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Lupus

From Wikipedia
lupus
designated intractable/rare disease, rare disease, class of disease, signs den symptoms
Subclass ofrheumatism, lupus erythematosus, connective tissue disease, disease Edit
Dem name afterCanis lupus Edit
Health specialtyimmunology, rheumatology, dermatology Edit
Medical examinationLupus band test Edit
External data available at URLhttp://www.nanbyou.or.jp/entry/53 Edit
Risk factorfemale Edit
ICD-9-CM710.0 Edit
ICPC 2 IDL99 Edit
NCI Thesaurus IDC3201 Edit

Lupus, dem formally call systemic lupus erythematosus (SLE), be an autoimmune disease insyd wich de body ein immune system mistakenly dey attack healthy tissue insyd chaw parts of de body.[1] Symptoms dey vary among people den fi be mild to severe.[1] Common symptoms dey include painful den swollen joints, fever, chest pain, hair loss, mouth ulcers, swollen lymph nodes, dey feel tired, den a red rash wich be most commonly on de face.[1] Often der be periods of illness, dem call flares, den periods of remission during wich der be few symptoms.[1] Kiddies up to 18 years old dey develop a more severe form of SLE dem term childhood-onset systemic lupus erythematosus.[2]

Lupus be Latin for 'wolf': na dem so-name de disease insyd de 13th century as na dem think de rash dey appear like a wolf ein bite.[3]

De cause of SLE no be clear.[1] Dem dey think to involve a combination of genetics den environmental factors.[4] Among identical twins, if one be affected der be a 24% chance de oda one sanso go develop de disease.[1] Dem dey believe female sex hormones, sunlight, smoking, vitamin D deficiency, den certain infections to increase a person ein risk.[4] De mechanism dey involve an immune response by autoantibodies against a person ein own tissues.[1] Dese be most commonly anti-nuclear antibodies wey dem dey result in inflammation.[1] Diagnosis fi be difficult wey e base on a combination of symptoms den laboratory tests.[1] Der be a number of oda kinds of lupus erythematosus wey dey include discoid lupus erythematosus, neonatal lupus, den subacute cutaneous lupus erythematosus.[1]

Der be no cure for SLE,[1] buh der be experimental den symptomatic treatments.[5] Treatments fi include NSAIDs, corticosteroids, immunosuppressants, hydroxychloroquine, den methotrexate.[1] Although corticosteroids be rapidly effective, long-term use dey result in side effects.[6] Alternative medicine no show to affect de disease.[1] Men get higher mortality.[7] SLE significantly dey increase de risk of cardiovascular disease, wey dis be de most common cause of death.[4] While women plus lupus get higher-risk pregnancies, chaw be successful.[1]

Rate of SLE dey vary between countries from 20 to 70 per 100,000.[8] Women of childbearing age be affected about nine times more often dan men.[4] While e most commonly dey begin between de ages of 15 den 45, a wide range of ages fi be affected.[1][8] Those of African, Caribbean, den Chinese descent be at higher risk dan those of European descent.[4][8] Rates of disease insyd de developing world be unclear.[9]

Famous cases

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  • Shannon Boxx, U.S. Olympic team soccer player[10]
  • Nick Cannon, American television host, actor, rapper, den comedian[11]
  • Pumpuang Duangjan, Thai Luk Thung singer.[12] Chaw people know dis disease as "Phumpuang disease" secof she die from de disease.[13]
  • Selena Gomez, singer, actress, producer, den businesswoman[14]
  • Sally Hawkins, actress[15]
  • Flannery O'Connor, Southern Gothic novelist den short-story author[16]
  • Michael Jackson, American singer, songwriter, dancer den philanthropist[17]
  • Seal, British singer[18]
  • Cori Broadus, business owner of beauty company Choc Factory, Snoop den Shante Broadus dema daughter.[19][20]
  • Toni Braxton, American singer, songwriter, actress den television personality[21]

References

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  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 "Handout on Health: Systemic Lupus Erythematosus". www.niams.nih.gov. February 2015. Archived from the original on 17 June 2016. Retrieved 12 June 2016.
  2. ↑ Sura A, Failing C, Co DO, Syverson G (June 2024). "Childhood-Onset Systemic Lupus Erythematosus". Pediatrics in Review. 45 (6): 316–328. doi:10.1542/pir.2023-006011. PMID 38821900.
  3. ↑ Chabner DE (2013). The Language of Medicine. Elsevier Health Sciences. p. 610. ISBN 978-1-4557-2846-6.
  4. 1 2 3 4 5 Lisnevskaia L, Murphy G, Isenberg D (November 2014). "Systemic lupus erythematosus". The Lancet. 384 (9957): 1878–1888. CiteSeerX 10.1.1.1008.5428. doi:10.1016/s0140-6736(14)60128-8. PMID 24881804. S2CID 28905456.
  5. ↑ "Five lupus patients enter long-lasting remission after immunotherapy". New Atlas (in American English). 2022-09-15. Retrieved 2022-09-17.
  6. ↑ Davis LS, Reimold AM (April 2017). "Research and therapeutics-traditional and emerging therapies in systemic lupus erythematosus". Rheumatology. 56 (suppl_1): i100 – i113. doi:10.1093/rheumatology/kew417. PMC 5850311. PMID 28375452.
  7. ↑ Murphy G, Isenberg D (December 2013). "Effect of gender on clinical presentation in systemic lupus erythematosus". Rheumatology. 52 (12): 2108–2115. doi:10.1093/rheumatology/ket160. PMID 23641038.
  8. 1 2 3 Danchenko N, Satia JA, Anthony MS (2006). "Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden". Lupus. 15 (5): 308–318. doi:10.1191/0961203306lu2305xx. PMID 16761508. S2CID 6465663.
  9. ↑ Tiffin N, Adeyemo A, Okpechi I (January 2013). "A diverse array of genetic factors contribute to the pathogenesis of systemic lupus erythematosus". Orphanet Journal of Rare Diseases. 8: 2. doi:10.1186/1750-1172-8-2. PMC 3551738. PMID 23289717.
  10. ↑ Wilson J (2012-08-16). "Olympic soccer player Shannon Boxx's battle with lupus". CNN (in English). Retrieved 2023-01-29.
  11. ↑ "The Male Faces of Lupus". Vice.com (in English). 5 January 2017. Retrieved 2023-01-29.
  12. ↑ ""ตุ๊ดอ้วน" DramaSomething: ปรากฏการณ์การจากไปของราชินีลูกทุ่ง พุ่มพวง ดวงจันทร์ สะท้อนภาพการเผยแพร่ข่าวสาร ในยุคสื่อไร้ Social Media และการทำงานของสื่อมวลชน". Drama Something. 2016. Retrieved 2025-11-22.
  13. ↑ "โรคพุ่มพวง โรคลูปัส โรคเอสแอลอี Lupus SLE - หาหมอ.com". 2019-06-01. Archived from the original on 2019-06-01. Retrieved 2025-02-20.
  14. ↑ "How Selena Gomez's lupus led to a kidney transplant". www.lupus.org.
  15. ↑ "Sally Hawkins". Lupus Trust UK. 6 December 2017.
  16. ↑ O'Connor, Flannery (1979). Fitzgerald, Sally (ed.). The Habit of Being: Letters of Flannery O'Connor. Farrar, Straus and Giroux. p. 40. ISBN 978-0-374-52104-2. (letter to Sally Fitzgerald, undated, summer 1952)
  17. ↑ Rosenberg A (2 February 2016). "To understand Michael Jackson and his skin, you have to go beyond race". The Washington Post. Retrieved 17 September 2019.
  18. ↑ Evans, Mel (5 July 2018). "Seal opens up about Lupus battle as he teams up with Myleene Klass and Nile Rodgers for NHS charity single". Metro. Retrieved 15 October 2023.
  19. ↑ "All About Snoop Dogg's Daughter Cori Broadus". People.com (in English). Retrieved 2025-08-30.
  20. ↑ Silva, Carly (2023-09-23). "Snoop Dogg's Daughter Provides Health Update Amid Lupus Battle". Parade (in English). Retrieved 2025-08-30.
  21. ↑ "Toni Braxton is a fighter of Lupus". Heal Good. Archived from the original on February 9, 2016. Retrieved January 23, 2016.
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