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Losartan

From Wikipedia
losartan
type of chemical entity
Subclass ofheterocyclic compound Edit
Get useMedication Edit
Chemical formulaC₂₂H₂₃ClN₆O Edit
Canonical SMILESCCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl Edit
Active ingredient inCozaar Edit
World Health Organisation international non-proprietary namelosartan Edit
Medical condition treatedcongestive heart failure, Hypertension Edit
Physically dey interact plusangiotensin II receptor type 1 Edit
Legal status (medicine)boxed warning Edit
Pregnancy categoryAustralian pregnancy category D, US pregnancy category D Edit
LiverTox likelihood scoreLiverTox toxicity likelihood category C Edit
Subject has roleangiotensin II receptor antagonist, antiarrhythmic agent, antihypertensive drug, essential medicine Edit

Losartan, dem sell under de brand name Cozaar among odas, be a medication dem use to treat high blood pressure (hypertension).[1] E dey insyd de angiotensin receptor blocker (ARB) family of medication, wey e be considered protective of de kidneys. Besides hypertension, e sanso be used insyd diabetic kidney disease, heart failure, den left ventricular enlargement.[1] E dey cam as a tablet wey dem dey take by mouth.[1] E fi be used alone anaa in addition to oda blood pressure medication.[1] Up to six weeks fi be required for de full effects to occur.[1]

Common adverse effects dey include muscle cramps, stuffy nose, dizziness, cough, high blood potassium, den anemia.[1] Severe adverse effects fi include angioedema, low blood pressure, den kidney problems.[1] Use during pregnancy fi result in harm to de baby.[1][2] Use no be recommended during breastfeeding.[2] E dey work by blocking angiotensin II.[1]

Dem patent losartan insyd 1986, wey dem approve am for medical use insyd de United States insyd 1995.[1][3] E dey on de World Health Organization's List of Essential Medicines.[4] E be available as a generic medication.[5] Insyd 2023, na e be de eighth most commonly prescribed medication insyd de United States, plus more dan 56 million prescriptions.[6][7] A version dem combine plus de diuretic hydrochlorothiazide be available[1] wich, insyd 2023, na e be de 65th most commonly prescribed medication insyd de United States, plus more dan 9 million prescriptions.[6][8]

References

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  1. 1 2 3 4 5 6 7 8 9 10 11 "Losartan Potassium". The American Society of Health-System Pharmacists. Archived from the original on 10 December 2017. Retrieved 8 December 2017.
  2. 1 2 "Losartan (Cozaar) Use During Pregnancy". Drugs.com. Archived from the original on 10 December 2017. Retrieved 10 December 2017.
  3. ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 470. ISBN 978-3-527-60749-5. Archived from the original on 28 August 2021. Retrieved 26 August 2020.
  4. ↑ The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. 2023. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  5. ↑ British national formulary: BNF 69 (69 ed.). British Medical Association. 2015. p. 127. ISBN 978-0-85711-156-2.
  6. 1 2 "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  7. ↑ "Losartan Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 12 August 2025.
  8. ↑ "Hydrochlorothiazide; Losartan Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 12 August 2025.

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