetics of autism

causes of autism

Epigenetics of autism be de study of heritable changes insyd gene expression wey no dey alter de genetic code buh fi contribute to de development den variability of autism spectrum disorder (ASD). Autism dey tend e get a strong correlation plus genetics along plus oda factors. Epigenetics generally dey refer to de ways in wich chromatin structure be altered to affect gene expression, wich dey include mechanisms such as cytosine regulation den post-translational modifications of histones. De connection between epigenetics den autism no fully be known. Of de 215 genes wey dey contribute, to sam extent insyd autism, dem find 42 to be involved insyd epigenetic modification of gene expression.

Diagnosis dey base on observation of behavior den development. Chaw, especially girls den those wey get fewer social difficulties, fi be misdiagnosed plus oda conditions. Males be diagnosed plus autism four to five times more often dan females. De reasons give dis remain predominantly unclear, buh current hypotheses dey include a higher testosterone level insyd utero, different presentations of characteristics insyd females (wey dey lead to misdiagnosis anaa underdiagnosis) dem compare to males, den gender bias. Clinical assessment of kiddies fi involve a variety of individuals, wey dey include de caregiver(s), de kiddie, den a core team of professionals (pediatricians, child psychiatrists, speech-and-language therapists den clinical/educational psychologists). For adult diagnosis, clinicians dey identify neurodevelopmental history, behaviors, difficulties insyd communication, limited interests den problems insyd education, employment, den social relationships. Challenging behaviors fi be assessed plus functional analysis to identify de triggers wey dey cause dem. De sex den gender disparity insyd autism diagnostics dey require further research in terms of adding diagnosis specifiers as well as female-oriented examples, wich fi be masked thru camouflaging behaviors. Camouflaging be defined as a coping mechanism dem use insyd social situations, wey dey consist of individuals wey dey pretend to be oda people widout any communication difficulties. Secof camouflaging den oda societal factors, autistic females be more likely to be diagnosed late anaa plus a different mental health concern. In general, e be critical for people to understand say de female autism phenotype be less noticeable, especially wen dem be present as "higher functioning" dan oda autistic people. Lastly, secof de imbalance insyd sexes wey dey participate insyd autism studies, de literature potentially be biased towards de ways wey e dey present insyd male individuals.