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Ivermectin

From Wikipedia
ivermectin
mixture, Medication, essential medicine
Chemical formula Edit
Canonical SMILES Edit
Active ingredient inSklice, Stromectol, Soolantra Edit
World Health Organisation international non-proprietary nameivermectin Edit
Pregnancy categoryAustralian pregnancy category B3, US pregnancy category C Edit
LiverTox likelihood scoreLiverTox toxicity likelihood category D Edit
Described at URLhttps://www.theatlantic.com/science/archive/2021/10/ivermectin-research-problems/620473/?utm_source=pocket-newtab-global-en-GB Edit
Subject has roleinsecticide, antiparasitic Edit
NCI Thesaurus IDC61796 Edit

Ivermectin be an antiparasitic medication.[1] After ein discovery insyd 1975,[2] na ein first uses be insyd veterinary medicine to prevent den treat heartworm den acariasis.[3] Na dem approve am for human use insyd 1987,[4] dem dey use am to treat infestations wey dey include head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis den lymphatic filariasis.[3][5][6][7] E dey work thru chaw mechanisms to kill de targeted parasites,[5] wey dem fi take am by mouth, anaa applied to de skin for external infestations.[5][8] E dey belong to de avermectin family of medications.[5]

Na dem award William Campbell den Satoshi Ōmura de 2015 Nobel Prize insyd Physiology anaa Medicine for ein discovery den applications.[9] E dey on de World Health Organization's List of Essential Medicines.[10] wey e be approved by de US Food and Drug Administration (FDA) as an antiparasitic agent.[11] Insyd 2023, na e be de 295th most commonly prescribed medication insyd de United States, plus more dan 400,000 prescriptions.[12][13] E be available as a generic medicine.[14][15] Ivermectin be available insyd a fixed-dose combination plus albendazole.[16]

Na dem widely spread misinformation wey dey claim say ivermectin be beneficial for treating den preventing COVID-19.[17][18] Such claims no be backed by credible scientific evidence.[19][20][21] Multiple major health organizations, wey dey include de US Food and Drug Administration,[22] de US Centers for Disease Control and Prevention,[23] de European Medicines Agency,[20] den de World Health Organization advise against de use of ivermectin for de treatment of COVID-19.[20][24]

References

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  1. ↑ Laing R, Gillan V, Devaney E (June 2017). "Ivermectin – Old Drug, New Tricks?". Trends in Parasitology. 33 (6): 463–472. doi:10.1016/j.pt.2017.02.004. PMC 5446326. PMID 28285851.
  2. ↑ Campbell WC (May 2012). "History of avermectin and ivermectin, with notes on the history of other macrocyclic lactone antiparasitic agents". Current Pharmaceutical Biotechnology. 13 (6): 853–865. doi:10.2174/138920112800399095. PMID 22039784.
  3. 1 2 Saunders Handbook of Veterinary Drugs: Small and Large Animal (4 ed.). Elsevier Health Sciences. 2015. p. 420. ISBN 978-0-323-24486-2. Archived from the original on January 31, 2016.
  4. ↑ Molyneux DH, Ward SA (December 2015). "Reflections on the Nobel Prize for Medicine 2015—The Public Health Legacy and Impact of Avermectin and Artemisinin". Trends in Parasitology. 31 (12): 605–607. doi:10.1016/j.pt.2015.10.008. PMID 26552892.
  5. 1 2 3 4 "Ivermectin". The American Society of Health-System Pharmacists. Archived from the original on January 3, 2016. Retrieved January 16, 2016.
  6. ↑ Sneader W (2005). Drug Discovery a History. Chichester: John Wiley & Sons. p. 333. ISBN 978-0-470-01552-0. Archived from the original on June 15, 2020. Retrieved April 5, 2020.
  7. ↑ "Ascariasis – Resources for Health Professionals". U.S. Centers for Disease Control and Prevention (CDC). August 23, 2019. Archived from the original on November 21, 2010. Retrieved December 28, 2019.
  8. ↑ Panahi Y, Poursaleh Z, Goldust M (2015). "The efficacy of topical and oral ivermectin in the treatment of human scabies" (PDF). Annals of Parasitology. 61 (1): 11–16. PMID 25911032. Archived (PDF) from the original on April 4, 2020.
  9. ↑ "The Nobel Prize in Physiology or Medicine 2015" (PDF). Nobel Foundation. Archived from the original (PDF) on October 6, 2015. Retrieved October 7, 2015.
  10. ↑ World Health Organization (2025). The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines, 24th list. Geneva: World Health Organization. doi:10.2471/B09474. hdl:10665/382243. License: CC BY-NC-SA 3.0 IGO.
  11. ↑ Ahmed S, Karim MM, Ross AG, Hossain MS, Clemens JD, Sumiya MK, Phru CS, Rahman M, Zaman K, Somani J, Yasmin R, Hasnat MA, Kabir A, Aziz AB, Khan WA (February 2021). "A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness". International Journal of Infectious Diseases. 103: 214–216. doi:10.1016/j.ijid.2020.11.191. PMC 7709596. PMID 33278625.
  12. ↑ "The Top 300 of 2023". ClinCalc. Archived from the original on August 17, 2025. Retrieved August 17, 2025.
  13. ↑ "Ivermectin Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved August 17, 2025.
  14. ↑ "Ivermectin: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on November 28, 2021. Retrieved September 26, 2021.
  15. ↑ "Ivermectin lotion: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on September 26, 2021. Retrieved September 25, 2021.
  16. ↑ "Ivermectin/Albendazole - opinion on medicine for use outside EU". European Medicines Agency (EMA). January 30, 2025. Retrieved February 16, 2025.
  17. ↑ Evershed N, McGowan M, Ball A (March 10, 2021). "Anatomy of a conspiracy theory: how misinformation travels on Facebook". The Guardian. Archived from the original on March 18, 2023. Retrieved May 26, 2021.
  18. ↑ "Fact-checking claim about the use of ivermectin to treat COVID-19". PolitiFact. Washington, DC. April 23, 2021. Archived from the original on March 18, 2023. Retrieved May 26, 2021.
  19. ↑ Popp M, Reis S, Schießer S, Hausinger RI, Stegemann M, Metzendorf MI, Kranke P, Meybohm P, Skoetz N, Weibel S (June 2022). "Ivermectin for preventing and treating COVID-19". The Cochrane Database of Systematic Reviews. 2022 (6) CD015017. doi:10.1002/14651858.CD015017.pub3. PMC 9215332. PMID 35726131.
  20. 1 2 3 "EMA advises against use of ivermectin for the prevention or treatment of COVID-19 outside randomised clinical trials". European Medicines Agency. March 22, 2021. Archived from the original on January 17, 2022. Retrieved December 15, 2022.
  21. ↑ Garegnani LI, Madrid E, Meza N (April 2021). "Misleading clinical evidence and systematic reviews on ivermectin for COVID-19". BMJ Evidence-Based Medicine. 27 (3): 156–158. doi:10.1136/bmjebm-2021-111678. PMID 33888547.
  22. ↑ "Why You Should Not Use Ivermectin to Treat or Prevent COVID-19". U.S. Food and Drug Administration (FDA). December 10, 2021. Archived from the original on August 6, 2021. Retrieved July 13, 2021.
  23. ↑ "Rapid Increase in Ivermectin Prescriptions and Reports of Severe Illness Associated with Use of Products Containing Ivermectin to Prevent or Treat COVID-19" (PDF). CDC Health Alert Network. CDCHAN-00449. August 26, 2021. Archived (PDF) from the original on November 3, 2021. Retrieved January 4, 2022.
  24. ↑ "WHO advises that ivermectin only be used to treat COVID-19 within clinical trials". World Health Organization (WHO). Archived from the original on August 5, 2021. Retrieved January 4, 2022.
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