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Fluoxetine

From Wikipedia
fluoxetine
group of stereoisomers
Subclass ofchemical compound Edit
Part ofresponse to fluoxetine, cellular response to fluoxetine Edit
Get useMedication Edit
Stylized nameFLUoxetine, PROzac Edit
Discoverer or inventorDavid T. Wong Edit
Chemical formulaC₁₇H₁₈F₃NO Edit
Canonical SMILESCNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F Edit
Active ingredient inProzac, Sarafem, Magrilan, Deprex, Defluox Edit
World Health Organisation international non-proprietary namefluoxetine Edit
Found insyd taxonHordeum vulgare Edit
Physically dey interact plus5-hydroxytryptamine receptor 2B, Anoctamin 1, Potassium inwardly-rectifying channel, subfamily J, member 6, Solute carrier family 29 member 4, solute carrier family 6 member 4 Edit
Route of administrationoral administration Edit
Legal status (medicine)boxed warning Edit
Pregnancy categoryAustralian pregnancy category C, US pregnancy category C Edit
LiverTox likelihood scoreLiverTox toxicity likelihood category C Edit
Subject has roleselective serotonin reuptake inhibitor, cytochrome P-450 CYP2D6 inhibitors, second-generation antidepressive agents, essential medicine Edit

Fluoxetine, dem sell under de brand name Prozac, among odas, be an antidepressant medication of de selective serotonin reuptake inhibitor (SSRI) class[1] dem use for de treatment of major depressive disorder, anxiety, obsessive–compulsive disorder (OCD), panic disorder, premenstrual dysphoric disorder, den bulimia nervosa.[1] Dem sanso approve am for treatment of major depressive disorder insyd adolescents den kiddies 8 years of age den over.[2] Na dem sanso use am to treat premature ejaculation.[1] Fluoxetine be taken by mouth.[1]

Common side effects dey include loss of appetite, nausea, diarrhea, headache, trouble sleeping, dry mouth, den sexual dysfunction. Serious side effects dey include serotonin syndrome, mania, seizures, an increased risk of suicidal behavior, den an increased risk of bleeding.[1] Antidepressant discontinuation syndrome be less likely to occur plus fluoxetine dan plus oda antidepressants. Fluoxetine wey dem take during pregnancy be associated plus a significant increase insyd congenital heart defects insyd newborns.[3][4] Na dem suggest say fluoxetine therapy fi be continued during breastfeeding if na dem use am during pregnancy anaa if na oda antidepressants be ineffective.[5]

Na Eli Lilly and Company invent fluoxetine insyd 1972 wey e enter medical use insyd 1986.[6] E dey on de World Health Organization's List of Essential Medicines[7] wey e be available as a generic medication.[1] Insyd 2023, na e be de eighteenth most commonly prescribed medication insyd de United States den de fourth most common antidepressant, plus more dan 27 million prescriptions.[8][9]

Eli Lilly sanso dey market fluoxetine insyd a fixed-dose combination plus olanzapine as olanzapine/fluoxetine (Symbyax), wich na e be approved by de US Food and Drug Administration (FDA) for de treatment of depressive episodes of bipolar I disorder insyd 2003 den for treatment-resistant depression insyd 2009.[10][11]

References

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  1. 1 2 3 4 5 6 "Fluoxetine Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 8 December 2015. Retrieved 2 December 2015.
  2. ↑ "Depressive Disorders in Children and Adolescents – Pediatrics". Merck Manuals Professional Edition. Retrieved 25 December 2020.
  3. ↑ Gao SY, Wu QJ, Sun C, Zhang TN, Shen ZQ, Liu CX, Gong TT, Xu X, Ji C, Huang DH, Chang Q, Zhao YH (November 2018). "Selective serotonin reuptake inhibitor use during early pregnancy and congenital malformations: a systematic review and meta-analysis of cohort studies of more than 9 million births". BMC Medicine. 16 (1) 205. doi:10.1186/s12916-018-1193-5. PMC 6231277. PMID 30415641.
  4. ↑ De Vries C, Gadzhanova S, Sykes MJ, Ward M, Roughead E (March 2021). "A Systematic Review and Meta-Analysis Considering the Risk for Congenital Heart Defects of Antidepressant Classes and Individual Antidepressants". Drug Safety. 44 (3): 291–312. doi:10.1007/s40264-020-01027-x. PMID 33354752. S2CID 229357583.
  5. ↑ "Fluoxetine Pregnancy and Breastfeeding Warnings". Archived from the original on 31 August 2017. Retrieved 2 December 2015.
  6. ↑ Myers RL (2007). The 100 most important chemical compounds: a reference guide (1st ed.). Westport, CN: Greenwood Press. p. 128. ISBN 978-0-313-33758-1.
  7. ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  8. ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  9. ↑ Myers RL (2007). The 100 most important chemical compounds: a reference guide (1st ed.). Westport, CN: Greenwood Press. p. 128. ISBN 978-0-313-33758-1.
  10. ↑ "Symbyax- olanzapine and fluoxetine hydrochloride capsule". DailyMed. 21 April 2020. Retrieved 30 September 2020.
  11. ↑ Grohol, J. "FDA Approves Symbyax for Treatment Resistant Depression". Psych Central Blog. Archived from the original on 26 December 2017. Retrieved 17 July 2010.
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