Methocarbamol
| Subclass of | chemical compound  |
|---|---|
| Get use | Medication |
| Chemical formula | C₁₁H₁₅NO₅ |
| Canonical SMILES | COC1=CC=CC=C1OCC(COC(=O)N)O |
| Active ingredient in | Robaxin |
| Medical condition treated | spasm, tetanus, pain, inflammatory myopathy, muscle cramp |
| Physically dey interact plus | Carbonic anhydrase 1 |
| Pregnancy category | Australian pregnancy category B2, US pregnancy category C |
| LiverTox likelihood score | LiverTox toxicity likelihood category E |
| Subject has role | central muscle relaxants |
Methocarbamol, dem sell under de brand name Robaxin among odas, be a medication dem use for short-term musculoskeletal pain.[1][2] E fi be used togeda plus rest, physical therapy, den pain medication.[1][3][4] E get limited use for rheumatoid arthritis den cerebral palsy.[1][5] Effects generally dey begin within half an hour.[1] Dem dey take am by mouth anaa injection into a vein.[1]
Common side effects dey include headaches, sleepiness, den dizziness.[1][6] Serious side effects fi include anaphylaxis, liver problems, confusion, den seizures.[2] Ein use no be recommended insyd pregnancy den breastfeeding.[1][2] Secof de risk of injury, skeletal muscle relaxants generally for be avoided insyd geriatric patients.[1] Methocarbamol be a centrally acting muscle relaxant.[1] How e dey works be unclear, buh e no dey appear to affect muscles directly.[1]
Dem develpo methocarbamol insyd 1956 insyd de laboratories of A. H. Robins (later be acquired by Pfizer). Na dem direct studies towards de development of propanediol derivatives wich possess muscle relaxant properties superior to those of mephenesin, wich get low potency den a short duration of action.[7] Na dem approve am for medical use insyd de United States insyd 1957.[8] E be available as a generic medication.[8][2] Insyd 2023, na e be de 121st most commonly prescribed medication insyd de United States, plus more dan 5 million prescriptions.[9][10] Methocarbamol be available insyd a fixed-dose combination plus ibuprofen as methocarbamol/ibuprofen (dem sell under de brand name Summit Ultra).[11]
References
[edit | edit source]- 1 2 3 4 5 6 7 8 9 10 "Methocarbamol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists.
- 1 2 3 4 British national formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1093. ISBN 978-0-85711-338-2.
- ↑ "Robaxin- methocarbamol tablet, film coated". DailyMed. 18 July 2019. Retrieved 19 April 2020.
- ↑ "Robaxin- methocarbamol injection". DailyMed. 10 December 2018. Retrieved 19 April 2020.
- ↑ Richards BL, Whittle SL, Buchbinder R (January 2012). "Muscle relaxants for pain management in rheumatoid arthritis". The Cochrane Database of Systematic Reviews. 1 (1) CD008922. doi:10.1002/14651858.CD008922.pub2. PMC 11702505. PMID 22258993. S2CID 73769165.
- ↑ "Methocarbamol". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 30 January 2017. PMID 31643609.
- ↑ Analytical Profiles of Drug Substances and Excipients, pp. 373
- 1 2 "Methocarbamol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists.
- ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
- ↑ "Methocarbamol Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved 18 August 2025.
- ↑ "Summit Ultra Product information". Health Canada. 2 August 2018. Retrieved 17 February 2025.
External links
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