Pantoprazole
| Subclass of | chemical compound  |
|---|---|
| Get use | Medication |
| Chemical formula | C₁₆H₁₅F₂N₃O₄S |
| Canonical SMILES | COC1=C(C(=NC=C1)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC(F)F)OC |
| World Health Organisation international non-proprietary name | pantoprazole |
| Legal status (medicine) | boxed warning |
| Pregnancy category | Australian pregnancy category B3, US pregnancy category B |
| LiverTox likelihood score | LiverTox toxicity likelihood category C |
| Get characteristic | bitterness |
| Subject has role | proton-pump inhibitor, anti-ulcer drug |
Pantoprazole, dem sell under de brand name Protonix, among odas, be a medication dem use for de treatment of stomach ulcers, short-term treatment of erosive esophagitis secof gastroesophageal reflux disease (GERD), maintenance of healing of erosive esophagitis, den pathological hypersecretory conditions wey dey include Zollinger–Ellison syndrome.[1][2] E sanso fi be used along plus oda medications to eliminate Helicobacter pylori.[3] Pantoprazole be a proton-pump inhibitor (PPI) wey ein effectiveness be similar to dat of oda PPIs.[4] E be available by mouth den by injection into a vein.[1]
Common side effects dey include headaches, diarrhea, abdominal pain, den joint pain.[1][2] More serious side effects fi include severe allergic reactions, a type of chronic inflammation dem know as atrophic gastritis, Clostridioides difficile colitis, low magnesium, den vitamin B12 deficiency.[1] Ein use insyd pregnancy dey appear to be safe.[1] Pantoprazole be a proton pump inhibitor wey dey decrease gastric acid secretion.[1] E dey work by inactivating (H+/K+)-ATPase function insyd de stomach.[1][5]
Na de study of pantoprazole begin insyd 1985, wey na e cam into medical use insyd Germany insyd 1994.[6] E be available as a generic medication.[1][7] Insyd 2023, na e be de thirteenth most commonly prescribed medication insyd de United States, plus more dan 37 million prescriptions.[8][9] Insyd Australia, na e be one of de top 10 most prescribed medications between 2017 den 2023.[10]
References
[edit | edit source]- 1 2 3 4 5 6 7 8 "Pantoprazole Sodium Monograph for Professionals - Drugs.com". Drugs.com. American Society of Health-System Pharmacists. Retrieved 28 October 2018.
- 1 2 Bernshteyn MA, Masood U (2022). "Pantoprazole". StatPearls. Treasure Island (FL): StatPearls Publishing. PMID 29763120. Retrieved 27 April 2022.
- ↑ British national formulary: BNF 74 (74 ed.). British Medical Association. 2017. p. 79. ISBN 978-0-85711-298-9.
- ↑ "[99] Comparative effectiveness of proton pump inhibitors". Therapeutics Initiative. 28 June 2016. Retrieved 14 July 2016.
- ↑ Richardson P, Hawkey CJ, Stack WA (September 1998). "Proton pump inhibitors. Pharmacology and rationale for use in gastrointestinal disorders". Drugs. 56 (3): 307–335. doi:10.2165/00003495-199856030-00002. PMID 9777309. S2CID 46962618.
- ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 130. ISBN 978-3-527-60749-5.
- ↑ "Pantoprazole: FDA-Approved Drugs". U.S. Food and Drug Administration. Archived from the original on 30 April 2017. Retrieved 15 August 2020.
- ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
- ↑ "Pantoprazole Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 12 August 2025.
- ↑ "Medicines in the health system". Australian Institute of Health and Welfare. 2 July 2024. Retrieved 30 September 2024.
External links
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