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Ibuprofen

From Wikipedia
ibuprofen
group of stereoisomers
Subclass ofaromatic compound, carboxylic acid Edit
Get useessential medicine, Medication Edit
Discoverer or inventorStewart Adams Edit
Chemical formulaC₁₃H₁₈O₂ Edit
Canonical SMILESCC(C)CC1=CC=C(C=C1)C(C)C(=O)O Edit
World Health Organisation international non-proprietary nameibuprofen, ibuprofenum Edit
Found insyd taxonArtemisia argyi, Plantago major, clove Edit
Legal status (medicine)General sales list (UK), boxed warning Edit
Pregnancy categoryAustralian pregnancy category C, US pregnancy category C Edit
LiverTox likelihood scoreLiverTox toxicity likelihood category A Edit
Described at URLhttps://pubchem.ncbi.nlm.nih.gov/compound/Ibuprofen#:~:text=Ibuprofen%20is%20a%20monocarboxylic%20acid,2%2Dmethylpropyl)phenyl%20group.&text=It%20derives%20from%20a%20propionic,of%20an%20ibuprofen(1%2D)., https://getpocket.com/explore/item/the-inventor-of-ibuprofen-tested-the-drug-on-his-own-hangover, https://www.stylist.co.uk/fitness-health/wellbeing/ibuprofen-paracetamol-gp-pharmacist/999946 Edit
Subject has rolecyclooxygenase inhibitors, non-opioid analgesic, non-steroidal anti-inflammatory drug Edit
MCN code2916.39.20 Edit

Ibuprofen be a nonsteroidal anti-inflammatory drug (NSAID) wey dem dey use to relieve pain, fever, den inflammation.[1] Dis dey include painful menstrual periods, migraines, den rheumatoid arthritis.[1] Dem fi take am orally (by mouth) anaa intravenously.[1] E typically dey begin dey work within an hour.[1]

Common side effects dey include heartburn, nausea, indigestion, den abdominal pain.[1] Potential side effects dey include gastrointestinal bleeding.[2] Na dem associate ein long-term use plus kidney failure, den rarely liver failure, wey e fi exacerbate de condition of people plus heart failure.[1] At low doses, e no dey appear to increase de risk of myocardial infarction (heart attack); however, at higher doses e fi be.[2] Ibuprofen sanso fi worsen asthma.[2] While ein safety in early pregnancy be unclear,[1] e dey appear to be harmful insyd later pregnancy, so dem no dey recommend during dat period.[3] E dey work by inhibiting de production of prostaglandins by e dey decrease de activity of de enzyme cyclooxygenase (COX).[1] Ibuprofen be a weaker anti-inflammatory agent dan oda NSAIDs.[2]

Na dem discover ibuprofen insyd 1961 by Stewart Adams den John Nicholson[4] while na he dey work at Boots the Chemists wey na dem initially sell as Brufen.[5] E be available under a number of brand names wey dey include Advil, Brufen, Motrin, den Nurofen.[1][6] Na dem first sell ibuprofen insyd 1969 insyd de United Kingdom den insyd 1974 insyd de United States.[1][5] E be on de World Health Organization's List of Essential Medicines.[7] E be available as a generic medication.[1] Insyd 2023, na e be de 32nd most commonly prescribed medication insyd de United States, plus more dan 17 million prescriptions.[8][9]

References

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  1. 1 2 3 4 5 6 7 8 9 10 11 "Ibuprofen". The American Society of Health-System Pharmacists. Archived from the original on 9 September 2017. Retrieved 12 October 2016.
  2. 1 2 3 4 British National Formulary, March 2014–September 2014 (2014 ed.). London: British Medical Association. 2014. pp. 686–688. ISBN 978-0-85711-086-2.
  3. ↑ "Ibuprofen Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on 9 September 2017. Retrieved 22 May 2016.
  4. ↑ Kindy D. "The Inventor of Ibuprofen Tested the Drug on His Own Hangover". Smithsonian Magazine. Archived from the original on 9 July 2021. Retrieved 3 July 2021. Stewart Adams and his associate John Nicholson invented a pharmaceutical drug known as 2-(4-isobutylphenyl) propionic acid.
  5. 1 2 Halford GM, Lordkipanidzé M, Watson SP (2012). "50th anniversary of the discovery of ibuprofen: an interview with Dr Stewart Adams". Platelets. 23 (6): 415–422. doi:10.3109/09537104.2011.632032. PMID 22098129. S2CID 26344532.
  6. ↑ "Chemistry in your cupboard: Nurofen". RSC Education. Archived from the original on 5 June 2014.
  7. ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  8. ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  9. ↑ "Ibuprofen Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 13 August 2025.
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