Jump to content

Fexofenadine

From Wikipedia
fexofenadine
group of stereoisomers
Subclass ofpiperidine alkaloids, carboxylic acid Edit
Get useMedication Edit
Chemical formulaC₃₂H₃₉NO₄ Edit
Canonical SMILESCC(C)(C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O)C(=O)O Edit
Active ingredient inMucinex Non-Drowsy Allergy, Wal-Fex, Allegra Edit
Found insyd taxonStreptomyces platensis Edit
Physically dey interact plusHistamine receptor H1 Edit
Pregnancy categoryAustralian pregnancy category B2, US pregnancy category C Edit
LiverTox likelihood scoreLiverTox toxicity likelihood category E Edit
Subject has roleH1 antagonist, anti-allergic agents, non-sedating histamine H1 antagonist Edit

Fexofenadine, dem sell under de brand name Allegra among odas,[1] be an antihistamine medication dem use insyd de treatment of allergy symptoms such as allergic rhinitis den urticaria.[2]

Therapeutically, fexofenadine be a selective peripheral H1 blocker. E be classified as a second-generation antihistamine secof e be less able to pass de blood–brain barrier den cause sedation, dem compare to first-generation antihistamines.[3][4]

Na dem patent am insyd 1979 wey e cam into medical use insyd 1996.[5] Fexofenadine be a therapeutic alternative on de World Health Organization's List of Essential Medicines.[6] Na fexofenadine be manufactured insyd generic form since 2011.[7] In 2023, it was the 219th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[8][9]

References

[edit | edit source]
  1. ↑ "Fexofenadine - international brand names". Drugs.com. Retrieved 18 January 2017.
  2. ↑ Bachert C (May 2009). "A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis". Clinical Therapeutics. 31 (5): 921–944. doi:10.1016/j.clinthera.2009.05.017. PMID 19539095.
  3. ↑ Compalati E, Baena-Cagnani R, Penagos M, Badellino H, Braido F, Gómez RM, Canonica GW, Baena-Cagnani CE (2011). "Systematic review on the efficacy of fexofenadine in seasonal allergic rhinitis: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials". International Archives of Allergy and Immunology. 156 (1): 1–15. doi:10.1159/000321896. PMID 21969990.
  4. ↑ Dicpinigaitis PV, Gayle YE (November 2003). "Effect of the second-generation antihistamine, fexofenadine, on cough reflex sensitivity and pulmonary function". British Journal of Clinical Pharmacology. 56 (5): 501–504. doi:10.1046/j.1365-2125.2003.01902.x. PMC 1884387. PMID 14651723.
  5. ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 548. ISBN 9783527607495.
  6. ↑ World Health Organization (2025). The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines, 24th list. Geneva: World Health Organization. hdl:10665/382243.
  7. ↑ "Dr. Reddy's announces the launch of Over-the-Counter Fexofenadine HCl and Pseudoephedrine HCl extended-release tablets". Dr. Reddy's Laboratories Ltd. 30 August 2011. Archived from the original on 12 October 2016. Retrieved 27 May 2016.
  8. ↑ "The Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  9. ↑ "Fexofenadine Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved 20 August 2025.
[edit | edit source]
Dem retrieve am from "https://gpe.wikipedia.org/w/index.php?title=Fexofenadine&oldid=97667"