Lisinopril
| Subclass of | heterocyclic compound, carboxylic acid  |
|---|---|
| Get use | Medication |
| Stereoisomer of | lisinopril R,S,S-isomer |
| Chemical formula | C₂₁H₃₁N₃O₅ |
| Canonical SMILES | C1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O |
| Isomeric SMILES | C1C[C@H](N(C1)C(=O)[C@H](CCCCN)N[C@@H](CCC2=CC=CC=C2)C(=O)O)C(=O)O |
| Medical condition treated | congestive heart failure, Hypertension, acute myocardial infarction, Hypertension |
| Legal status (medicine) | boxed warning |
| LiverTox likelihood score | LiverTox toxicity likelihood category B |
| Subject has role | antihypertensive drug, cardiotonic, ACE inhibitor |
Lisinopril be a medication wey dey belong to de drug class of angiotensin-converting enzyme (ACE) inhibitors wey e be used to treat hypertension (high blood pressure), heart failure, den heart attacks.[1] For high blood pressure e usually be a first-line treatment. Dem sanso dey use am to prevent kidney problems insyd people plus diabetes mellitus.[1] Dem dey take lisinopril orally (dem swallow by mouth).[1] Full effect fi take up to four weeks to occur.[1]
Common side effects dey include headache, dizziness, feeling tired, cough, nausea, den rash.[1] Serious side effects fi include low blood pressure, liver problems, hyperkalemia (high blood potassium), den angioedema.[1] Ein use no be recommended during de entire duration of pregnancy as e fi harm de baby.[1] Lisinopril dey work by inhibiting de renin–angiotensin–aldosterone system.[1]
Dem patent lisinopril insyd 1978 wey dem approve am for medical use insyd de United States insyd 1987.[1][2] E be available as a generic medication.[1] Insyd 2023, na e be de fourth most commonly prescribed medication insyd de United States, plus more dan 76 million prescriptions.[3][4] E be available in combination plus amlodipine (as lisinopril/amlodipine) den in combination plus hydrochlorothiazide (as lisinopril/hydrochlorothiazide).
References
[edit | edit source]- 1 2 3 4 5 6 7 8 9 10 "Lisinopril Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 23 December 2018.
- ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 467. ISBN 978-3-527-60749-5.
- ↑ "The Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
- ↑ "Lisinopril Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 12 August 2025.
External links
[edit | edit source]
- Fogari R, Zoppi A, Corradi L, Lazzari P, Mugellini A, Lusardi P (November 1998). "Comparative effects of lisinopril and losartan on insulin sensitivity in the treatment of non diabetic hypertensive patients". Br J Clin Pharmacol. 46 (5): 467–71. doi:10.1046/j.1365-2125.1998.00811.x. PMC 1873694. PMID 9833600.
- Bussien JP, Waeber B, Nussberger J, Gomez HJ, Brunner HR (1985). "Once-daily lisinopril in hypertensive patients: Effect on blood pressure and the renin–angiotensin system". Curr Therap Res. 37: 342–51.