Ezetimibe
| Subclass of | (3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone  |
|---|---|
| Get use | Medication |
| Chemical formula | C₂₄H₂₁F₂NO₃ |
| Canonical SMILES | C1=CC(=CC=C1C2C(C(=O)N2C3=CC=C(C=C3)F)CCC(C4=CC=C(C=C4)F)O)O |
| Isomeric SMILES | C1=CC(=CC=C1[C@@H]2[C@H](C(=O)N2C3=CC=C(C=C3)F)CC[C@@H](C4=CC=C(C=C4)F)O)O |
| Active ingredient in | Zetia |
| World Health Organisation international non-proprietary name | ezetimibe |
| Medical condition treated | familial hypercholesterolemia, familial hypercholesterolemia, lipedema, rare dyslipidemia |
| Significant drug interaction | fenofibrate |
| Physically dey interact plus | NPC1 like intracellular cholesterol transporter 1 |
| Route of administration | oral administration |
| Legal status (medicine) | boxed warning |
| Pregnancy category | Australian pregnancy category C, US pregnancy category C |
| LiverTox likelihood score | LiverTox toxicity likelihood category C |
| Subject has role | anticholesteremic agents, lipid regulating agents |
Ezetimibe, dem sell under de brand name Zetia among odas, be a medication dem use to treat high blood cholesterol den certain oda lipid abnormalities.[1][2] Generally e be used togeda plus dietary changes den a statin.[3] Alone, e be less preferred dan a statin.[2] Dem dey take am by mouth.[2] E sanso be available insyd de fixed-dose combinations ezetimibe/simvastatin,[4] ezetimibe/atorvastatin,[5] ezetimibe/rosuvastatin,[2][6] den ezetimibe/bempedoic acid.[7]
De most commonly reported adverse events dey include upper respiratory tract infections, joint pain, diarrhea, den tiredness.[2] Serious side effects fi include anaphylaxis, liver problems, depression, den muscle breakdown.[2][8] Ein use insyd pregnancy den breastfeeding be of unclear safety.[9] Ezetimibe dey work by decreasing cholesterol absorption insyd de intestines.[8]
Na dem approve ezetimibe for medical use insyd de United States insyd 2002.[2] E be available as a generic medication.[8] Insyd 2023, e be de 70th most commonly prescribed medication insyd de United States, plus more dan 9 million prescriptions.[10][11]
References
[edit | edit source]- ↑ "DailyMed - ZETIA- ezetimibe tablet". dailymed.nlm.nih.gov. Retrieved 2026-05-09.
- 1 2 3 4 5 6 7 "Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.
- ↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.
- ↑ "Vytorin- ezetimibe and simvastatin tablet". DailyMed. 1 June 2022. Archived from the original on 14 August 2022. Retrieved 13 August 2022.
- ↑ "Liptruzet (ezetimibe and atorvastatin) tablets for oral useInitial U.S. Approval: 2013". DailyMed. 30 September 2016. Archived from the original on 14 August 2022. Retrieved 13 August 2022.
- ↑ "Roszet- rosuvastatin and ezetimibe tablet Roszet (- rosuvastatin and ezetimibe tablet". DailyMed. 15 September 2021. Archived from the original on 14 August 2022. Retrieved 13 August 2022.
- ↑ "Nexlizet- bempedoic acid and ezetimibe tablet, film coated". DailyMed. 24 September 2021. Retrieved 13 August 2022.
- 1 2 3 British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.
- ↑ "Ezetimibe (Zetia) Use During Pregnancy". Drugs.com. Archived from the original on 13 April 2019. Retrieved 13 April 2019.
- ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
- ↑ "Ezetimibe Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved 18 August 2025.
External links
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