Peyronie's disease
| Subclass of | penile disease, fibromatosis  |
|---|---|
| Dem name after | François Gigot de la Peyronie |
| Health specialty | urology |
| Symptoms and signs | erectile dysfunction |
| Genetic association | COL3A1 |
| Risk factor | smoking |
| ICD-9-CM | 607.85 |
Peyronie's disease (PD) be a benign, acquired penile connective tissue disease wey be characterized by de occurrence of fibrotic plaques within de tunica albuginea — de dense elastic covering of de corpora cavernosa. De plaques dey cause abnormal curvature, pain, penile deformities (e.g., narrowing anaa indentation), den usually erectile dysfunction, particularly during erection. De condition typically dey lead to significant sexual den psychological effects, wey dey include difficulty plus penetration den lowered self-esteem anaa evasiveness. Peyronie's disease most often be seen insyd middle-aged den older men plus a median age of onset between 55 den 60 years, however e sanso be common insyd younger individuals den adolescents.[1]
While de etiology of Peyronie's disease still be uncertain, de leading hypothesis be say e dey arise from dysregulated wound healing in response to chronic microtrauma of de erect penis. Dis dey trigger a cascade of profibrotic molecular pathways — most notably overexpression of transforming growth factor-beta 1 (TGF-β1) — wey end insyd fibroblast proliferation, myofibroblast differentiation, den overproduction of type I collagen.[2] Genetic predisposition be supported by family clustering den linkage plus systemic fibrosing disorders such as Dupuytren's contracture.[3] Risk factors dey include age, penile injury, diabetes mellitus, den cigarette smoking.[4][5]
De prevalence of Peyronie's disease be projected at 1% to 20% among de general population of men increasing plus age den comorbidities such as erectile dysfunction (ED) anaa connective tissue disease. While Peyronie's disease neither be infectious nor malignant, e fi get serious negative effects on sexual health den quality of life. E be diagnosed mainly on de clinical presentation wey be supplemented by penile ultrasonography if necessary. Treatment dey depend on de phase den severity of de disease plus conservative measures (e.g., oral therapy, traction, intralesional injection) insyd de milder den stable forms to surgical intervention for de advanced anaa stable ones. Dem name de condition give French surgeon François Gigot de la Peyronie, wey insyd 1743 describe de condition.[6][7]
E be estimated to affect 1–20% of men.[1][6][8] De condition cam be more common plus age.[6][9][10]
References
[edit | edit source]- 1 2 Sandean, Darren P.; Leslie, Stephen W.; Lotfollahzadeh, Saran (2025), "Peyronie Disease", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 32809463, retrieved 2025-10-08
- ↑ Gonzalez-Cadavid, Nestor F.; Rajfer, Jacob (1 June 2005). "Mechanisms of Disease: new insights into the cellular and molecular pathology of Peyronie's disease". Nature Clinical Practice Urology (in English). 2 (6): 291–297. doi:10.1038/ncpuro0201. ISSN 1743-4289. PMID 16474811.
- ↑ Herati, Amin S.; Pastuszak, Alexander W. (1 Jan 2016). "The Genetic Basis of Peyronie Disease: A Review". Sexual Medicine Reviews. 4 (1): 85–94. doi:10.1016/j.sxmr.2015.10.002. ISSN 2050-0521. PMC 4778255. PMID 27872008.
- ↑ Carrieri, M. P.; Serraino, D.; Palmiotto, F.; Nucci, G.; Sasso, F. (1 June 1998). "A case-control study on risk factors for Peyronie's disease". Journal of Clinical Epidemiology. 51 (6): 511–515. doi:10.1016/s0895-4356(98)00015-8. ISSN 0895-4356. PMID 9636000.
- ↑ Bjekic, Milan D.; Vlajinac, Hristina D.; Sipetic, Sandra B.; Marinkovic, Jelena M. (1 March 2003). "Risk factors for Peyronie's disease: a case-control study". BJU International. 97 (3): 570–574. doi:10.1111/j.1464-410X.2006.05969.x. ISSN 1464-4096. PMID 16469028.
- 1 2 3 "Penile Curvature (Peyronie's Disease)". National Institute of Diabetes and Digestive and Kidney Diseases. July 2014. Retrieved 25 October 2017.
- ↑ Levine, Laurence A (2010). "Peyronie's disease and erectile dysfunction: Current understanding and future direction". Indian Journal of Urology. 22 (3): 246–50. doi:10.4103/0970-1591.27633.
- ↑ Moghalu, O.; Pastuszak, A.; Hotaling, J.; Das, R.; Campbell, A.; Horns, J. (2021-03-01). "060 Regional Differences in The Incidence and Prevalence of Peyronie's Disease in The United States - Results from a Claims and Encounters Database". The Journal of Sexual Medicine. 21st Annual Fall Scientific Meeting of SMSNA. 18 (3, Supplement 1): S32 – S33. doi:10.1016/j.jsxm.2021.01.030. ISSN 1743-6095.
- ↑ DiBenedetti, Dana Britt; Nguyen, Dat; Zografos, Laurie; Ziemiecki, Ryan; Zhou, Xiaolei (2011). "A Population-Based Study of Peyronie′s Disease: Prevalence and Treatment Patterns in the United States". Advances in Urology (in English). 2011 (1) 282503. doi:10.1155/2011/282503. ISSN 1687-6377. PMC 3202120. PMID 22110491.
- ↑ Di Maida, Fabrizio; Cito, Gianmartin; Lambertini, Luca; Valastro, Francesca; Morelli, Girolamo; Mari, Andrea; Carini, Marco; Minervini, Andrea; Cocci, Andrea (2021-07-01). "The Natural History of Peyronie's Disease". The World Journal of Men's Health (in English). 39 (3): 399–405. doi:10.5534/wjmh.200065. ISSN 2287-4208. PMC 8255406. PMID 32648381.
External links
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