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Myelodysplastic syndrome

From Wikipedia
myelodysplastic syndrome
class of disease
Subclass ofmyeloproliferative disorders, neoplastic syndrome, disease Edit
Has effectineffective erythropoiesis Edit
Health specialtyhematology Edit
Genetic associationASXL1, SETBP1, TET2, GATA2, DNMT3A Edit
ICD-9-CM238.75, 238.7 Edit
NCI Thesaurus IDC3247 Edit

A myelodysplastic syndrome (MDS) be one of a group of cancers insyd wich blood cells insyd de bone marrow no dey mature, den as a result, no dey develop into healthy blood cells.[1] Early on, dem no dey see symptoms typically.[1] Later, symptoms fi include fatigue, shortness of breath, bleeding disorders, anemia, anaa frequent infections.[1] Sam types fi develop into acute myeloid leukemia.[1]

Risk factors dey include previous chemotherapy anaa radiation therapy, exposure to certain chemicals such as tobacco smoke, pesticides, den benzene, den exposure to heavy metals such as mercury anaa lead.[1] Problems plus blood cell formation result in sam combination of low red blood cell, platelet, den white blood cell counts.[1] Sam types of MDS dey cause an increase insyd de production of immature blood cells (dem call blasts), insyd de bone marrow anaa blood.[1] De different types of MDS be identified based on de specific characteristics of de changes insyd de blood cells den bone marrow.[1]

Treatments fi include supportive care, drug therapy, den hematopoietic stem cell transplantation.[1] Supportive care fi include blood transfusions, medications to increase de making of red blood cells, den antibiotics.[1] Drug therapy fi include de medications lenalidomide, antithymocyte globulin, den azacitidine.[1] Sam people fi be cured by chemotherapy followed by a stem-cell transplant from a donor.[1]

About seven per 100,000 people be affected by MDS; about four per 100,000 people newly acquire de condition each year.[2] De typical age of onset be 70 years.[2] De prognosis dey depend on de type of cells affected, de number of blasts insyd de bone marrow anaa blood, den de changes present insyd de chromosomes of de affected cells.[1] De average survival time dey follow diagnosis be 2.5 years.[2] Na dem first recognize MDS insyd de early 1900s;[3] wey na e cam be called myelodysplastic syndrome insyd 1976.[3]

People plus MDS

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  • Michael Brecker, musician[4]
  • Laurentino Cortizo, de Presido of Panama[5]
  • Roald Dahl, writer[6]
  • Nora Ephron, journalist, writer, den filmmaker
  • Pat Hingle, actor[7]
  • Paul Motian, musician[8]
  • Amrish Puri, actor[9]
  • Carl Sagan, astrophysicist[10]
  • Susan Sontag, author[11]
  • Norm Macdonald, comedian[12]

References

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  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 "Myelodysplastic Syndromes Treatment (PDQ®) – Patient Version". NCI. 12 August 2015. Archived from the original on 5 October 2016. Retrieved 27 October 2016.
  2. 1 2 3 Germing U, Kobbe G, Haas R, Gattermann N (November 2013). "Myelodysplastic syndromes: diagnosis, prognosis, and treatment". Deutsches Ärzteblatt International. 110 (46): 783–90. doi:10.3238/arztebl.2013.0783. PMC 3855821. PMID 24300826.
  3. 1 2 Hong, Waun Ki; Holland, James F. (2010). Holland-Frei Cancer Medicine (8th ed.). PMPH-USA. p. 1544. ISBN 978-1-60795-014-1. Archived from the original on 2016-10-27.
  4. ↑ "Saxophonist Brecker dies from MDS". Variety. 14 January 2007. Retrieved 23 September 2018.
  5. ↑ "Panama says President Cortizo still in remission from rare blood disorder". Reuters. 2023-12-06. Retrieved 2023-12-06.
  6. ↑ "Deaths England and Wales 1984–2006". Findmypast.com. Archived from the original on 28 February 2009. Retrieved 28 January 2011.
  7. ↑ Staff, JournalNow (4 January 2009). "Veteran actor Pat Hingle dies at 84 in NC home". Winston-Salem Journal.
  8. ↑ McClellan, Dennis (November 24, 2011). "Paul Motian dies at 80; jazz drummer and composer". Los Angeles Times. Archived from the original on April 14, 2016. Retrieved 22 February 2020.
  9. ↑ "The Tribune, Chandigarh, India – Main News". Tribuneindia.com. Archived from the original on 11 December 2008. Retrieved 21 June 2019.
  10. ↑ "Remembering Carl Sagan". Universe Today. 9 November 2012. Archived from the original on 12 March 2017. Retrieved 10 March 2017.
  11. ↑ "Illness as More Than Metaphor". The New York Times Magazine. 4 December 2005. Retrieved 18 December 2017.
  12. ↑ Edgers, Geoff (2022-05-29). "Norm Macdonald had one last secret". The Washington Post (in American English). Retrieved 2025-05-19.
[edit | edit source]
  • Fenaux P, Haase D, Sanz GF, Santini V, Buske C (September 2014). "Myelodysplastic syndromes: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up". Ann Oncol. 25 (Suppl 3): III57 – III69. doi:10.1093/annonc/mdu180. hdl:2158/1078046. PMID 25185242.
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