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Naproxen

From Wikipedia
naproxen
type of chemical entity
Subclass ofnon-steroidal anti-inflammatory drug Edit
Get useMedication Edit
Tym dem start1976 Edit
Stereoisomer of(-)-naproxen Edit
Chemical formulaC₁₄H₁₄O₃ Edit
Canonical SMILESCC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O Edit
Isomeric SMILESC[C@@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O Edit
World Health Organisation international non-proprietary namenaproxen Edit
Found insyd taxonMusa cavendishii, Plantago major Edit
Physically dey interact plusProstaglandin-endoperoxide synthase 1, Prostaglandin-endoperoxide synthase 2, Prostaglandin-endoperoxide synthase 1, Prostaglandin-endoperoxide synthase 2 Edit
Legal status (medicine)boxed warning Edit
Pregnancy categoryAustralian pregnancy category C, US pregnancy category C Edit
Subject has rolecyclooxygenase inhibitors, non-steroidal anti-inflammatory drug, antigout agent Edit
MCN code2918.99.40 Edit

Naproxen, dem sell under de brand name Aleve among odas, be a nonsteroidal anti-inflammatory drug (NSAID) dem use to treat pain, menstrual cramps, den inflammatory diseases such as rheumatoid arthritis, gout den fever.[1] Dem dey take am orally.[1] E be available insyd immediate den delayed release formulations.[1] Onset of effects be within an hour den dey last for up to twelve hours.[1] Naproxen sanso be available insyd salt form, naproxen sodium, wich get better solubility wen dem take am orally.[2]

Common side effects dey include dizziness, headache, bruising, allergic reactions, heartburn, den stomach pain.[1] Severe side effects dey include an increased risk of heart disease, stroke, gastrointestinal bleeding, den stomach ulcers.[1] De heart disease risk fi be lower dan plus oda NSAIDs.[1] E no be recommended insyd people plus kidney problems.[1] Ein use no be recommended insyd de third trimester of pregnancy.[1]

Naproxen br a nonselective COX inhibitor.[1] As an NSAID, naproxen dey appear to exert ein anti-inflammatory action by reducing de production of inflammatory mediators dem call prostaglandins.[3] E be metabolized by de liver to inactive metabolites.[1]

Na dem patent naproxen insyd 1967 wey na dem approve am for medical use insyd de United States insyd 1976.[1][4][5] Insyd de United States e be available over-the-counter den as a generic medication.[1][6] Insyd 2023, na e be de 103rd most commonly prescribed medication insyd de United States, plus more dan 6 million prescriptions.[7][8] Naproxen be a therapeutic alternative on de World Health Organization's List of Essential Medicines.[9]

References

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  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 "Naproxen Monograph for Professionals". Drugs.com. AHFS. Retrieved 19 December 2018.
  2. ↑ Derry C, Derry S, Moore RA, McQuay HJ (January 2009). "Single dose oral naproxen and naproxen sodium for acute postoperative pain in adults". The Cochrane Database of Systematic Reviews. 2009 (1) CD004234. doi:10.1002/14651858.CD004234.pub3. PMC 6483469. PMID 19160232.
  3. ↑ McEvoy GK (2000). AHFS Drug Information, 2000. American Society of Health-System Pharmacists. p. 1854. ISBN 978-1-58528-004-9.
  4. ↑ "Naprosyn- naproxen tablet EC-Naprosyn- naproxen tablet, delayed release Anaprox DS- naproxen sodium tablet". DailyMed. 1 July 2019. Retrieved 27 December 2019.
  5. ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 520. ISBN 978-3-527-60749-5.
  6. ↑ "Medicines A to Z - Naproxen". NHS. National Health Service. 24 October 2018. Retrieved 11 March 2020.
  7. ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  8. ↑ "Naproxen Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved 18 August 2025.
  9. ↑ World Health Organization (2025). The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines, 24th list. Geneva: World Health Organization. hdl:10665/382243.
[edit | edit source]
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