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Loratadine

From Wikipedia
loratadine
type of chemical entity
Subclass ofpyridine, piperidine, carbamate, monochlorobenzene Edit
Get useMedication Edit
Chemical formulaC₂₂H₂₃ClN₂O₂ Edit
Canonical SMILESCCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1 Edit
World Health Organisation international non-proprietary nameloratadine Edit
Found insyd taxonPenicillium granulatum Edit
Medical condition treatedurticaria, seasonal allergic rhinitis, paranasal sinus disease, nasopharyngitis, sinusitis Edit
Physically dey interact plusSolute carrier family 6 member 15, Histamine receptor H1 Edit
Legal status (medicine)boxed warning Edit
Pregnancy categoryAustralian pregnancy category B1, US pregnancy category B Edit
LiverTox likelihood scoreLiverTox toxicity likelihood category E* Edit
Subject has roleH1 antagonist, anti-allergic agents, non-sedating histamine H1 antagonist, antipruritic, essential medicine Edit

Loratadine, dem sell under de brand name Claritin among odas, be a medication dem use to treat allergies.[1] Dis dey include allergic rhinitis (hay fever) den hives.[1] E sanso be available insyd drug combinations such as loratadine/pseudoephedrine, insyd wich e be combined plus pseudoephedrine, a nasal decongestant.[1] Dem dey take am orally.[1]

Common side effects dey include sleepiness, dry mouth, den headache.[1] Serious side effects be rare den dey include allergic reactions, seizures, den liver problems.[2] Ein use during pregnancy appear to be safe buh e no be well studied.[3] E no be recommended insyd kiddies less dan two years old.[2] E dey insyd de second-generation antihistamine family of medications.[1]

Dem patent loratadine insyd 1980 wey e cam to market insyd 1988.[4] E dey on de World Health Organization's List of Essential Medicines.[5] Loratadine be available as a generic medication.[1][6] Insyd de United States, e be available over de counter.[1] Insyd 2023, na e be de 105th most commonly prescribed medication insyd de United States, plus more dan 6 million prescriptions;[7][8] den de combination plus pseudoephedrine be de 300th most commonly prescribed medication insyd de United States, plus more dan 400,000 prescriptions.[9]

References

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  1. 1 2 3 4 5 6 7 8 "Loratadine". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
  2. 1 2 "Clarityn Allergy 10mg Tablets (P) - Summary of Product Characteristics (SmPC) - (eMC)". www.medicines.org.uk. 7 October 2015. Archived from the original on 20 December 2016. Retrieved 13 December 2016.
  3. ↑ "Loratadine Use During Pregnancy". www.drugs.com. Archived from the original on 21 December 2016. Retrieved 13 December 2016.
  4. ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 549. ISBN 9783527607495.
  5. ↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  6. ↑ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 3 March 2023. Archived from the original on 20 February 2020. Retrieved 6 March 2023.
  7. ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  8. ↑ "Loratadine Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 18 August 2025.
  9. ↑ "Loratadine; Pseudoephedrine Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 18 August 2025.
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