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Midazolam

From Wikipedia
midazolam
type of chemical entity
Subclass ofbenzodiazepine drug Edit
Get useMedication Edit
Chemical formulaC₁₈H₁₃ClFN₃ Edit
Canonical SMILESCC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4F Edit
Active ingredient inBuccolam Edit
Medical condition treatedanxiety disorder, agitation in dementia, status epilepticus Edit
Physically dey interact plusAlpha-1B adrenergic receptor Edit
Legal status (medicine)boxed warning Edit
Pregnancy categoryAustralian pregnancy category C, US pregnancy category D Edit
LiverTox likelihood scoreLiverTox toxicity likelihood category E Edit
ManufacturerPfizer Edit
Substance control statusSchedule III (Russia), Schedule IV (Canada), Anlage III (Germany), Schedule IV (United States) Edit

Midazolam, dem sell under de brand name Versed among odas, be a benzodiazepine medication dem use give anesthesia, premedication before surgical anesthesia, den procedural sedation, den to treat severe agitation.[1] E dey induce sleepiness, dey decrease anxiety, den dey cause anterograde amnesia.[1]

De drug no dey cause an individual to become unconscious, merely to be sedated.[1] E sanso be useful for de treatment of prolonged (lasting over five minutes) seizures.[2] Dem fi give midazolam by mouth, intravenously, by injection into a muscle, by spraying into de nose, anaa thru de cheek.[1][2] Wen dem give intravenously, e typically dey begin dey work within five minutes; wen dem inject into a muscle, e fi take fifteen minutes to begin dey work;[1] wen dem take am orally, e fi take 10–20 minutes to begin dey work.[3]

Side effects fi include a decrease in efforts to breathe, low blood pressure, den sleepiness.[1] Tolerance to ein effects den withdrawal syndrome fi occur following long-term use.[4] Paradoxical effects, such as increased activity, fi occur especially insyd kiddies den older people.[4] Der be evidence of risk wen dem use during pregnancy buh no evidence of harm plus a single dose during breastfeeding.[5][6]

Dem patent midazolam insyd 1974 wey e cam into medical use insyd 1982.[7] E dey on de World Health Organization's List of Essential Medicines.[8] Midazolam be available as a generic medication.[9] Insyd chaw countries, e be a controlled substance.[1]

References

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  1. 1 2 3 4 5 6 7 "Midazolam Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 5 September 2015. Retrieved 1 August 2015.
  2. 1 2 Brigo F, Nardone R, Tezzon F, Trinka E (August 2015). "Nonintravenous midazolam versus intravenous or rectal diazepam for the treatment of early status epilepticus: A systematic review with meta-analysis". Epilepsy & Behavior. 49: 325–336. doi:10.1016/j.yebeh.2015.02.030. PMID 25817929. S2CID 33207030.
  3. ↑ "Midazolam, Midazolam Hydrochloride Monograph for Professionals". Drugs.com (in English). Retrieved 3 September 2024.
  4. 1 2 Riss J, Cloyd J, Gates J, Collins S (August 2008). "Benzodiazepines in epilepsy: pharmacology and pharmacokinetics". Acta Neurologica Scandinavica. 118 (2): 69–86. doi:10.1111/j.1600-0404.2008.01004.x. PMID 18384456. S2CID 24453988.
  5. ↑ Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 21. ISBN 978-1-284-05756-0.
  6. ↑ "Midazolam use while Breastfeeding". Archived from the original on 5 September 2015. Retrieved 29 August 2015.
  7. ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 539. ISBN 978-3-527-60749-5. Archived from the original on 30 November 2021. Retrieved 24 August 2020.
  8. ↑ The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. 2023. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  9. ↑ Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 21. ISBN 978-1-284-05756-0.
[edit | edit source]
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