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Myalgic encephalomyelitis/chronic fatigue syndrome

From Wikipedia
chronic fatigue syndrome
class of disease, signs den symptoms
Subclass ofsyndrome, primary immunodeficiency disease, disease Edit
Has causeincognita, Human herpesvirus 6, Human herpesvirus 7, Borna disease virus, Epstein–Barr virus Edit
Health specialtyneurology, rheumatology Edit
Medical examinationphysical examination Edit
Possible treatmentrintatolimod, pyridostigmine Edit
Drug or therapy used for treatmentvenlafaxine, ubidecarenone, sodium oxybate, rintatolimod Edit
Described at URLhttps://www.theatlantic.com/health/archive/2022/09/mecfs-chronic-fatigue-syndrome-doctors-long-covid/671518/?utm_source=pocket-newtab-global-en-GB, https://www.cdc.gov/me-cfs/causes/index.html, https://www.cdc.gov/me-cfs/es/causes/lo-que-causa-em-sfc.html Edit
ICD-9-CM780.71, 780.79 Edit
ICPC 2 IDA04 Edit

Myalgic encephalomyelitis​/​chronic fatigue syndrome (ME/CFS) be a disabling chronic illness. People plus ME/CFS dey experience profound fatigue wey no dey go away with rest, as well as sleep issues den problems plus memory anaa concentration. De hallmark symptom be post-exertional malaise (PEM), a worsening of de illness wey fi start immediately anaa hours to days after even minor physical anaa mental activity. Dis "crash" fi last from hours anaa days to several months. Further common symptoms dey include dizziness anaa faintness wen upright den pain.[1][2]

De cause of de disease be unknown.[3] ME/CFS often dey start after an infection, such as mononucleosis[4] wey e fi run insyd families.[5] ME/CFS dey associate plus changes insyd de nervous den immune systems, as well as insyd energy production.[6] Diagnosis dey base on distinctive symptoms, den a differential diagnosis, secof no diagnostic test such as a blood test anaa imaging be available.[7][8]

Symptoms of ME/CFS sam times fi be treated wey de illness fi improve anaa worsen over time, buh a full recovery be uncommon.[4][9] Dem no approve therapies anaa medications to treat de condition, wey de management be aimed at relieving symptoms.[10]: 29  Pacing of activities fi help avoid worsening symptoms, den counselling fi help in coping plus de illness. Before de COVID-19 pandemic, na ME/CFS affect two to nine out of every 1,000 people, wey dey depend on de definition.[11] However, chaw people dey fit ME/CFS diagnostic criteria after dem develop long COVID.[12] ME/CFS dey occur more often insyd women dan insyd men. E be more common insyd middle age, buh fi occur at all ages, wey dey include kiddie time.[13]

ME/CFS get a large social den economic impact, wey de disease fi be socially isolating.[14] About a quarter of those wey be affected be unable to leave dema bed anaa home.[15]: 3  People plus ME/CFS often dey face stigma insyd healthcare settings, wey care be complicated by controversies around de cause den treatments of de illness.[16] Doctors fi be unfamiliar plus ME/CFS, as e often no be fully covered insyd medical school.[13] Historically, na research funding give ME/CFS be far below dat of diseases plus comparable impact.[17]

References

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  1. ↑ "Symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". U.S. Centers for Disease Control and Prevention (CDC). 10 May 2024. Archived from the original on 17 May 2024. Retrieved 17 May 2024.
  2. ↑ Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG) (17 April 2023). Myalgische Enzephalomyelitis / Chronic Fatigue Syndrome (ME/CFS): Aktueller Kenntnisstand [Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): current state of knowledge] (PDF) (in German). Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen. ISSN 1864-2500. Archived (PDF) from the original on 2 November 2023. Retrieved 8 November 2023.
  3. ↑ "Clinical Overview of ME/CFS". U.S. Centers for Disease Control and Prevention (CDC). 10 May 2024. Archived from the original on 17 May 2024. Retrieved 17 May 2024.
  4. 1 2 Bateman L, Bested AC, Bonilla HF, Chheda BV, Chu L, Curtin JM, Dempsey TT, Dimmock ME, Dowell TG, Felsenstein D, Kaufman DL, Klimas NG, Komaroff AL, Lapp CW, Levine SM, Montoya JG, Natelson BH, Peterson DL, Podell RN, Rey IR, Ruhoy IS, Vera-Nunez MA, Yellman BP (November 2021). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Essentials of Diagnosis and Management". Mayo Clinic Proceedings. 96 (11): 2861–2878. doi:10.1016/j.mayocp.2021.07.004. PMID 34454716. S2CID 237419583.
  5. ↑ Dibble JJ, McGrath SJ, Ponting CP (September 2020). "Genetic Risk Factors of ME/CFS: A Critical Review". Human Molecular Genetics. 29 (R1): R117 – R124. doi:10.1093/hmg/ddaa169. PMC 7530519. PMID 32744306.
  6. ↑ Annesley SJ, Missailidis D, Heng B, Josev EK, Armstrong CW (March 2024). "Unravelling Shared Mechanisms: Insights from Recent ME/CFS Research to Illuminate Long COVID Pathologies". Trends in Molecular Medicine. 30 (5): 443–458. doi:10.1016/j.molmed.2024.02.003. PMID 38443223.
  7. ↑ Maksoud R, Magawa C, Eaton-Fitch N, Thapaliya K, Marshall-Gradisnik S (May 2023). "Biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review". BMC Medicine. 21 (1) 189. doi:10.1186/s12916-023-02893-9. PMC 10206551. PMID 37226227.
  8. ↑ "Myalgic encephalomyelitis (Chronic fatigue syndrome) - Symptoms, diagnosis and treatment | BMJ Best Practice US". bestpractice.bmj.com (in American English). Retrieved 2024-10-21.
  9. ↑ CDC (2024-05-22). "Manage Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (in American English). Retrieved 2025-04-08.
  10. ↑ "Myalgic Encephalomyelitis (Or Encephalopathy)/Chronic Fatigue Syndrome: Diagnosis and Management: NICE Guideline". www.nice.org.uk. 29 October 2021. Archived from the original on 8 February 2024. Retrieved 6 December 2025.
  11. ↑ Lim EJ, Ahn YC, Jang ES, Lee SW, Lee SH, Son CG (February 2020). "Systematic Review and Meta-Analysis Of the Prevalence of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)". Journal of Translational Medicine. 18 (1) 100. doi:10.1186/s12967-020-02269-0. PMC 7038594. PMID 32093722.
  12. ↑ Davis HE, McCorkell L, Vogel JM, Topol EJ (March 2023). "Long COVID: Major Findings, Mechanisms and Recommendations". Nature Reviews. Microbiology. 21 (3): 133–146. doi:10.1038/s41579-022-00846-2. PMC 9839201. PMID 36639608.
  13. 1 2 "ME/CFS Basics" (in American English). U.S. Centers for Disease Control and Prevention (CDC). 10 May 2024. Archived from the original on 23 May 2024. Retrieved 25 May 2024.
  14. ↑ Boulazreg, S, Rokach A (17 July 2020). "The Lonely, Isolating, and Alienating Implications of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Healthcare (in English). 8 (4): 413–433. doi:10.3390/healthcare8040413. ISSN 2164-1846. PMC 7711762. PMID 33092097.
  15. ↑ Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG) (17 April 2023). Myalgische Enzephalomyelitis / Chronic Fatigue Syndrome (ME/CFS): Aktueller Kenntnisstand [Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): current state of knowledge] (PDF) (in German). Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen. ISSN 1864-2500. Archived (PDF) from the original on 2 November 2023. Retrieved 8 November 2023.
  16. ↑ Hussein, Said; Eiriksson, Lauren; MacQuarrie, Maureen; Merriam, Scot; Dalton, Maria; Stein, Eleanor; Twomey, Rosie (2024). "Healthcare System Barriers Impacting the Care of Canadians with Myalgic Encephalomyelitis: A Scoping Review". Journal of Evaluation in Clinical Practice (in English). 30 (7): 1337–1360. doi:10.1111/jep.14047. ISSN 1356-1294. PMID 39031904.
  17. ↑ Tyson S, Stanley K, Gronlund TA, Leary S, Emmans Dean M, Dransfield C, Baxter H, Elliot R, Ephgrave R, Bolton M, Barclay A, Hoyes G, Marsh B, Fleming R, Crawford J (2022). "Research Priorities for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): The Results of a James Lind Alliance Priority Setting Exercise". Fatigue: Biomedicine, Health & Behavior (in English). 10 (4): 200–211. doi:10.1080/21641846.2022.2124775. ISSN 2164-1846. S2CID 252652429.
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