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Omeprazole

From Wikipedia
omeprazole
type of chemical entity
Subclass ofproton-pump inhibitor, heterocyclic compound Edit
Get useMedication Edit
Stylized namePriLOSEC Edit
Chemical formulaC₁₇H₁₉N₃O₃S Edit
Canonical SMILESCC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC Edit
Active ingredient inPrilosec, Omesec Edit
Physically dey interact plusATPase H+/K+ transporting subunit alpha, chloride voltage-gated channel 2 Edit
Legal status (medicine)General sales list (UK), boxed warning Edit
Pregnancy categoryAustralian pregnancy category B3, US pregnancy category C Edit
LiverTox likelihood scoreLiverTox toxicity likelihood category B Edit
Get characteristicbitterness Edit
Subject has roleproton-pump inhibitor, anti-ulcer drug, essential medicine Edit
MCN code2933.39.46 Edit

Omeprazole, dem sell under de brand names Prilosec den Losec among odas, be a medication dem use insyd de treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease, den Zollinger–Ellison syndrome.[1] Dem sanso dey use am to prevent upper gastrointestinal bleeding insyd people wey be at high risk.[1] Omeprazole be a proton-pump inhibitor (PPI) den ein effectiveness be similar to dat of oda PPIs.[2] Dem fi take am by mouth anaa by injection into a vein.[1][3] E sanso be available insyd de fixed-dose combination medication omeprazole/sodium bicarbonate as Zegerid[4][5] den as Konvomep.[6]

Common side effects dey include nausea, vomiting, headaches, abdominal pain, den increased intestinal gas.[1][7] Serious side effects fi include Clostridioides difficile colitis, an increased risk of pneumonia, an increased risk of bone fractures, den de potential of masking stomach cancer.[1] Whether e be safe for use insyd pregnancy be unclear.[1] E dey work by blocking de release of stomach acid.[1]

Na dem patent omeprazole insyd 1978 wey na dem approve am for medical use insyd 1988.[8][9][10] E dey on de World Health Organization's List of Essential Medicines.[11] E be available as a generic medication.[1] Insyd 2023, na e be de tenth most commonly prescribed medication insyd de United States, plus more dan 45 million prescriptions.[12][13] E sanso be available widout a prescription insyd de United States.[14][15]

References

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  1. 1 2 3 4 5 6 7 8 "Omeprazole". The American Society of Health-System Pharmacists. Archived from the original on 19 February 2011. Retrieved 21 October 2018.
  2. ↑ "[99] Comparative effectiveness of proton pump inhibitors | Therapeutics Initiative". 28 June 2016. Archived from the original on 30 October 2020. Retrieved 14 July 2016.
  3. ↑ "Omeprazole 40 mg Powder for Solution for Infusion". EMC. 10 February 2016. Archived from the original on 7 April 2016. Retrieved 21 October 2018.
  4. ↑ "Zegerid- omeprazole and sodium bicarbonate powder, for suspension Zegerid- omeprazole and sodium bicarbonate capsule". DailyMed. 4 March 2022. Retrieved 16 December 2022.
  5. ↑ "Zegerid OTC- omeprazole and sodium bicarbonate capsule, gelatin coated". DailyMed. 5 December 2022. Retrieved 16 December 2022.
  6. ↑ "Konvomep- omeprazole and sodium bicarbonate kit". DailyMed. 30 August 2022. Retrieved 21 January 2023.
  7. ↑ Vallerand AH, Sanoski CA, Deglin JH (2015). Davis's Drug Guide for Nurses (14th ed.). F.A. Davis Company. pp. 924–925. ISBN 978-0-8036-4085-6. OCLC 881473728.
  8. ↑ Lagercrantz, Samuel (29 November 2022). "The stomach medication that became the biggest blockbuster of the 1990s". Life Science Sweden. Retrieved 9 July 2025.
  9. ↑ "Product Details for NDA 019810". U.S. Food and Drug Administration (FDA). 5 October 1995. Retrieved 9 July 2025.
  10. ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 445. ISBN 9783527607495. Archived from the original on 3 August 2020. Retrieved 29 June 2020.
  11. ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  12. ↑ "The Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  13. ↑ "Omeprazole Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 12 August 2025.
  14. ↑ "Questions and Answers on Prilosec OTC (omeprazole)". U.S. Food and Drug Administration (FDA). 3 November 2018. Archived from the original on 28 August 2021. Retrieved 2 March 2020.
  15. ↑ "Drug Approval Package: Prilosec (Omeprazole Magnesium) NDA #021229". U.S. Food and Drug Administration (FDA). Archived from the original on 24 January 2022. Retrieved 6 October 2022.

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