Permethrin
| Subclass of | pyrethroid, carbocyclic compound  |
|---|---|
| Get use | insecticide, Medication |
| Chemical formula | C₂₁H₂₀Cl₂O₃ |
| Canonical SMILES | CC1(C(C1C(=O)OCC2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Cl)Cl)C |
| Active ingredient in | Elimite, Acticin |
| World Health Organisation international non-proprietary name | permethrin |
| Medical condition treated | lice infestation, scabies, lice infestation, scabies |
| Pregnancy category | US pregnancy category B |
| Subject has role | enzyme inhibitor, WHO essential medicine |
| MCN code | 2916.20.14, 3003.90.31 |
Permethrin be a medication den an insecticide.[1][2] As a medication, e be used to treat scabies den lice.[3] E be applied to de skin as a cream anaa lotion.[1] As an insecticide, e fi be sprayed onto outer clothing anaa mosquito nets to kill de insects wey touch dem.[2][4]
Side effects dey include rash den irritation wer e be applied.[3] Use during pregnancy dey appear to be safe, wey e be approved for use on den around people over de age of two months insyd de United States.[1] Permethrin dey insyd de pyrethroid family of medications.[1] E dey work by disrupting de function of de neurons of arthropods such as lice, mites,[1] insects, den shrimp, wey dey make am highly toxic to dese animals. E sanso be highly toxic to fish.[5] E be of low toxicity to birds den mammals. However, cats be more sensitive to am dan oda mammals secof much slower metabolism.[6]
Na dem discover permethrin insyd 1972.[7] E be on de World Health Organization's List of Essential Medicines.[8] Insyd 2022, na e be de 351st most commonly prescribed medication insyd de United States, plus more dan 40,000 prescriptions.[9]
References
[edit | edit source]- 1 2 3 4 5 "Permethrin". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
- 1 2 Keystone JS, Kozarsky PE, Freedman DO, Connor BA (2013). Travel Medicine. Elsevier Health Sciences. p. 58. ISBN 978-1-4557-1076-8. Archived from the original on 20 December 2016.
- 1 2 Stuart MC, Kouimtzi M, Hill SR, eds. (2009). WHO Model Formulary 2008. World Health Organization. p. 213. hdl:10665/44053. ISBN 978-92-4-154765-9.
- ↑ "Repellent-Treated Clothing". United States Environmental Protection Agency. 15 July 2013. Retrieved 28 May 2023.
- ↑ Environmental Protection Agency (June 2006). "Permethrin Facts (Reregistration Eligibility Decision (RED) Fact Sheet)" (PDF). epa.gov. EPA Special Review and Reregistration Division. Archived (PDF) from the original on 6 August 2020. Retrieved 13 May 2020.
- ↑ "Permethrin General Fact Sheet". npic.orst.edu. Archived from the original on 3 January 2018. Retrieved 6 January 2018.
- ↑ Elliott M, Farnham AW, Janes NF, Needham PH, Pulman DA, Stevenson JH (November 1973). "A photostable pyrethroid". Nature. 246 (5429): 169–170. Bibcode:1973Natur.246..169E. doi:10.1038/246169a0. PMID 4586114. S2CID 4176154.
- ↑ The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. 2023. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
- ↑ "Permethrin Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.
External links
[edit | edit source]
- Permethrin in the Pesticide Properties DataBase (PPDB)
- Permethrin General Fact Sheet National Pesticide Information Center
- Permethrin Technical Fact Sheet National Pesticide Information Center
- Permethrin-treated Clothing National Pesticide Information Center
- "Health Effects of Permethrin-Impregnated Army Battle-Dress Uniforms" National Research Council
- Permethrin Pesticide Information Profile Extension Toxicology Network