Hydroxyzine
| Subclass of | monochlorobenzene, piperazines, ethers, primary alcohol, Medication  |
|---|---|
| Stylized name | hydrOXYzine |
| Chemical formula | C₂₁H₂₇ClN₂O₂ |
| Canonical SMILES | C1CN(CCN1CCOCCO)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl |
| Active ingredient in | Atarax, Vistaril |
| World Health Organisation international non-proprietary name | hydroxyzine |
| Medical condition treated | anxiety disorder, vomiting, anxiety |
| Physically dey interact plus | Histamine receptor H1 |
| Pregnancy category | Australian pregnancy category A, US pregnancy category C |
| LiverTox likelihood score | LiverTox toxicity likelihood category E |
| Subject has role | antipruritic, histamine antagonist, H1 antagonist |
Hydroxyzine, dem sell under de brand names Atarax den Vistaril among odas, be an antihistamine medication.[1] Dem dey use am insyd de treatment of itchiness, anxiety, insomnia, den nausea (wey dey include dat secof motion sickness).[1] Dem dey use am either by mouth anaa injection into a muscle.[1]
Hydroxyzine dey work by blocking de effects of histamine.[2] E be a first-generation antihistamine insyd de piperazine family of chemicals.[1][3] Common side effects dey include sleepiness, headache, den dry mouth.[1][2] Serious side effects fi include QT prolongation.[2] E be unclear if ein use during pregnancy anaa breastfeeding be safe.[1]
Na Union Chimique Belge first make am insyd 1956 wey na dem approve am for sale by Pfizer insyd de United States later dat year.[1][4] Insyd 2023, na e be de 39th most commonly prescribed medication insyd de United States, plus more dan 15 million prescriptions.[5][6]
References
[edit | edit source]- 1 2 3 4 5 6 7 "Hydroxyzine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 21 November 2018.
- 1 2 3 British national formulary: BNF 74 (74 ed.). British Medical Association. 2017. p. X. ISBN 978-0-85711-298-9.
- ↑ "Hydroxyzine". United States National Library of Medicine (NLM). Retrieved 4 March 2020.
- ↑ Shorter E (2009). Before Prozac: the troubled history of mood disorders in psychiatry. Oxford [Oxfordshire]: Oxford University Press. ISBN 978-0-19-536874-1.
- ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
- ↑ "Hydroxyzine Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved 18 August 2025.
External links
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