Prednisone
| Subclass of | steroid  |
|---|---|
| Get use | Medication |
| Stylized name | predniSONE |
| Chemical formula | C₂₁H₂₆O₅ |
| Canonical SMILES | CC12CC(=O)C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C |
| Isomeric SMILES | C[C@]12CC(=O)[C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C |
| Active ingredient in | Deltasone, Rayos |
| World Health Organisation international non-proprietary name | prednisone |
| Physically dey interact plus | Nuclear receptor subfamily 3 group C member 1 |
| Get characteristic | bitterness |
| Subject has role | 5-lipoxygenase inhibitor, selective glucocorticoid receptor agonist, anti-inflammatory agent, glucocorticoid, hormonal antineoplastic agent |
Prednisone be a glucocorticoid medication dem mostly use to suppress de immune system den decrease inflammation insyd conditions such as asthma, COPD, den rheumatologic diseases.[1] E sanso be used to treat high blood calcium secof cancer den adrenal insufficiency along plus oda corticosteroids.[1] Dem dey take am by mouth.[1]
Common side effects fi include cataracts, bone loss, easy bruising, muscle weakness, den thrush.[1] Oda side effects dey include weight gain, swelling, high blood sugar, increased risk of infection, den psychosis.[1][2] E be generally considered safe insyd pregnancy den low doses dey appear to be safe while de user dey breastfeed.[3] After prolonged use, prednisone for be stopped gradually.[1]
Prednisone be a prodrug wey e for be converted to prednisolone by de liver before e cam be active.[4][5] Prednisolone then dey bind to glucocorticoid receptors, wey dey activate dem den dey trigger changes insyd gene expression.[2] Dese changes dey inhibit function den decrease de number of key leukocytes insyd de bloodstream.[6]
Na dem patent prednisone insyd 1954 wey na dem approve for medical use insyd de United States insyd 1955.[1][7] Prednisone be a therapeutic alternative on de World Health Organization's List of Essential Medicines.[8] E be available as a generic medication.[1] Insyd 2023, na e be de 38th most commonly prescribed medication insyd de United States, plus more dan 15 million prescriptions.[9][10]
References
[edit | edit source]- 1 2 3 4 5 6 7 8 "Prednisone Monograph for Professionals". Drugs.com. AHFS. Retrieved 24 December 2018.
- 1 2 Brunton L (2017). Goodman & Gilman's the pharmacological basis of therapeutics (13 ed.). McGraw-Hill Education. pp. 739, 746, 1237. ISBN 978-1-25-958473-2.
- ↑ "Prednisone Use During Pregnancy". Drugs.com. Retrieved 24 December 2018.
- ↑ "Product Information Panafcort (prednisone) Panafcortelone (prednisolone)" (PDF). TGA eBusiness Services. St Leonards, Australia: Aspen Pharmacare Australia Pty Ltd. 11 July 2017. pp. 1–2. Retrieved 30 June 2018.
- ↑ Buttgereit F, Gibofsky A (June 2013). "Delayed-release prednisone - a new approach to an old therapy". Expert Opinion on Pharmacotherapy. 14 (8): 1097–1106. doi:10.1517/14656566.2013.782001. PMID 23594208. S2CID 22720230.
- ↑ PMC, Europe. "Europe PMC". europepmc.org (in English). Retrieved 2025-11-14.
- ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 485. ISBN 9783527607495.
- ↑ World Health Organization (2025). The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines, 24th list. Geneva: World Health Organization. hdl:10665/382243.
- ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
- ↑ "Prednisone Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 13 August 2025.
External links
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