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Furosemide

From Wikipedia
furosemide
type of chemical entity
Subclass offuran, benzenesulfonamides, aromatic carboxylic acid, aniline, monochlorobenzene Edit
Get useMedication Edit
Chemical formulaC₁₂H₁₁ClN₂O₅S Edit
Canonical SMILESC1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl Edit
Active ingredient inLasix Edit
Physically dey interact plusSolute carrier family 12 member 2, G protein-coupled receptor 35, Solute carrier family 12 member 1 Edit
Legal status (medicine)boxed warning Edit
Pregnancy categoryAustralian pregnancy category C, US pregnancy category C Edit
ManufacturerPfizer Edit
Subject has rolesodium potassium chloride symporter inhibitors, diuretic, essential medicine Edit
MCN code2935.90.21 Edit

Furosemide, dem sell under de brand name Lasix among odas, be a loop diuretic medication dem use to treat edema secof heart failure, liver scarring, anaa kidney disease.[1] Furosemide sanso fi be used for de treatment of high blood pressure.[1] Dem fi take am intravenously anaa orally.[1] When dem give intravenously, furosemide typically dey take effect within five minutes; wen dem take am orally, e typically dey metabolize within an hour.[1]

Common side effects dey include orthostatic hypotension (decrease insyd blood pressure while standing, den associated lightheadedness), tinnitus (ringing insyd de ears), den photosensitivity (sensitivity to light).[1] Potentially serious side effects dey include electrolyte abnormalities, low blood pressure, den hearing loss.[1] Dem dey recommend say serum electrolytes (especially potassium), serum CO2, creatinine, BUN levels, den liver den kidney functioning be monitored insyd patients wey dey take furosemide. E sanso e recommended to be alert for de occurrence of any potential blood dyscrasias.[1]

Furosemide dey work by decreasing de reabsorption of sodium by de kidneys.[1] Common side effects of furosemide injection dey include hypokalemia (low potassium level), hypotension (low blood pressure), den dizziness.[2]

Na dem patent furosemide insyd 1959 wey dem approve am for medical use insyd 1964.[3] E dey on de World Health Organization's List of Essential Medicines.[4] Insyd de United States, e be available as a generic medication.[1] Insyd 2023, na e be de 29th most commonly prescribed medication insyd de United States, plus more dan 19 million prescriptions.[5][6] Insyd 2020/21 na e be de twentieth most prescribed medication insyd England.[7] E dey on de World Anti-Doping Agency ein banned drug list secof concerns say e fi mask oda drugs.[8] E sanso be used insyd race horses for de treatment den prevention of exercise-induced pulmonary hemorrhage.[9][10]

References

[edit | edit source]
  1. 1 2 3 4 5 6 7 8 9 "Furosemide". The American Society of Health-System Pharmacists. Archived from the original on 19 November 2015. Retrieved 23 October 2015.
  2. ↑ "Coronavirus (COVID-19) Update: December 22, 2020". U.S. Food and Drug Administration (Press release). 22 December 2020. Retrieved 22 December 2020.
  3. ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 458. ISBN 978-3-527-60749-5.
  4. ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  5. ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  6. ↑ "Furosemide Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 13 August 2025.
  7. ↑ "PCA England". NHS Business Services Authority. Retrieved 8 August 2022.
  8. ↑ "World Anti-doping Code International Standard Prohibited List 2022" (PDF). 2022. p. 12. Archived (PDF) from the original on 10 July 2022. Retrieved 27 July 2022.
  9. ↑ Sullivan S, Hinchcliff K (April 2015). "Update on exercise-induced pulmonary hemorrhage". The Veterinary Clinics of North America. Equine Practice. 31 (1): 187–198. doi:10.1016/j.cveq.2014.11.011. PMID 25770069.
  10. ↑ Hinchcliff KW, Couetil LL, Knight PK, Morley PS, Robinson NE, Sweeney CR, van Erck E (2015). "Exercise induced pulmonary hemorrhage in horses: American College of Veterinary Internal Medicine consensus statement". Journal of Veterinary Internal Medicine. 29 (3): 743–758. doi:10.1111/jvim.12593. PMC 4895427. PMID 25996660.

Read further

[edit | edit source]
  • Aventis Pharma (1998). Lasix Approved Product Information. Lane Cove: Aventis Pharma Pty Ltd.
  • Forney B (2007). Understanding Equine Medications, Revised Edition (Horse Health Care Library). Eclipse Press. ISBN 978-1-58150-151-3.
[edit | edit source]
Dem retrieve am from "https://gpe.wikipedia.org/w/index.php?title=Furosemide&oldid=98365"