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Gynecomastia

From Wikipedia
gynecomastia
class of disease
Subclass ofsex differentiation disease Edit
Has causechronic renal insufficiency, obesity, liver cirrhosis, malnutrition, Medication Edit
Health specialtyendocrinology, plastic surgery Edit
Drug or therapy used for treatmentaromatase inhibitors, selective estrogen-receptor modulators Edit
WordLift URLhttp://data.medicalrecords.com/medicalrecords/healthwise/gynecomastia Edit
NCI Thesaurus IDC3073 Edit

Gynecomastia (dem sanso spell am gynaecomastia) be de non-cancerous enlargement of one anaa both breasts insyd men secof de growth of breast tissue as a result of a hormone imbalance between estrogens den androgens.[1][2] Physically speaking, gynecomastia be completely benign, buh e dey associate plus significant psychological distress, social stigma, den dysphoria.[3]

Gynecomastia fi be normal insyd newborn male babies secof exposure to estrogen from de mommie, insyd adolescent boys wey dey go thru puberty, in older men over de age of 50, den insyd obese men.[1] Chaw occurrences of gynecomastia no dey require diagnostic tests.[1][2] Gynecomastia fi be caused by abnormal hormone changes, any condition wey dey lead to an increase insyd de ratio of estrogens/androgens such as liver disease, kidney failure, thyroid disease den sam non-breast tumors. Alcohol den sam drugs sanso fi cause breast enlargement.[1][4] Oda causes fi include Klinefelter syndrome, metabolic dysfunction, anaa a natural decline insyd testosterone production.[1][3][5] Dis fi occur even if de levels of estrogens den androgens both be appropriate, buh dem alter de ratio.[4]

Gynecomastia be de most common benign disorder of de male breast tissue wey dey affect 35% of men, wey e be most prevalent between de ages of 50 den 69.[2][6] E be normal for up to 70% of adolescent boys make dem develop gynecomastia to sam degree.[3] Of dese, 75% resolve within two years of onset widout treatment.[7] If de condition no dey resolve within 2 years, anaa if e dey cause embarrassment, pain anaa tenderness, treatment be warranted.[8][9] Medical treatment of gynecomastia wey na e persist beyond two years be often ineffective. Gynecomastia be different from "pseudogynecomastia",[2][3] which be commonly present insyd men plus obesity.[10][11]

Na dem find medications such as aromatase inhibitors e be effective[12] den even insyd rare cases of gynecomastia from disorders such as aromatase excess syndrome anaa Peutz–Jeghers syndrome,[13] buh surgical removal of de excess tissue fi be needed to correct de condition.[14] Insyd 2019, na 24,123 male patients undergo de procedure insyd de United States, wey dey account for a 19% increase since 2000.[15]

References

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  1. 1.0 1.1 1.2 1.3 1.4 "Breast enlargement in males: MedlinePlus Medical Encyclopedia". medlineplus.gov (in English). 2018. Retrieved 25 November 2020. Updated by Brent Wisse (10 November 2018)
  2. 2.0 2.1 2.2 2.3 Thiruchelvam, Paul; Walker, Jonathan Neil; Rose, Katy; Lewis, Jacqueline; Al-Mufti, Ragheed (22 September 2016). "Gynaecomastia". BMJ. 354 i4833. doi:10.1136/bmj.i4833. PMID 27659195. S2CID 220098795.
  3. 3.0 3.1 3.2 3.3 Niewoehner, CB; Schorer, AE (March 2008). "Gynaecomastia and breast cancer in men". British Medical Journal. 336 (7646): 709–713. doi:10.1136/bmj.39511.493391.BE. PMC 2276281. PMID 18369226.
  4. 4.0 4.1 Narula, Harmeet S.; Carlson, Harold E. (November 2014). "Gynaecomastia—pathophysiology, diagnosis and treatment". Nature Reviews Endocrinology. 10 (11): 684–698. doi:10.1038/nrendo.2014.139. PMID 25112235. S2CID 40159424.
  5. Johnson RE, Murad MH (November 2009). "Gynecomastia: pathophysiology, evaluation, and management". Mayo Clinic Proceedings. 84 (11): 1010–1015. doi:10.4065/84.11.1010. PMC 2770912. PMID 19880691.
  6. Chau, A; Jafarian, N; Rosa, M (February 2016). "Male Breast: Clinical and Imaging Evaluations of Benign and Malignant Entities with Histologic Correlation". The American Journal of Medicine (Review). 129 (8): 776–91. doi:10.1016/j.amjmed.2016.01.009. PMID 26844632.
  7. Shulman, D. I.; Francis, G. L.; Palmert, M. R.; Eugster, E. A.; Lawson Wilkins Pediatric Endocrine Society Drug and Therapeutics, Committee. (1 April 2008). "Use of Aromatase Inhibitors in Children and Adolescents With Disorders of Growth and Adolescent Development". Pediatrics. 121 (4): e975 – e983. doi:10.1542/peds.2007-2081. PMID 18381525. S2CID 39852740.
  8. "Gynecomastia: Surgery, treatment, causes, and symptoms". www.medicalnewstoday.com (in English). 2018-01-11. Retrieved 2021-04-16.
  9. Dickson, Gretchen (2012-04-01). "Gynecomastia". American Family Physician. 85 (7): 716–722. ISSN 0002-838X. PMID 22534349.
  10. Z. Hochberg (1 January 2007). Practical Algorithms in Pediatric Endocrinology. Karger Medical and Scientific Publishers. pp. 21–. ISBN 978-3-8055-8220-9.
  11. Seth Thaller; Mimis Cohen (28 February 2013). Cosmetic Surgery After Massive Weight Loss. JP Medical Ltd. pp. 133–. ISBN 978-1-907816-28-4.
  12. de Ronde, Willem; de Jong, Frank H. (2011-06-21). "Aromatase inhibitors in men: effects and therapeutic options". Reproductive Biology and Endocrinology. 9 (1): 93. doi:10.1186/1477-7827-9-93. ISSN 1477-7827. PMC 3143915. PMID 21693046 – via DOI.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  13. Wit, Jan M.; Hero, Matti; Nunez, Susan B. (March 2012). "Aromatase inhibitors in pediatrics". Nature Reviews Endocrinology. 8 (3): 135–147. doi:10.1038/nrendo.2011.161. PMID 22024975. S2CID 21710403.
  14. Deepinder F, Braunstein GD (2012). "Drug-induced gynecomastia: an evidence-based review". Expert Opinion on Drug Safety. 11 (5): 779–795. doi:10.1517/14740338.2012.712109. PMID 22862307. S2CID 22938364.
  15. "Plastic Surgery Statistics Report" (PDF). American Society of Plastic Surgeons. 2019. Archived from the original (PDF) on 19 February 2021.
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