Pick's disease
Pick disease
| Subclass of | neurodegeneration, frontotemporal dementia, cerebral degeneration, disease  |
|---|---|
| Dem name after | Arnold Pick |
| Health specialty | neurology |
| Genetic association | PSEN1, MAPT |
| ICD-9-CM | 331.11 |
| NCI Thesaurus ID | C85008 |
Behavioral variant frontotemporal dementia (BvFTD) na dem previously know as Pick's disease, wey e be de most common of de FTD types.[1][2] BvFTD be diagnosed four times as often as de PPA variants.[3] Behavior fi change insyd BvFTD insyd either of two ways—e fi change to e be impulsive den disinhibited, dey act insyd socially unacceptable ways; anaa e fi change to e be listless den apathetic.[4][5] About 12–13% of people plus bvFTD dey develop motor neuron disease.[6]
De Pick bodies wich be present insyd behavioral variant FTD be spherical inclusion bodies dem find insyd de cytoplasm of affected cells. Dem dey consist of tau fibrils as a major component togeda plus a number of oda protein products wey dey include ubiquitin den tubulin.[7]
References
[edit | edit source]- ↑ "What are the Different Types of Frontotemporal Disorders?". National Institute on Aging (in English). Archived from the original on July 28, 2017. Retrieved 1 November 2020.
- ↑ "What is frontotemporal dementia". Dementia UK. Retrieved 2020-10-19.
- ↑ Olney NT, Spina S, Miller BL (May 2017). "Frontotemporal Dementia". Neurologic Clinics. 35 (2): 339–374. doi:10.1016/j.ncl.2017.01.008. PMC 5472209. PMID 28410663.
- ↑ "Frontotemporal Dementia Information Page". National Institute of Neurological Disorders and Stroke. U.S. National Institutes of Health.
- ↑ Sleegers K, Cruts M, Van Broeckhoven C (2010). "Molecular pathways of frontotemporal lobar degeneration". Annual Review of Neuroscience. 33 (1): 71–88. doi:10.1146/annurev-neuro-060909-153144. PMID 20415586.
- ↑ Bang J, Spina S, Miller BL (October 2015). "Frontotemporal dementia". Lancet. 386 (10004): 1672–1682. doi:10.1016/S0140-6736(15)00461-4. PMC 5970949. PMID 26595641.
- ↑ Gaillard F. "Pick bodies". Radiology Reference Article. Radiopaedia. Retrieved 12 March 2021.
External links
[edit | edit source]
Pick's disease at Wikipedia's sister projects
- "AFTD - The Association for Frontotemporal Degeneration" (in American English). Retrieved 2025-05-15. Patient group