Physical dependence
| Subclass of | dependence syndrome  |
|---|---|
| NCI Thesaurus ID | C21129 |
Physical dependence be a physical condition wey be caused by chronic use of a tolerance-forming drug, insyd wich abrupt anaa gradual drug withdrawal causes unpleasant physical symptoms.[1][2] Physical dependence fi develop from low-dose therapeutic use of certain medications such as benzodiazepines, opioids, stimulants, antiepileptics den antidepressants, as well as de recreational misuse of drugs such as alcohol, opioids den benzodiazepines. De higher de dose dem use, de greater de duration of use, den de earlier age use dem begin be predictive of worsened physical dependence den thus more severe withdrawal syndromes. Acute withdrawal syndromes fi last days, weeks anaa months. Protracted withdrawal syndrome, dem sanso know as post-acute-withdrawal syndrome anaa "PAWS", be a low-grade continuation of sam of de symptoms of acute withdrawal, typically insyd a remitting-relapsing pattern, often dey result in relapse den prolonged disability of a degree to preclude de possibility of lawful employment. Protracted withdrawal syndrome fi last for months, years, anaa dey depend on individual factors, indefinitely. Protracted withdrawal syndrome be noted to be most often be caused by benzodiazepines as well as opioids.[3] To dispel de popular misassociation plus addiction, physical dependence to medications be sam times compared to dependence on insulin by persons plus diabetes.[4]
References
[edit | edit source]- ↑ "Definition of physical dependence - NCI Dictionary of Cancer Terms". 2011-02-02. Retrieved 2015-02-18.
- ↑ "All about Addiction". Medical News Today. Retrieved 2015-02-18.
- ↑ Landry MJ, Smith DE, McDuff DR, Baughman OL (1992). "Benzodiazepine dependence and withdrawal: identification and medical management". J Am Board Fam Pract. 5 (2): 167–75. PMID 1575069.
- ↑ "Withdrawal From Antidepressants: Symptoms, Causes, Treatments". WebMD (in American English). Retrieved 2016-02-20.
These symptoms are not technically the same thing as physical "withdrawal" from a drug.... Unlike drug withdrawal, antidepressant discontinuation effects are not related to addiction but can reflect physiological consequences of stopping a drug, just as when someone with diabetes stops insulin.