Escitalopram
| Subclass of | (RS)-citalopram  |
|---|---|
| Get use | Medication, chemical probe |
| Stereoisomer of | (R)-citalopram |
| Chemical formula | C₂₀H₂₁FN₂O |
| Canonical SMILES | CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F |
| Isomeric SMILES | CN(C)CCC[C@@]1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F |
| Active ingredient in | Lexapro, Citoles, Cipralex |
| World Health Organisation international non-proprietary name | escitalopram |
| Found insyd taxon | Homo sapiens |
| Physically dey interact plus | solute carrier family 6 member 4 |
| Legal status (medicine) | boxed warning |
| Pregnancy category | Australian pregnancy category C, US pregnancy category C |
| Subject has role | selective serotonin reuptake inhibitor |
Escitalopram ( /ˌɛsəˈtæləˌpræm/ eh-sə-TA-lə-pram), dem sell under de brand names Lexapro den Cipralex, among odas, be an antidepressant medication of de selective serotonin reuptake inhibitor (SSRI) class.[1] Dem mainly used am to treat major depressive disorder,[1] generalized anxiety disorder,[1] panic disorder, obsessive–compulsive disorder (OCD), den social anxiety disorder. Dem dey take escitalopram by mouth.[1] For commercial use, e be formulated as an oxalate salt exclusively.
Common side effects dey include headache, nausea, sexual problems, mild sedation, den trouble sleeping.[1] More serious side effects fi include suicidal thoughts insyd people up to de age of 24 years.[1] E be unclear if ein use during pregnancy anaa breastfeeding be safe.[2] Escitalopram be de (S)-enantiomer of citalopram (wich dey exist as a racemate), hence de name es-citalopram.[1]
Na dem approve escitalopram for medical use insyd de United States insyd 2002.[1] Escitalopram rarely be replaced by twice de dose of citalopram; escitalopram be safer den more effective.[3] E dey on de World Health Organization's List of Essential Medicines.[4] Insyd 2023, na e be de second most prescribed antidepressant den fourteenth most commonly prescribed medication insyd de United States, plus more dan 37 million prescriptions.[5][6] Insyd Australia, na e be one of de top 10 most prescribed medications between 2017 den 2023.[7]
Oda first-line SSRIs wey get similar results dey include sertraline, paroxetine, den fluoxetine, among odas.
References
[edit | edit source]- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 "X". The American Society of Health-System Pharmacists. Archived from the original on 29 December 2017. Retrieved 28 December 2017.
- ↑ "Escitalopram (Lexapro) Use During Pregnancy". Drugs.com. Archived from the original on 31 December 2017. Retrieved 31 December 2017.
- ↑ "Protocol for switching patients from escitalopram to citalopram". NHS. 2015. Archived from the original on 10 August 2020. Retrieved 13 February 2018.
- ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
- ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
- ↑ "Escitalopram Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 12 August 2025.
- ↑ "Medicines in the health system". Australian Institute of Health and Welfare. 2 July 2024. Retrieved 30 September 2024.
External links
[edit | edit source]
- Harris G (1 September 2009). "A Peek at How Forest Laboratories Pushed Lexapro". The New York Times.
- Pages using the Phonos extension
- CS1:Vancouver names with accept markup
- Commons category link from Wikidata
- 4-Fluorophenyl compounds
- Antidepressants
- CYP2D6 inhibitors
- Dimethylamino compounds
- Drugs wey AbbVie develop
- Enantiopure drugs
- Isobenzofurans
- Nitriles
- Selective serotonin reuptake inhibitors
- Sigma agonists
- Translated from MDWiki