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Ondansetron

From Wikipedia
ondansetron
group of stereoisomers
Subclass ofessential medicine, indoles, imidazole, cyclic ketone Edit
Chemical formulaC₁₈H₁₉N₃O Edit
Canonical SMILESCC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C Edit
Active ingredient inZofran, Zuplenz, Vonau Flash Edit
World Health Organisation international non-proprietary nameondansetron Edit
Medical condition treatedalcohol abuse, gastroenteritis Edit
Physically dey interact plus5-hydroxytryptamine receptor 3A Edit
Pregnancy categoryAustralian pregnancy category B1, US pregnancy category B Edit
ManufacturerPfizer Edit
Subject has roleantipsychotics, serotonin antagonist, antiemetic, anxiolytic, antipruritic Edit

Ondansetron, dem sell under de brand name Zofran among odas, be a medication dem use to prevent nausea den vomiting wey be caused by chemotherapy, radiation therapy, migraines, anaa surgery.[1] E sanso be effective for treating gastroenteritis.[2][3] Dem fi give am orally (by mouth), intramuscularly (injection into a muscle), anaa intravenously (injection into a vein).[1]

Common side effects dey include diarrhea, constipation, headache, sleepiness, den itchiness.[1] Serious side effects dey include QT prolongation den severe allergic reaction.[1] E dey appear to be safe during pregnancy buh e no be well studied insyd dis group.[1] E be a serotonin 5-HT3 receptor antagonist.[1] E no dey get any effect on dopamine receptors anaa muscarinic acetylcholine receptor den therefore no dey cause akathisia.[4]

Na dem patent ondansetron insyd 1984 wey na dem approve am for medical use insyd 1990.[5] E dey on de World Health Organization's List of Essential Medicines.[6] E be available as a generic medication.[1] Insyd 2023, na e be de 53rd most commonly prescribed medication insyd de United States, plus more dan 12 million prescriptions.[7][8]

References

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  1. 1 2 3 4 5 6 7 "Ondansetron Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 3 May 2016. Retrieved 11 February 2017.
  2. ↑ Schnadower D, Finkelstein Y, Freedman SB (January 2015). "Ondansetron and probiotics in the management of pediatric acute gastroenteritis in developed countries". Current Opinion in Gastroenterology. 31 (1): 1–6. doi:10.1097/mog.0000000000000132. PMID 25333367. S2CID 9334264.
  3. ↑ Freedman SB, Ali S, Oleszczuk M, Gouin S, Hartling L (July 2013). "Treatment of acute gastroenteritis in children: an overview of systematic reviews of interventions commonly used in developed countries". Evidence-Based Child Health. 8 (4): 1123–37. doi:10.1002/ebch.1932. PMID 23877938.
  4. ↑ Miloro M, ed. (2012). Peterson's principles of oral and maxillofacial surgery (3rd ed.). Shelton, CT: People's Medical Pub. House-USA. p. 86. ISBN 978-1-60795-111-7. Archived from the original on 1 February 2016.
  5. ↑ FischerJ, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 448. ISBN 978-3-527-60749-5. Archived from the original on 12 January 2023. Retrieved 25 August 2020.
  6. ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  7. ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  8. ↑ "Ondansetron Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved 18 August 2025.
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Dem retrieve am from "https://gpe.wikipedia.org/w/index.php?title=Ondansetron&oldid=83209"