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Lisdexamfetamine

From Wikipedia
lisdexamfetamine
type of chemical entity
Subclass ofN-substituted primary carboxamide, diamine, phenyl compound Edit
Get useMedication Edit
Chemical formulaC₁₅H₂₅N₃O Edit
Canonical SMILESCC(CC1=CC=CC=C1)NC(=O)C(CCCCN)N Edit
Isomeric SMILESC[C@@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCCN)N Edit
Active ingredient inVyvanse, Venvanse, Aduvanz, Elvanse Edit
World Health Organisation international non-proprietary namelisdexamfetamine Edit
Medical condition treatednarcolepsy, attention deficit hyperactivity disorder, binge eating disorder Edit
Legal status (medicine)boxed warning Edit
Pregnancy categoryAustralian pregnancy category B3, US pregnancy category C Edit
ManufacturerTakeda Pharmaceutical Company Edit
Subject has roleserotonergic agent, nootropic Edit

Lisdexamfetamine, dem sell under de brand names Vyvanse den Elvanse among odas, be a stimulant medication wey dem dey use as a treatment for attention deficit hyperactivity disorder (ADHD) insyd kiddies den adults den for moderate-to-severe binge eating disorder insyd adults.[1] A prodrug of dextroamphetamine, dem dey take lisdexamfetamine by mouth. Ein effects generally dey begin within 90 minutes den dey last for up to 14 hours.[1]

Common side effects of lisdexamfetamine dey include loss of appetite, anxiety, diarrhea, trouble sleeping, irritability, den nausea.[1] Rare buh serious side effects dey include mania, sudden cardiac death insyd those plus underlying heart problems, den psychosis.[1] E get a high potential for substance abuse.[1] Serotonin syndrome fi occur if dem use am plus certain oda medications.[1] Ein use during pregnancy fi result in harm to de baby wey na ein use during breastfeeding no be recommended by de manufacturer.[1][2][3]

Lisdexamfetamine be an inactive prodrug wey be formed by de condensation of L-lysine, a naturally wey dey occur amino acid, den dextroamphetamine.[4] Insyd de body, metabolic action dey reverse dis process to release de active agent, de central nervous system (CNS) stimulant dextroamphetamine.[1][5]

Na dem approve lisdexamfetamine for medical use insyd de United States insyd 2007 den insyd de European Union insyd 2012.[6][7] Insyd 2023, na e be de 76th most commonly prescribed medication insyd de United States, plus more dan 9 million prescriptions.[8][9] E be a Class B controlled substance insyd de United Kingdom, a Schedule 8 controlled drug insyd Australia, den a Schedule II controlled substance insyd de United States.[2][10]

References

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  1. 1 2 3 4 5 6 7 8 "Lisdexamfetamine Dimesylate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 15 April 2019.
  2. 1 2 British national formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 348–349. ISBN 978-0-85711-338-2.
  3. ↑ "Lisdexamfetamine (Vyvanse) Use During Pregnancy". Drugs.com. Retrieved 16 April 2019.
  4. ↑ Blick SK, Keating GM (2007). "Lisdexamfetamine". Paediatric Drugs. 9 (2): 129–135, discussion 136–138. doi:10.2165/00148581-200709020-00007. PMID 17407369. S2CID 260863254.
  5. ↑ Heal DJ, Smith SL, Gosden J, Nutt DJ (June 2013). "Amphetamine, past and present--a pharmacological and clinical perspective". Journal of Psychopharmacology. 27 (6): 479–496. doi:10.1177/0269881113482532. PMC 3666194. PMID 23539642.
  6. ↑ "Lisdexamfetamine Dimesylate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 15 April 2019.
  7. ↑ "Shire's ADHD amphetamine wins British backing". Reuters. 12 December 2012. Retrieved 14 December 2023.
  8. ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  9. ↑ "Lisdexamfetamine Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved 18 August 2025.
  10. ↑ Drugs of Abuse (PDF). Drug Enforcement Administration • U.S. Department of Justice. 2017. p. 22. Retrieved 16 April 2019.
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