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Osteoporosis

From Wikipedia
osteoporosis
class of disease
Subclass ofbone resorption disease, disease Edit
Facet givewomen's health Edit
Health specialtyrheumatology Edit
Drug or therapy used for treatmentcholecalciferol, bisphosphonate Edit
WordLift URLhttp://data.medicalrecords.com/medicalrecords/healthwise/osteoporosis Edit
ICD-9-CM733.0, 733.00, 733.09 Edit
ICPC 2 IDL95 Edit

Osteoporosis be a systemic skeletal disorder wey be characterized by low bone mass, micro-architectural deterioration of bone tissue wey dey lead to more porous bone, den consequent increase insyd fracture risk. Bones dey undergo continuous remodeling: osteoclasts resorb old bone, den osteoblasts synthesize new bone. Plus advancing age, de rate of resorption dey exceed dat of bone formation, wey dey cause bones to lose density den cam be more susceptible to fractures.[1] De word "osteoporosis" be from de Greek terms for "porous bones".[2]

Osteoporosis be de most common reason for a broken bone among de elderly.[3] Bones wey dey commonly break dey include de vertebrae insyd de spine, de bones of de forearm, de wrist, den de hip.[4][5] Til a broken bone occur, der be typically no symptoms. Bones fi weaken to such a degree dat a break fi occur plus minor stress anaa spontaneously. After de broken bone heal, sam people fi get chronic pain den a decreased ability to carry out normal activities.[3]

Osteoporosis fi be secof lower-than-normal maximum bone mass den greater-than-normal bone loss. Bone loss dey increase after menopause insyd women secof lower levels of estrogen,[6] den after insyd older men secof lower levels of testosterone.[7] Osteoporosis sanso fi occur secof several diseases anaa treatments, wey dey include alcoholism, anorexia, hyperthyroidism, kidney disease, den after oophorectomy (surgical removal of de ovaries). Certain medications dey increase de rate of bone loss, wey dey include chemotherapy, glucocorticosteroids. Smoking den a sedentary lifestyle sanso be recognized as major risk factors.[3] Osteoporosis be defined as a bone density of 2.5 standard deviations below dat of a young adult. Dis typically be measured by a DXA (anaa DEXA) bone density scan.[8]

Prevention of osteoporosis dey include a proper diet during kiddie time, hormone replacement therapy for menopausal women, den efforts to avoid medications wey increase de rate of bone loss. Efforts to prevent broken bones insyd those plus osteoporosis dey include a good diet, exercise, den fall prevention. Lifestyle changes such as stopping smoking den no dey drink alcohol fi help.[3] Bisphosphonate medications be useful to decrease future broken bones insyd those plus previous broken bones secof osteoporosis. Insyd those plus osteoporosis buh no previous broken bones, dem show to be less effective.[9][10][11] Dem no dey appear to affect de risk of death.[12]

Osteoporosis cam be more common plus age. About 15% of Caucasians insyd dema 50s den 70% of those over 80 be affected.[13] E be more common insyd women dan men.[3] Insyd de developed world, dey depend on de method of diagnosis, 2% to 8% of males den 9% to 38% of females be affected.[14] Rates of disease insyd de developing world be unclear.[15] White den Asian people be at greater risk for low bone mineral density secof dema lower serum vitamin D levels den less vitamin D synthesis at certain latitudes.[3]

References

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  1. "Osteoblasts and Osteoclasts". Cleveland Clinic. 27 March 2023. Retrieved 5 May 2026.{{cite web}}: CS1 maint: url-status (link)
  2. Grob, Gerald N. (2014). Aging Bones: A Short History of Osteoporosis. JHU Press. p. 5. ISBN 978-1-4214-1318-1.
  3. 1 2 3 4 5 6 "Handout on Health: Osteoporosis". NIAMS. August 2014. Archived from the original on 18 May 2015. Retrieved 16 May 2015.
  4. Golob AL, Laya MB (May 2015). "Osteoporosis: screening, prevention, and management". The Medical Clinics of North America. 99 (3): 587–606. doi:10.1016/j.mcna.2015.01.010. PMID 25841602.
  5. NIAMS Science Communications and Outreach Branch (2017-04-07). "Osteoporosis". National Institute of Arthritis and Musculoskeletal and Skin Diseases (in English). Retrieved 2023-09-16.
  6. "Menopause and Bone Loss". www.endocrine.org (in English). 2022-01-24. Retrieved 2025-10-04.
  7. Monaco, Kristen (2018-06-04). "Clinical Challenges: Managing Osteoporosis in Male Hypogonadism". MedPage Today (in English). Ziff Davis. Retrieved 2022-03-22.
  8. Prevention and management of osteoporosis. World Health Organization Technical Report Series. Vol. 921. World Health Organization. 2003. pp. 1–164, back cover. hdl:10665/42841. ISBN 978-92-4-120921-2. PMID 15293701.
  9. Wells GA, Cranney A, Peterson J, Boucher M, Shea B, Robinson V, Coyle D, Tugwell P (January 2008). "Alendronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women". The Cochrane Database of Systematic Reviews (1) CD001155. doi:10.1002/14651858.CD001155.pub2. PMID 18253985.
  10. Wells GA, Hsieh SC, Zheng C, Peterson J, Tugwell P, Liu W (May 2022). "Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women". The Cochrane Database of Systematic Reviews. 2022 (7) CD004523. doi:10.1002/14651858.CD004523.pub4. PMC 9062986. PMID 35502787.
  11. Wells, George A.; Hsieh, Shu-Ching; Peterson, Joan; Zheng, Carine; Kelly, Shannon E.; Shea, Beverley; Tugwell, Peter (2024-04-09). "Etidronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women". The Cochrane Database of Systematic Reviews. 2024 (4) CD003376. doi:10.1002/14651858.CD003376.pub4. ISSN 1469-493X. PMC 11003221. PMID 38591743.
  12. Cummings SR, Lui LY, Eastell R, Allen IE (August 2019). "Association Between Drug Treatments for Patients With Osteoporosis and Overall Mortality Rates: A Meta-analysis". JAMA Internal Medicine. 179 (11): 1491–1500. doi:10.1001/jamainternmed.2019.2779. PMC 6704731. PMID 31424486.
  13. "Chronic rheumatic conditions". World Health Organization. Archived from the original on 27 April 2015. Retrieved 18 May 2015.
  14. Wade SW, Strader C, Fitzpatrick LA, Anthony MS, O'Malley CD (2014). "Estimating prevalence of osteoporosis: examples from industrialized countries". Archives of Osteoporosis. 9 (1) 182. doi:10.1007/s11657-014-0182-3. PMID 24847682. S2CID 19534928.
  15. Handa R, Ali Kalla A, Maalouf G (August 2008). "Osteoporosis in developing countries". Best Practice & Research. Clinical Rheumatology. 22 (4): 693–708. doi:10.1016/j.berh.2008.04.002. PMID 18783745.
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