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Lidocaine

From Wikipedia
lidocaine
type of chemical entity
Subclass ofamides Edit
Get useMedication Edit
Chemical formulaC₁₄H₂₂N₂O Edit
Canonical SMILESCCN(CC)CC(=O)NC1=C(C=CC=C1C)C Edit
Isomeric SMILESCCN(CC)C/C(=N\C1=C(C=CC=C1C)C)/O Edit
Pregnancy categoryAustralian pregnancy category A, US pregnancy category B Edit
Get characteristicbitterness Edit
Subject has roleantiarrhythmic agent, local anesthetic, voltage-gated sodium channel blockers, essential medicine Edit
WordLift URLhttp://data.wordlift.io/wl01714/entity/lidocaine.html Edit

Lidocaine, dem sanso know as lignocaine dem sell under de brand name Xylocaine among odas, be a local anesthetic of de amino amide type.[1] E sanso be used to treat ventricular tachycardia den ventricular fibrillation.[2][3] Wen used for local anaesthesia anaa insyd nerve blocks, lidocaine typically begin dey work within several minutes den dey last for half an hour to three hours.[3][4] Lidocaine mixtures sanso fi be applied directly to de skin anaa mucous membranes to numb de area.[1][3] E often be used dem mix plus a small amount of adrenaline (epinephrine) to prolong ein local effects den to decrease bleeding.[3]

If dem inject am intravenously, e fi cause cerebral effects such as confusion, changes insyd vision, numbness, tingling, den vomiting.[1][2] E fi cause low blood pressure den an irregular heart rate.[2] Der be concerns say injecting am into a joint fi cause problems plus de cartilage.[3] E dey appear to be generally safe for use insyd pregnancy.[2] A lower dose fi be required insyd those plus liver problems.[2] E be generally safe to use insyd those allergic to tetracaine anaa benzocaine.[3] Lidocaine be an antiarrhythmic medication of de class Ib type.[2] Dis dey mean e dey work by blocking sodium channels thus dey decrease de rate of contractions of de heart.[1][2] Wen dem inject am near nerves, de nerves no fi conduct signals to anaa from de brain.[3]

Dem discover lidocaine insyd 1946 wey e go on sale insyd 1948.[5] E dey on de World Health Organization's List of Essential Medicines.[6] E be available as a generic medication.[3][7] Insyd 2023, e be de 277th most commonly prescribed medication insyd de United States, plus more dan 800,000 prescriptions.[8][9]

References

[edit | edit source]
  1. 1 2 3 4 Beecham GB, Nessel TA, Goyal A (11 December 2022). "Lidocaine". StatPearls, US National Library of Medicine. Retrieved 23 July 2024.
  2. 1 2 3 4 5 6 7 "Lidocaine Hydrochloride (Antiarrhythmic)". Drugs.com, The American Society of Health-System Pharmacists. 10 June 2024. Retrieved 23 July 2024.
  3. 1 2 3 4 5 6 7 8 "Lidocaine Hydrochloride (Local)". Drugs.com, The American Society of Health-System Pharmacists. 22 January 2024. Retrieved 23 July 2024.
  4. ↑ Nolan JP, Baskett PJ (1997). "Analgesia and anaesthesia". In Skinner D, Swain A, Peyton R, Robertson C, Whinster F (eds.). Cambridge Textbook of Accident and Emergency Medicine. Cambridge, UK: Cambridge University Press. p. 194. ISBN 978-0-521-43379-2. Archived from the original on 8 September 2017.
  5. ↑ Scriabine A (1999). "Discovery and development of major drugs currently in use". In Landau R, Achilladelis B, Scriabine A (eds.). Pharmaceutical Innovation: Revolutionizing Human Health. Philadelphia: Chemical Heritage Press. p. 211. ISBN 978-0-941901-21-5. Archived from the original on 8 September 2017.
  6. ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  7. ↑ Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 22. ISBN 978-1-284-05756-0.
  8. ↑ "The Top 300 of 2023". ClinCalc. Archived from the original on 17 August 2025. Retrieved 17 August 2025.
  9. ↑ "Lidocaine Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 17 August 2025.
[edit | edit source]
  • "Lidocaine Transdermal Patch". MedlinePlus.
  • US patent 2441498, Nils Magnus Loefgren & Bengt Josef Lundqvist, "Alkyl glycinanilides", published 1948-05-11, issued 1948-05-11, assigned to ASTRA APOTEKARNES KEM FAB 
Dem retrieve am from "https://gpe.wikipedia.org/w/index.php?title=Lidocaine&oldid=97492"