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Lamotrigine

From Wikipedia
lamotrigine
type of chemical entity
Subclass ofanticonvulsant agent Edit
Get useMedication Edit
Stylized namelamoTRIgine, LaMICtal Edit
Chemical formulaC₉H₇Cl₂N₅ Edit
Canonical SMILESC1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N Edit
Active ingredient inLamictal Edit
World Health Organisation international non-proprietary namelamotrigine Edit
Significant drug interactionparacetamol Edit
Legal status (medicine)boxed warning Edit
Pregnancy categoryAustralian pregnancy category D, US pregnancy category C Edit
LiverTox likelihood scoreLiverTox toxicity likelihood category A Edit
Subject has roleexcitatory amino acid antagonist, anticonvulsant agent, calcium channel blocker, voltage-gated sodium channel blockers, essential medicine Edit

Lamotrigine (/ləˈmoʊtrɪˌdʒiːn/ luh-MOH-trih-jeen), dem sell under de brand name Lamictal among odas, be a medication dem use to treat epilepsy den stabilize mood insyd bipolar disorder.[1][2] For epilepsy, dis dey include focal seizures, tonic-clonic seizures, den seizures insyd Lennox-Gastaut syndrome.[2] Insyd bipolar disorder, na dem no show lamotrigine to reliably treat acute depression insyd any groups except for de severely depressed; buh for patients plus bipolar disorder wey no be currently symptomatic, e dey appear to reduce de risk of future episodes of depression.[3] Dem sanso dey use lamotrigine off label for unipolar depression (major depressive disorder) den depersonalization-derealization disorder.[4]

Common side effects dey include nausea, sleepiness, headache, vomiting, trouble plus coordination, den rash.[2] Serious side effects dey include excessive breakdown of red blood cells, increased risk of suicide, severe skin reaction (Stevens–Johnson syndrome), den allergic reactions, wich fi be fatal.[2] Lamotrigine be a phenyltriazine,[1] wey dey make am chemically different from oda anticonvulsants.[2] Ein mechanism of action no be clear, buh e dey appear to inhibit release of excitatory neurotransmitters via voltage-sensitive sodium channels den voltage-gated calcium channels insyd neurons.[2][5][6]

Na dem first market lamotrigine insyd Ireland insyd 1991,[7] wey na dem approve for use insyd de United States insyd 1994.[2][8] E dey on de World Health Organization's List of Essential Medicines.[9] Insyd 2023, na e be de most commonly prescribed mood stabilizer den 59th most commonly prescribed medication insyd de United States, plus more dan 10 million prescriptions.[10][11]

References

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  1. 1 2 "Lamictal- lamotrigine tablet Lamictal- lamotrigine tablet, for suspension Lamictal ODT- lamotrigine tablet, orally disintegrating Lamictal- lamotrigine kit". DailyMed. 13 April 2022. Archived from the original on 27 August 2022. Retrieved 27 August 2022.
  2. 1 2 3 4 5 6 7 "Lamotrigine". The American Society of Health-System Pharmacists. Archived from the original on 10 December 2017. Retrieved 8 December 2017.
  3. ↑ "Lamotrigine: Its Role in Bipolar Disorder". PsychiatricTimes. 26 November 2019. Archived from the original on 26 January 2021. Retrieved 1 September 2020.
  4. ↑ Wang S, Zheng S, Zhang FX, Ma R, Feng S, Song M, Zhu H, Jia H (2024). "The Treatment of Depersonalization-Derealization Disorder: A Systematic Review". Journal of Trauma & Dissociation. 25 (1): 6–29. doi:10.1080/15299732.2023.2231920. PMID 37431255.
  5. ↑ "Lamotrigine". PubChem Open Chemistry Database. US: National Institutes of Health. Archived from the original on 6 September 2016. Retrieved 13 December 2016.
  6. ↑ Goldsmith DR, Wagstaff AJ, Ibbotson T, Perry CM (1 October 2003). "Lamotrigine: a review of its use in bipolar disorder". Drugs. 63 (19): 2029–2050. doi:10.2165/00003495-200363190-00009. PMID 12962521.
  7. ↑ Weisler RH, Calabrese JR, Bowden CL, Ascher JA, DeVeaugh-Geiss J, Evoniuk G (May 2008). "Discovery and development of lamotrigine for bipolar disorder: a story of serendipity, clinical observations, risk-taking, and persistence". Journal of Affective Disorders. 108 (1–2): 1–9. doi:10.1016/j.jad.2007.09.012. PMID 18001843.
  8. ↑ Shorvon SD, Perucca E, Engel J (2015). The Treatment of Epilepsy (4th ed.). John Wiley & Sons, Incorporated. p. 1321. ISBN 978-1-118-93699-3. Archived from the original on 2 August 2021. Retrieved 31 August 2020.
  9. ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  10. ↑ "The Top 300 of 2023". clincalc.com. Archived from the original on 12 August 2025. Retrieved 13 August 2025.
  11. ↑ "Lamotrigine - Drug Usage Statistics, ClinCalc DrugStats Database". clincalc.com. Retrieved 13 August 2025.
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