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Finasteride

From Wikipedia
finasteride
type of chemical entity
Subclass of(1S,9aR,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide Edit
Get useMedication Edit
Stereoisomer of(1S,3aS,3bR,5aR,9aR,9bR,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide Edit
Chemical formulaC₂₃H₃₆N₂O₂ Edit
Canonical SMILESCC12CCC3C(C1CCC2C(=O)NC(C)(C)C)CCC4C3(C=CC(=O)N4)C Edit
Isomeric SMILESC[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC(C)(C)C)CC[C@@H]4[C@@]3(C=CC(=O)N4)C Edit
Active ingredient inPropecia, Proscar Edit
World Health Organisation international non-proprietary namefinasteride Edit
Medical condition treatedProstate cancer, bald head, prostate disease, prostatic hypertrophy, Benign Prostatic Hyperplasia Edit
Physically dey interact plusSteroid 5 alpha-reductase 2 Edit
LiverTox likelihood scoreLiverTox toxicity likelihood category E Edit
Subject has role5-alpha-reductase inhibitors, urological agents Edit

Finasteride, dem sell under de brand names Proscar (5 mg) den Propecia (1 mg) among odas, be a medication dem use to treat pattern hair loss den benign prostatic hyperplasia (BPH).[1] E sanso fi be used to treat excessive hair growth insyd women.[2] E usually be taken orally buh der be topical formulations give patients plus hair loss, dem design to minimize systemic exposure by acting specifically on hair follicles.[3]

Finasteride be a 5α-reductase inhibitor den therefore an antiandrogen.[4] E dey work by decreasing de production of dihydrotestosterone (DHT) by about 70% insyd serum, 90% insyd prostate.[5]

Insyd addition to DHT, finasteride sanso dey inhibit de production of several anticonvulsant neurosteroids wey dey include allopregnanolone, androstanediol, den tetrahydrodeoxycorticosterone.[6]

Adverse effects from finasteride be rare insyd men plus already enlarged prostates;[7] however, sam men experience sexual dysfunction, depression, den breast enlargement.[8][9] Insyd sam men, sexual dysfunction fi persist after stopping de medication.[10][11] E sanso fi hide de early symptoms of certain forms of prostate cancer.[9]

Finasteride be patented insyd 1984 wey dem approve am for medical use insyd 1992.[12] E be available as a generic medication.[13] Insyd 2023, na e be de 91st most commonly prescribed medication insyd de United States, plus more dan 7 million prescriptions.[14][15]

References

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  1. ↑ "Finasteride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 25 August 2018. Retrieved 5 March 2019.
  2. ↑ Blume-Peytavi U, Whiting DA, Trüeb RM (26 June 2008). Hair Growth and Disorders. Springer Science & Business Media. p. 369. ISBN 978-3-540-46911-7. Archived from the original on 10 January 2023. Retrieved 10 December 2016.
  3. ↑ Piraccini BM, Blume-Peytavi U, Scarci F, Jansat JM, Falqués M, Otero R, Tamarit ML, Galván J, Tebbs V, Massana E (February 2022). "Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial". Journal of the European Academy of Dermatology and Venereology. 36 (2): 286–294. doi:10.1111/jdv.17738. PMC 9297965. PMID 34634163.
  4. ↑ Ferri FF (2014). Ferri's Clinical Advisor 2015 E-Book: 5 Books in 1. Elsevier Health Sciences. p. 580. ISBN 978-0-323-08430-7. Archived from the original on 10 January 2023. Retrieved 7 May 2020.
  5. ↑ Zito PM, Bistas KG, Patel P, Syed K (2026). "Finasteride". StatPearls. Treasure Island (FL): StatPearls Publishing. PMID 30020701. Retrieved 2026-07-24.
  6. ↑ Samba Reddy D, Ramanathan G (September 2012). "Finasteride inhibits the disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis". Epilepsy & Behavior. 25 (1): 92–97. doi:10.1016/j.yebeh.2012.05.024. PMC 3444667. PMID 22835430.
  7. ↑ Tacklind J, Fink HA, Macdonald R, Rutks I, Wilt TJ (October 2010). "Finasteride for benign prostatic hyperplasia". The Cochrane Database of Systematic Reviews. 2010 (10) CD006015. doi:10.1002/14651858.CD006015.pub3. PMC 8908761. PMID 20927745.
  8. ↑ Zakhem GA, Goldberg JE, Motosko CC, Cohen BE, Ho RS (July 2019). "Sexual dysfunction in men taking systemic dermatologic medication: A systematic review". Journal of the American Academy of Dermatology. 81 (1): 163–172. doi:10.1016/j.jaad.2019.03.043. PMID 30905792. S2CID 85497115.
  9. 1 2 Varothai S, Bergfeld WF (July 2014). "Androgenetic alopecia: an evidence-based treatment update". American Journal of Clinical Dermatology. 15 (3): 217–230. doi:10.1007/s40257-014-0077-5. PMID 24848508. S2CID 31245042.
  10. ↑ Zakhem GA, Goldberg JE, Motosko CC, Cohen BE, Ho RS (July 2019). "Sexual dysfunction in men taking systemic dermatologic medication: A systematic review". Journal of the American Academy of Dermatology. 81 (1): 163–172. doi:10.1016/j.jaad.2019.03.043. PMID 30905792. S2CID 85497115. In studies addressing reversibility, most of these patients have resolution of sexual adverse effects after discontinuation of finasteride, and many have improvement of adverse effects over time with continued finasteride use. However, some studies describe a subset of patients with persistent adverse effects after discontinuation... Level 1 evidence evaluating sexual dysfunction as a primary outcome was available for finasteride.
  11. ↑ Traish AM (January 2020). "Post-finasteride syndrome: a surmountable challenge for clinicians". Fertility and Sterility. 113 (1): 21–50. doi:10.1016/j.fertnstert.2019.11.030. PMID 32033719. S2CID 211064052.
  12. ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 483. ISBN 978-3-527-60749-5. Archived from the original on 10 January 2023. Retrieved 7 May 2020.
  13. ↑ Sataloff RT, Sclafani AP (30 November 2015). Sataloff's Comprehensive Textbook of Otolaryngology: Head & Neck Surgery: Facial Plastic and Reconstructive Surgery. JP Medical Ltd. pp. 400–. ISBN 978-93-5152-459-5. Archived from the original on 10 January 2023. Retrieved 4 December 2017.
  14. ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  15. ↑ "Finasteride Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 18 August 2025.
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