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Paroxetine

From Wikipedia
paroxetine
type of chemical entity
Subclass ofheterocyclic compound Edit
Get useMedication Edit
Stylized namePARoxetine Edit
Chemical formulaC₁₉H₂₀FNO₃ Edit
Canonical SMILESC1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4 Edit
Isomeric SMILESC1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4 Edit
Active ingredient inPaxil, Pexeva, Brisdelle Edit
World Health Organisation international non-proprietary nameparoxetine Edit
Physically dey interact plussolute carrier family 6 member 4 Edit
Route of administrationoral administration Edit
Legal status (medicine)boxed warning Edit
Pregnancy categoryAustralian pregnancy category D, US pregnancy category D Edit
Described at URLhttps://cpe.org.uk/our-news/mhra-class-2-medicines-recall-paroxetine-40mg-film-coated-tablets-crescent-pharma-limited/ Edit
Subject has roleselective serotonin reuptake inhibitor, cytochrome P-450 CYP2D6 inhibitors, second-generation antidepressive agents Edit

Paroxetine, dem sell under de brand name Paxil among odas, be an antidepressant medication of de selective serotonin reuptake inhibitor (SSRI) class[1] dem use to treat major depressive disorder, obsessive–compulsive disorder (OCD), panic disorder, social anxiety disorder, post-traumatic stress disorder (PTSD), generalized anxiety disorder, den premenstrual dysphoric disorder.[1] E sanso be used insyd de treatment of premature ejaculation,[2] den hot flashes secof menopause.[1][3] Dem dey take am orally (by mouth).[1]

Common side effects dey include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping, den sexual dysfunction.[1] Insyd sam patients, sexual dysfunction fi persist even after de drug be discontinued, a condition dem know as post-SSRI sexual dysfunction; regulatory agencies wey dey include de European Medicines Agency den Health Canada recommend say paroxetine ein product labeling warn of dis risk.[4][5] Serious side effects fi include suicidal thoughts insyd those under de age of 25, serotonin syndrome, den mania.[1]

Dem approve paroxetine for medical use insyd de United States insyd 1992 wey initially e be sold by GlaxoSmithKline.[1][6] E dey on de World Health Organization's List of Essential Medicines.[7] E be available as a generic medication.[8] Insyd 2023, na e be de 72nd most commonly prescribed medication insyd de United States, plus more dan 9 million prescriptions.[9][10] Insyd 2018, na e dey insyd de top 10 of most prescribed antidepressants insyd de United States.[11]

References

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  1. 1 2 3 4 5 6 7 "Paroxetine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
  2. ↑ Raisi F, Soleimani R, Ahmadzadeh A, Sadati SN, Fakhrian A, Jalali MM (June 2025). "Efficacy and safety of pharmacological treatments in patients with premature ejaculation: an umbrella review of meta-analyses of randomized controlled trials". The Journal of Sexual Medicine. 22 (6): 1014–1023. doi:10.1093/jsxmed/qdaf094. PMID 40326158.
  3. ↑ Fischer A (28 June 2013). "FDA approves the first non-hormonal treatment for hot flashes associated with menopause" (Press release). Food and Drug Administration. Archived from the original on 18 January 2017.
  4. ↑ Healy D, Bahrick A, Bak M, Barbato A, Calabro RS, Chubak BM (2022). "Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin". International Journal of Risk & Safety in Medicine. 33 (1): 65–76. doi:10.3233/JRS-210023. PMC 8925105. PMID 34719438.
  5. ↑ "PRAC recommendations on signals adopted at the 13-16 May 2019 PRAC meeting" (PDF). European Medicines Agency. 11 June 2019. Retrieved 8 April 2026.
  6. ↑ Food and Drug Administration (2011). Approved Drug Products with Therapeutic Equivalence Evaluations – FDA Orange Book 31st Edition (2011): FDA Orange Book 31st Edition (2011). DrugPatentWatch.com. p. 344. ISBN 978-1-934899-81-6. Archived from the original on 6 March 2019. Retrieved 4 March 2019.
  7. ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  8. ↑ British national formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 363. ISBN 978-0-85711-338-2.
  9. ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  10. ↑ "Paroxetine Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved 18 August 2025.
  11. ↑ Grohol JM (15 December 2019). "Top 25 Psychiatric Medications for 2018". psychcentral.com. Archived from the original on 25 October 2020. Retrieved 26 September 2020.
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