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Mirtazapine

From Wikipedia
mirtazapine
type of chemical entity
Subclass ofchemical compound Edit
Get useMedication Edit
Chemical formulaC₁₇H₁₉N₃ Edit
Canonical SMILESCN1CCN2C(C1)C3=CC=CC=C3CC4=C2N=CC=C4 Edit
Active ingredient inRemeron Edit
Physically dey interact plus5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2C, Adrenoceptor alpha 2A, Adrenoceptor alpha 2B, Adrenoceptor alpha 2C Edit
Legal status (medicine)boxed warning Edit
Pregnancy categoryAustralian pregnancy category B3, US pregnancy category C Edit
Subject has rolemuscarinic antagonist, H1 antagonist, alpha blocker, tricyclic antidepressant Edit

Mirtazapine, dem sell under de brand name Remeron among odas, be an atypical tetracyclic antidepressant, den as such dem dey use am primarily to treat depression.[1][2] Ein effects fi take up to four weeks buh sanso fi manifest as early as one to two weeks.[2][3] Dem often dey use am insyd cases of depression wey be complicated by anxiety anaa insomnia.[1][4] De effectiveness of mirtazapine be comparable to oda commonly prescribed antidepressants.[5] Dem dey take am by mouth.[2]

Common side effects dey include sleepiness, dizziness, increased appetite, den weight gain.[2] Serious side effects fi include mania, low white blood cell count, den increased suicide among kiddies.[2] Withdrawal symptoms fi occur wen stopping.[6] Dem no dey recommend am togeda plus a monoamine oxidase inhibitor,[2] although evidence wey dey support de danger of dis combination be challenged.[7] E be unclear if use during pregnancy be safe.[2] How e dey work no be clear, buh e fi involve blocking certain adrenergic den serotonin receptors.[1][2] Chemically, e be a tetracyclic antidepressant,[2] wey e be closely related to mianserin. E sanso get strong antihistaminergic effects.[1][2]

Mirtazapine cam into medical use insyd de United States insyd 1996.[2] Na de patent expire insyd 2004, wey generic versions be available.[2][8] Insyd 2023, na e be de 99th most commonly prescribed medication insyd de United States, plus more dan 6 million prescriptions.[9][10]

References

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  1. 1 2 3 4 Anttila SA, Leinonen EV (2001). "A review of the pharmacological and clinical profile of mirtazapine". CNS Drug Reviews. 7 (3): 249–264. doi:10.1111/j.1527-3458.2001.tb00198.x. PMC 6494141. PMID 11607047.
  2. 1 2 3 4 5 6 7 8 9 10 11 12 "Mirtazapine Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 10 January 2021. Retrieved 20 November 2018.
  3. ↑ Watanabe N, Omori IM, Nakagawa A, Cipriani A, Barbui C, Churchill R, Furukawa TA (December 2011). "Mirtazapine versus other antidepressive agents for depression". The Cochrane Database of Systematic Reviews (12) CD006528. doi:10.1002/14651858.CD006528.pub2. PMC 4158430. PMID 22161405.
  4. ↑ Nutt DJ (June 2002). "Tolerability and safety aspects of mirtazapine". Human Psychopharmacology. 17 (Suppl 1): S37 – S41. doi:10.1002/hup.388. PMID 12404669. S2CID 23699759.
  5. ↑ "[129] Mirtazapine: Update on efficacy, safety, dose response". www.ti.ubc.ca. Archived from the original on 7 May 2021. Retrieved 8 May 2021.
  6. ↑ British national formulary: BNF 74 (74 ed.). British Medical Association. 2017. p. 354. ISBN 978-0-85711-298-9.
  7. ↑ Gillman PK (March 2006). "A systematic review of the serotonergic effects of mirtazapine in humans: implications for its dual action status". Human Psychopharmacology. 21 (2): 117–125. doi:10.1002/hup.750. PMID 16342227. S2CID 23442056.
  8. ↑ Schatzberg AF, Cole JO, DeBattista C (2010). "3". Manual of Clinical Psychopharmacology (7th ed.). Arlington, VA: American Psychiatric Publishing. ISBN 978-1-58562-377-8.
  9. ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  10. ↑ "Mirtazapine Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved 18 August 2025.
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