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Frontotemporal dementia

From Wikipedia
frontotemporal dementia
rare disease, class of disease
Has causeunknown Edit
Health specialtyNeurology, psychiatry, and neuropsychiatry Edit
Medical examinationmedical history, neurological diagnostic techniques, magnetic resonance imaging, autopsy Edit
Possible treatmentselective serotonin reuptake inhibitor, antipsychotics Edit
Genetic associationCHMP2B Edit
NCI Thesaurus IDC84719 Edit

Frontotemporal dementia (FTD), dem sanso call frontotemporal degeneration disease[1] anaa frontotemporal neurocognitive disorder,[2] dey encompass several types of dementia wey dey involve de progressive degeneration of de brain ein frontal den temporal lobes.[3] Men den women appear to be equally affected.[1] FTD generally dey present as a behavioral anaa language disorder plus gradual onset.[4] Signs den symptoms tend to appear insyd mid adulthood, typically between de ages of 45 den 65, although e fi affect people younger anaa older dan dis.[1] As of 2017 der be no cure anaa approved symptomatic treatment give FTD, although na dem prescribe sam off-label drugs den behavioral methods.[1]

Na dem first describe features of FTD by Arnold Pick between 1892 den 1906.[5] Na dem coin de name Pick's disease insyd 1922,[6] buh na dem reserve am for de behavioral variant of FTD, insyd wich characteristic Pick bodies den Pick cells be present.[7][8] Na dem first describe dese by Alois Alzheimer insyd 1911.[6] Common signs den symptoms dey include significant changes insyd social den personal behavior, disinhibition, apathy, blunting den dysregulation of emotions, den deficits insyd both expressive den receptive language.[9]

Each FTD subtype relatively be rare.[10] FTDs mostly be early onset syndromes dem link to frontotemporal lobar degeneration (FTLD),[11] wich be characterized by progressive neuronal loss predominantly wey dey involve de frontal anaa temporal lobes, den a typical loss of more dan 70% of spindle neurons, while oda neuron types remain intact.[12] De three main subtypes anaa variant syndromes be a behavioral variant (bvFTD) dem previously know as Pick's disease, den two variants of primary progressive aphasia (PPA): semantic (svPPA) den nonfluent (nfvPPA). Two rare distinct subtypes of FTD be neuronal intermediate filament inclusion disease (NIFID) den basophilic inclusion body disease (BIBD). Oda related disorders dey include corticobasal syndrome (CBS anaa CBD), den FTD plus amyotrophic lateral sclerosis (ALS).

Notable cases

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People wey na dem be diagnosed as having FTD (dem often refer to as Pick's disease in cases of de behavioral variant) dey include:

  • John Berry (1963–2016), American hardcore punk musician den founding member of de Beastie Boys[13]
  • Clancy Blair (1960–2024), American developmental psychologist den professor
  • Don Cardwell (1935–2008), Major League Baseball pitcher[14]
  • Charmian Carr (1942–2016), wey play Liesl, from de Sound of Music, dem born Charmian Anne Farnon
  • Jerry Corbetta (1947–2016), frontman, organist den keyboardist of American psychedelic rock band Sugarloaf[15]
  • Ted Darling (1935–1996), Buffalo Sabres television announcer
  • Robert W. Floyd (1936–2001), computer scientist[16]
  • Lee Holloway (born 1982), computer scientist, co-founder of Cloudflare[17]
  • Colleen Howe (1933–2009), sports agent den ice hockey team manager, dem know as "Mrs. Hockey"[18]
  • Kazi Nazrul Islam (1899–1976) national poet of Bangladesh[19]
  • Terry Jones (1942–2020), Welsh comedian (Monty Python) den director
  • Ralph Klein (1942–2013), former premier of Alberta, Canada
  • Kevin Moore (1958–2013), English footballer[20]
  • Ernie Moss (1949–2021), English footballer[21]
  • Nic Potter (1951–2013), British bassist for Van der Graaf Generator[22]
  • Christina Ramberg (1946–1995), American painter wey associate plus de Chicago Imagists[23]
  • David Rumelhart (1942–2011), American cognitive psychologist
  • Sir Nicholas Wall (1945–2017), English judge[24]
  • Bruce Willis (born 1955), American actor[25]
  • Mark Wirtz (1943–2020), pop musician, composer den producer[26]
  • Curtis Hanson (1945–2016), American film director, screenwriter, den producer[27]

References

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  1. 1 2 3 4 Olney NT, Spina S, Miller BL (May 2017). "Frontotemporal dementia". Neurologic Clinics. 35 (2): 339–374. doi:10.1016/j.ncl.2017.01.008. PMC 5472209. PMID 28410663.
  2. ↑ Diagnostic and statistical manual of mental disorders: DSM-5 (5th ed.). Arlington, Virginia: American Psychiatric Association. 2013. pp. 614–618. ISBN 978-0-89042-554-1.
  3. ↑ "ICD-11 – Mortality and Morbidity Statistics". icd.who.int. World Health Organization. Archived from the original on 2018-08-01.
  4. ↑ Sivasathiaseelan H, Marshall CR, Agustus JL, et al. (April 2019). "Frontotemporal Dementia: A Clinical Review". Seminars in Neurology. 39 (2): 251–263. doi:10.1055/s-0039-1683379. PMID 30925617. S2CID 88481297.
  5. ↑ Mikol J (2018). "History of Pick's disease". Revue Neurologique (in English). 174 (10): 740–741. doi:10.1016/j.neurol.2018.09.009. ISSN 0035-3787. S2CID 81923630.
  6. 1 2 Pearce JM (February 2003). "Pick's disease". Journal of Neurology, Neurosurgery, and Psychiatry. 74 (2): 169. doi:10.1136/jnnp.74.2.169. PMC 1738259. PMID 12531941.
  7. ↑ Ropper AH, Samuels MA, Klein JP (2019). Adams and Victor's Principles of Neurology (11th ed.). McGraw Hill. p. 1096. ISBN 978-0-07-184262-4.
  8. ↑ Cardarelli R, Kertesz A, Knebl JA (December 2010). "Frontotemporal dementia: a review for primary care physicians". American Family Physician. 82 (11): 1372–1377. PMID 21121521.
  9. ↑ "Frontotemporal dementia". hopkinsmedicine.org. Johns Hopkins Medicine. 2024. Retrieved 23 March 2024.
  10. ↑ Borroni B, Graff C, Hardiman O, et al. (March 2022). "FRONTotemporal dementia Incidence European Research Study-FRONTIERS: Rationale and design". Alzheimer's & Dementia. 18 (3): 498–506. doi:10.1002/alz.12414. PMC 9291221. PMID 34338439.
  11. ↑ Hofmann JW, Seeley WW, Huang EJ (January 2019). "RNA Binding Proteins and the Pathogenesis of Frontotemporal Lobar Degeneration". Annual Review of Pathology. 14: 469–495. doi:10.1146/annurev-pathmechdis-012418-012955. PMC 6731550. PMID 30355151.
  12. ↑ Chen I (June 2009). "Brain Cells for Socializing". Smithsonian Magazine. Smithsonian. Retrieved 30 October 2015.
  13. ↑ Oyebode J (31 May 2016). "Beastie Boy John Berry Died of Frontal Lobe Dementia – But What Is It?". Elsevier. Retrieved 10 May 2022.
  14. ↑ Goldstein R (16 January 2008). "Don Cardwell, 72, Pitcher for 1969 Mets, Is Dead". The New York Times.
  15. ↑ Oyebode J (31 May 2016). "Beastie Boy John Berry Died of Frontal Lobe Dementia – But What Is It?". Elsevier. Retrieved 10 May 2022.
  16. ↑ Knuth DE (December 2003). "Robert W Floyd, In Memoriam". ACM SIGACT News. 34 (4): 3–13. doi:10.1145/954092.954488. S2CID 35605565. Archived from the original on 2017-04-22. Retrieved 2020-12-12.
  17. ↑ Upson S (15 April 2020). "The Devastating Decline of a Brilliant Young Coder". Wired.
  18. ↑ Sipple G (March 6, 2009). "Fans mourn loss of "Mrs. Hockey," Colleen Howe". The Detroit Free Press. Archived from the original on October 4, 2015. Retrieved October 3, 2015.
  19. ↑ Knuth DE (December 2003). "Robert W Floyd, In Memoriam". ACM SIGACT News. 34 (4): 3–13. doi:10.1145/954092.954488. S2CID 35605565. Archived from the original on 2017-04-22. Retrieved 2020-12-12.
  20. ↑ Sportsteam. "Grimsby Town legend Kevin Moore passes away". Archived from the original on 2013-05-03. Retrieved 2013-04-29.
  21. ↑ "Support for Valiants hero Ernie Moss after he is diagnosed with Pick's Disease". The Sentinel. 11 October 2014. Archived from the original on 2 November 2014. Retrieved 11 October 2014.
  22. ↑ Potter S (22 January 2013). "Nic Potter obituary | Music | guardian.co.uk". London: Guardian. Retrieved 22 January 2013.
  23. ↑ Cook G (27 February 2014). "The Sexy, Proto-Feminist Art Of Christina Ramberg's Tragically Short Life". www.wbur.org.
  24. ↑ Rayner G (23 February 2017). "Sir Nicholas Wall, once Britain's top family law judge, commits suicide after dementia diagnosis". The Daily Telegraph.
  25. ↑ Moreau J (2023-02-16). "Bruce Willis Diagnosed With Dementia After Retiring Due to Aphasia". Variety. Retrieved 2023-02-16.
  26. ↑ "Mark Wirtz, musician and producer who had a global hit with Excerpt from a Teenage Opera – obituary". The Daily Telegraph. 13 August 2020. Archived from the original on 27 August 2020.
  27. ↑ Kenneally, Tim (September 21, 2016). "Curtis Hanson Suffered From Rare Illness, His Partner Reveals".

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