Oxytocin
| Subclass of | biogenic cyclopeptide |
|---|---|
| Part of | oxytocin receptor activity, oxytocin production, Oxytocin/neurophysin I prepropeptide |
| Facet give | women's health |
| Chemical formula | C₄₃H₆₆N₁₂O₁₂S₂ |
| Canonical SMILES | CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N |
| Isomeric SMILES | CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N |
| Active ingredient in | Pitocin, Oxytocin |
| World Health Organisation international non-proprietary name | oxytocin |
| Found insyd taxon | Oxystelma esculentum, Oxystelma wallichii |
| Dem encode by | OXT |
| Physically dey interact plus | oxytocin receptor, Arginine vasopressin receptor 1A, Arginine vasopressin receptor 1B, Arginine vasopressin receptor 2 |
| Legal status (medicine) | boxed warning |
| Pregnancy category | Australian pregnancy category A |
| Get characteristic | biopharmaceutical |
| Subject has role | oxytocics, essential medicine, hormone |
| Used by | biological basis of love |
| WordLift URL | http://data.medicalrecords.com/medicalrecords/healthwise/oxytocin |
| MCN code | 3004.39.22, 2937.19.50, 3003.39.22 |
Oxytocin be a peptide hormone den neuropeptide dem normally produce insyd de hypothalamus wey e be released by de posterior pituitary.[1] Present insyd animals since early stages of evolution, insyd humans e dey play roles insyd behavior wey dey include social bonding, love, reproduction, childbirth, den de period after childbirth.[2][3][4][5] Oxytocin be released into de bloodstream as a hormone in response to sexual activity den during childbirth.[6][7] E sanso be available insyd pharmaceutical form. Insyd either form, oxytocin dey stimulate uterine contractions to speed up de process of childbirth.
Insyd ein natural form, e sanso dey play a role in maternal bonding den milk production.[7][8] Production den secretion of oxytocin be controlled by a positive feedback mechanism, wer ein initial release dey stimulate production den release of further oxytocin. For example, wen oxytocin be released during a contraction of de uterus at de start of childbirth, dis dey stimulate production den release of more oxytocin den an increase insyd de intensity den frequency of contractions. Dis process dey compound insyd intensity den frequency den dey continue til de triggering activity ceases. A similar process dey take place during lactation den during sexual activity.
Oxytocin be derived by enzymatic wey dey split from de peptide precursor encoded by de human OXT gene. De deduced structure of de active nonapeptide be:
Cys – Tyr – Ile – Gln – Asn – Cys – Pro – Leu – Gly – NH2, or CYIQNCPLG-NH2.
References
[edit | edit source]- ↑ Gray's Anatomy: The Anatomical Basis of Clinical Practice (41 ed.). Elsevier Health Sciences. 2015. p. 358. ISBN 978-0-7020-6851-5.
- ↑ Audunsdottir K, Quintana DS (2022-01-25). "Oxytocin's dynamic role across the lifespan". Aging Brain (in English). 2 100028. doi:10.1016/j.nbas.2021.100028. ISSN 2589-9589. PMC 9997153. PMID 36908876. S2CID 246314607.
- ↑ Leng G, Leng RI (November 2021). "Oxytocin: A citation network analysis of 10 000 papers". Journal of Neuroendocrinology. 33 (11) e13014. doi:10.1111/jne.13014. hdl:20.500.11820/d2bdf31e-1d12-4abf-80a3-659a7e31a9f7. PMID 34328668. S2CID 236516186.
- ↑ Francis DD, Young LJ, Meaney MJ, Insel TR (May 2002). "Naturally occurring differences in maternal care are associated with the expression of oxytocin and vasopressin (V1a) receptors: gender differences". Journal of Neuroendocrinology. 14 (5): 349–53. doi:10.1046/j.0007-1331.2002.00776.x. PMID 12000539. S2CID 16005801.
- ↑ Gainer H, Fields RL, House SB (October 2001). "Vasopressin gene expression: experimental models and strategies". Experimental Neurology. 171 (2): 190–9. doi:10.1006/exnr.2001.7769. PMID 11573971. S2CID 25718623.
- ↑ Rogers K (7 July 2023). "Oxytocin". Encyclopædia Britannica.
- 1 2 Chiras DD (2012). Human Biology (7th ed.). Sudbury, MA: Jones & Bartlett Learning. p. 262. ISBN 978-0-7637-8345-7.
- ↑ Human Evolutionary Biology. Cambridge University Press. 2010. p. 282. ISBN 978-1-139-78900-4.
Read further
[edit | edit source]- Caldwell HK, Young WS (2006). "Oxytocin and Vasopressin: Genetics and Behavioral Implications" (PDF). In Abel L, Lim R (eds.). Handbook of neurochemistry and molecular neurobiology. Berlin: Springer. pp. 573–607. ISBN 978-0-387-30348-2. Archived from the original (PDF) on 2011-05-04. Retrieved 2006-05-24.
- Schmitz S, Höppner G, eds. (2014). "Oxytocin as proximal cause of 'maternal instinct': weak science, post-feminism, and the hormones of mystique". Gendered neurocultures: feminist and queer perspectives on current brain discourses. challenge GENDER, 2. Wien: Zaglossus. ISBN 978-3-902902-12-2.
- Yong E (13 November 2015). "The weak science behind the wrongly named moral molecule". The Atlantic..
External links
[edit | edit source]- CS1 English-language sources (en)
- Commons category link from Wikidata
- Analgesics
- Antidiuretics
- Breastfeeding
- Gynaecological endocrinology
- Hormones of de hypothalamus
- Hormones of de pregnant female
- Human female endocrine system
- Interpersonal attraction
- Neuropeptides
- Neurotransmitters
- Opioid receptor positive allosteric modulators
- Orgasm
- Oxytocin receptor agonists
- Posterior pituitary hormones
- Vasopressin receptor agonists
- Orphan drugs
- Nonapeptides
- Happy hormones
- Translated from MDWiki