Kaposi's sarcoma
| Subclass of | connective tissue neoplasm, human herpesvirus 8 infectious disease  |
|---|---|
| Dem name after | Mór Kaposi |
| Has cause | Kaposi's sarcoma-associated herpesvirus, carcinogenesis |
| Discoverer or inventor | Mór Kaposi |
| Health specialty | oncology |
| Medical examination | physical examination, biopsy, computed tomography, histology |
| Disease transmission process | droplet transmission, contact transmission, haemocontact transmission of pathogen |
Kaposi's sarcoma (KS) be a type of cancer wey fi form masses on de skin, insyd lymph nodes, insyd de mouth, anaa insyd oda organs.[1][2] De skin lesions usually be painless, purple, den fi be flat anaa raised.[2][3] Lesions fi occur singly, multiply insyd a limited area, anaa fi be widespread.[2] Dey depend on de sub-type of disease den level of immune suppression, KS fi worsen either gradually anaa quickly.[2] Except for classic KS wer der be generally no immune suppression, KS be caused by a combination of immune suppression (such as HIV/AIDS) den infection by Human herpesvirus 8 (HHV8 – dem sanso call KS-associated herpesvirus (KSHV)).[3]
Classic, endemic, immunosuppression therapy-related (dem sanso know as iatrogenic), den epidemic (dem sanso know as AIDS-related) sub-types all be described.[3] Classic KS dey tend to affect older men insyd regions wer KSHV be highly prevalent (Mediterranean, Eastern Europe, Middle East), usually be slow-growing, den most often dey affect de legs per.[3] Endemic KS be most common insyd Sub-Saharan Africa wey e be more aggressive insyd kiddies, while older adults present similarly to classic KS.[3] Immunosuppression therapy-related KS generally dey occur insyd people dey follow organ transplantation den mostly dey affect de skin.[3] Epidemic KS dey occur insyd people plus AIDS den chaw parts of de body fi be affected.[3] KS be diagnosed by tissue biopsy, while de extent of disease fi be determined by medical imaging.[1][2][3]
Treatment be based on de sub-type, whether de condition be localized anaa widespread, den de person ein immune function.[2] Localized skin lesions fi be treated by surgery, injections of chemotherapy into de lesion, anaa radiation therapy.[2] Widespread disease fi be treated plus chemotherapy anaa biologic therapy.[1][2] Insyd those plus HIV/AIDS, highly active antiretroviral therapy (HAART) dey prevent den often dey treat KS.[3][4] Insyd certain cases de addition of chemotherapy fi be required.[4] Plus widespread disease, death fi occur.[2]
De condition be relatively common insyd people plus HIV/AIDS den dey follow organ transplants.[2][3][5] Over 35% of people plus AIDS fi be affected.[6] Na dem first describe KS by Moritz Kaposi insyd 1872,[7][8] buh na dem coin de name only insyd 1891. E cam be more widely known as one of de AIDS-defining illnesses insyd de 1980s.[7] Na dem discover KSHV as a causative agent insyd 1994.[7][9]
References
[edit | edit source]- 1 2 3 "Kaposi Sarcoma Treatment". National Cancer Institute (in English). 16 June 2017.
- 1 2 3 4 5 6 7 8 9 10 Schwartz RA, Micali G, Nasca MR, Scuderi L (August 2008). "Kaposi sarcoma: a continuing conundrum". Journal of the American Academy of Dermatology. 59 (2): 179–206, quiz 207–8. doi:10.1016/j.jaad.2008.05.001. PMID 18638627.
- 1 2 3 4 5 6 7 8 9 10 Cesarman E, Damania B, Krown SE, Martin J, Bower M, Whitby D (January 2019). "Kaposi sarcoma". Nature Reviews. Disease Primers. 5 (1) 9. doi:10.1038/s41572-019-0060-9. PMC 6685213. PMID 30705286.
- 1 2 Hoffmann C, Sabranski M, Esser S (2017). "HIV-Associated Kaposi's Sarcoma". Oncology Research and Treatment. 40 (3): 94–98. doi:10.1159/000455971. PMID 28259888. S2CID 9700628.
- ↑ Hoffmann C, Sabranski M, Esser S (2017). "HIV-Associated Kaposi's Sarcoma". Oncology Research and Treatment. 40 (3): 94–98. doi:10.1159/000455971. PMID 28259888. S2CID 9700628.
- ↑ Ferri FF (2017). Ferri's Clinical Advisor 2018 E-Book: 5 Books in 1 (in English). Elsevier Health Sciences. p. 735. ISBN 9780323529570.
- 1 2 3 "Kaposi Sarcoma Treatment". National Cancer Institute (in English). 1 October 2015. Retrieved 18 December 2017.
- ↑ Kaposi M (1872). "Idiopathisches multiples Pigmentsarkom der Haut". Archiv für Dermatologie und Syphilis. 4 (2): 265–273. doi:10.1007/BF01830024. S2CID 31438763.
- ↑ Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS (December 1994). "Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma". Science. 266 (5192): 1865–1869. Bibcode:1994Sci...266.1865C. doi:10.1126/science.7997879. PMID 7997879. S2CID 29977325.
External links
[edit | edit source]
- Kaposi sarcoma photo library at Dermnet (Archived 2010-11-08 at the Wayback Machine)
