IgA nephropathy

designated intractable/rare disease, class of disease
Subclass of	glomerulonephritis, disease
Health specialty	nephrology, rheumatology
Drug or therapy used for treatment	mycophenolate mofetil
Genetic association	ACOXL
External data available at URL	http://www.nanbyou.or.jp/entry/41
ICD-9-CM	583.9
NCI Thesaurus ID	C34643, C35280

IgA nephropathy (IgAN), dem sanso know as Berger's disease (den variations), anaa synpharyngitic glomerulonephritis, be a disease of de kidney (anaa nephropathy) den de immune system; specifically e be a form of glomerulonephritis anaa an inflammation of de glomeruli of de kidney. Aggressive Berger's disease (a rarer form of de disease) fi attack oda major organs, such as de liver, skin den heart.

IgA nephropathy be de most common glomerulonephritis worldwide; de global incidence be 2.5/100,000 per year amongst adults.^[1] Aggressive Berger's disease dey on de NORD list of rare diseases.^[2] Primary IgA nephropathy be characterized by deposition of de IgA antibody insyd de glomerulus. Der be oda diseases wey associate plus glomerular IgA deposits, de most common be IgA vasculitis (dem formerly know as Henoch–Schönlein purpura [HSP]), wich na chaw consider am to be a systemic form of IgA nephropathy.^[3] IgA vasculitis dey present plus a characteristic purpuric skin rash, arthritis, den abdominal pain, wey dey occur more commonly insyd kiddies. HSP be associated plus a more benign prognosis dan IgA nephropathy. Insyd non-aggressive IgA nephropathy, der be traditionally a slow progression to chronic kidney failure insyd 25–30% of cases during 20 years.

References

↑ Kiryluk, Krzysztof; Li, Yifu; Sanna-Cherchi, Simone; Rohanizadegan, Mersedeh; Suzuki, Hitoshi; et al. (21 June 2012). "Geographic Differences in Genetic Susceptibility to IgA Nephropathy: GWAS Replication Study and Geospatial Risk Analysis". PLOS Genetics. 8 (6) e1002765. doi:10.1371/journal.pgen.1002765. PMC 3380840. PMID 22737082.
↑ D'Amico, G (1987). "The commonest glomerulonephritis in the world: IgA nephropathy". Q J Med. 64 (245): 709–27. PMID 3329736.
↑ C, Davin J (2001). "What is the difference between IgA nephropathy and Henoch-Schönlein purpura nephritis?". Kidney International. 59 (3): 823–34. doi:10.1046/j.1523-1755.2001.059003823.x. PMID 11231337.

External links

IGA Nephropathy on National Institute of Diabetes and Digestive and Kidney Diseases

[1] Kiryluk, Krzysztof; Li, Yifu; Sanna-Cherchi, Simone; Rohanizadegan, Mersedeh; Suzuki, Hitoshi; et al. (21 June 2012). "Geographic Differences in Genetic Susceptibility to IgA Nephropathy: GWAS Replication Study and Geospatial Risk Analysis". PLOS Genetics. 8 (6) e1002765. doi:10.1371/journal.pgen.1002765. PMC 3380840. PMID 22737082.

[2] D'Amico, G (1987). "The commonest glomerulonephritis in the world: IgA nephropathy". Q J Med. 64 (245): 709–27. PMID 3329736.

[3] C, Davin J (2001). "What is the difference between IgA nephropathy and Henoch-Schönlein purpura nephritis?". Kidney International. 59 (3): 823–34. doi:10.1046/j.1523-1755.2001.059003823.x. PMID 11231337.

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