Jump to content

Pregabalin

From Wikipedia
pregabalin
type of chemical entity
Subclass of3-(Aminomethyl)-5-methylhexanoic acid Edit
Get useMedication Edit
Stereoisomer ofCHEMBL167003 Edit
Chemical formulaC₈H₁₇NO₂ Edit
Canonical SMILESCC(C)CC(CC(=O)O)CN Edit
Isomeric SMILESCC(C)C[C@@H](CC(=O)O)CN Edit
World Health Organisation international non-proprietary namepregabalin Edit
Pregnancy categoryAustralian pregnancy category B3, US pregnancy category C Edit
LiverTox likelihood scoreLiverTox toxicity likelihood category C Edit
Subject has roleanalgesic, anticonvulsant agent, calcium channel blocker, anxiolytic Edit

Pregabalin, dem sell under de brand name Lyrica among odas, be an anticonvulsant, analgesic, den anxiolytic amino acid medication dem use to treat epilepsy, neuropathic pain, fibromyalgia, restless legs syndrome, opioid withdrawal, generalized anxiety disorder (GAD), den shingles.[1][2][3][4] Pregabalin sanso get antiallodynic properties.[5][6][7] Ein use insyd epilepsy be as an add-on therapy give partial seizures.[1] Wen dem use before surgery, e dey reduce pain buh dey result in greater sedation den visual disturbances.[8] Dem dey take am by mouth.[1]

Common side effects fi include headache, dizziness, sleepiness, euphoria, confusion, trouble plus memory, poor coordination, dry mouth, problems plus vision, den weight gain.[1][9] Serious side effects fi include angioedema, kidney damage, den seizures.[1][10]

As plus all oda drugs dem approve by de FDA for treating epilepsy, de pregabalin labeling dey warn of an increased suicide risk wen dem combine plus oda drugs.[1][11] Wen dem take pregabalin at high doses over a long period of time, addiction fi occur, buh if dem take am at usual doses de risk be low.[12] Ein use during pregnancy anaa breastfeeding be of unclear safety.[13]

E be a gabapentinoid medication wich be a class of drugs within de derivatives of γ-aminobutyric acid (GABA analogues), an inhibitory neurotransmitter.[14][15][16][17] Although pregabalin be inactive at GABA receptors den GABA synapses, e dey act by binding specifically to de α2δ-1 protein wey na dem first describe as an auxiliary subunit of voltage-gated calcium channels.[1][18][19]

Na dem approve pregabalin for medical use insyd de United States insyd 2004.[1] Insyd de US, pregabalin be a Schedule V controlled substance under de Controlled Substances Act of 1970,[1] wich dey mean say de drug get low abuse potential compared to substances insyd Schedules I-IV, however, der still be a potential for misuse.[20] E be available as a generic medication.[9][21][22][23][24] Insyd 2023, na e be de 78th most commonly prescribed medication insyd de United States, plus more dan 8 million prescriptions.[25][26]

References

[edit | edit source]
  1. 1 2 3 4 5 6 7 8 9 "Pregabalin". The American Society of Health-System Pharmacists. Archived from the original on December 2, 2019. Retrieved February 3, 2019.
  2. ↑ Frampton JE (September 2014). "Pregabalin: a review of its use in adults with generalized anxiety disorder". CNS Drugs. 28 (9): 835–854. doi:10.1007/s40263-014-0192-0. PMID 25149863. S2CID 5349255.
  3. ↑ Iftikhar IH, Alghothani L, Trotti LM (December 2017). "Gabapentin enacarbil, pregabalin and rotigotine are equally effective in restless legs syndrome: a comparative meta-analysis". European Journal of Neurology. 24 (12): 1446–1456. doi:10.1111/ene.13449. PMID 28888061. S2CID 22262972.
  4. ↑ Schmader K, Dworkin RH (January 1, 2018). "Chapter 28 - Herpes Zoster and Postherpetic Neuralgia". In Benzon HT, Raja SN, Liu SS, Fishman SM (eds.). Essentials of Pain Medicine (Fourth ed.). Elsevier. pp. 233–240.e2. doi:10.1016/b978-0-323-40196-8.00028-0. ISBN 978-0-323-40196-8.
  5. ↑ Wyllie E, Cascino GD, Gidal BE, Goodkin HP (February 17, 2012). Wyllie's Treatment of Epilepsy: Principles and Practice. Lippincott Williams & Wilkins. p. 423. ISBN 978-1-4511-5348-4.
  6. ↑ Kirsch D (October 10, 2013). Sleep Medicine in Neurology. John Wiley & Sons. p. 241. ISBN 978-1-118-76417-6.
  7. ↑ Frye M, Moore K (2009). "Gabapentin and Pregabalin". In Schatzberg AF, Nemeroff CB (eds.). The American Psychiatric Publishing Textbook of Psychopharmacology. pp. 767–77. doi:10.1176/appi.books.9781585623860.as38. ISBN 978-1-58562-309-9. Archived from the original on February 27, 2024. Retrieved September 1, 2022.
  8. ↑ Mishriky BM, Waldron NH, Habib AS (January 2015). "Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis". British Journal of Anaesthesia. 114 (1): 10–31. doi:10.1093/bja/aeu293. PMID 25209095.
  9. 1 2 British National Formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 323. ISBN 978-0-85711-338-2.
  10. ↑ Oskouei, Zahra; Moshiri, Mohammad; Raouf-Rahmati, Amene; Nemati, Ahmad; Bemani Naeini, Mehri; Jomehpour, Hamid; Roohbakhsh, Ali; Salmasi, Zahra; Etemad, Leila (2025-02-08). "Seizures as an Adverse Effect of Pregabalin Consumption: A Systematic Review". Addiction and Health (in English). 17: 1527. doi:10.34172/ahj.1527. ISSN 2008-4633. PMC 12128000. PMID 40458269.
  11. ↑ Britton JW, Shih JJ (2010). "Antiepileptic drugs and suicidality". Drug, Healthcare and Patient Safety. 2: 181–189. doi:10.2147/DHPS.S13225. PMC 3108698. PMID 21701630.
  12. ↑ Schifano F (June 2014). "Misuse and abuse of pregabalin and gabapentin: cause for concern?". CNS Drugs. 28 (6): 491–496. doi:10.1007/s40263-014-0164-4. PMID 24760436.
  13. ↑ "Pregabalin Use During Pregnancy". Drugs.com. Archived from the original on March 21, 2019. Retrieved February 4, 2019.
  14. ↑ Calandre EP, Rico-Villademoros F, Slim M (2016). "Alpha2delta ligands, gabapentin, pregabalin and mirogabalin: a review of their clinical pharmacology and therapeutic use". Expert Rev Neurother. 16 (11): 1263–1277. doi:10.1080/14737175.2016.1202764. PMID 27345098. S2CID 33200190.
  15. ↑ Dooley DJ, Taylor CP, Donevan S, Feltner D (2007). "Ca2+ channel alpha2delta ligands: novel modulators of neurotransmission". Trends Pharmacol. Sci. 28 (2): 75–82. doi:10.1016/j.tips.2006.12.006. PMID 17222465.
  16. ↑ Elaine Wyllie; Gregory D. Cascino; Barry E. Gidal; Howard P. Goodkin (February 17, 2012). Wyllie's Treatment of Epilepsy: Principles and Practice. Lippincott Williams & Wilkins. p. 423. ISBN 978-1-4511-5348-4.
  17. ↑ Honorio Benzon; James P. Rathmell; Christopher L. Wu; Dennis C. Turk; Charles E. Argoff; Robert W Hurley (September 11, 2013). Practical Management of Pain. Elsevier Health Sciences. p. 1006. ISBN 978-0-323-17080-2.
  18. ↑ Calandre EP, Rico-Villademoros F, Slim M (November 2016). "Alpha2delta ligands, gabapentin, pregabalin and mirogabalin: a review of their clinical pharmacology and therapeutic use". Expert Review of Neurotherapeutics. 16 (11): 1263–1277. doi:10.1080/14737175.2016.1202764. PMID 27345098. S2CID 33200190.
  19. ↑ Uchitel OD, Di Guilmi MN, Urbano FJ, Gonzalez-Inchauspe C (2010). "Acute modulation of calcium currents and synaptic transmission by gabapentinoids". Channels. 4 (6): 490–496. doi:10.4161/chan.4.6.12864. hdl:11336/20897. PMID 21150315.
  20. ↑ "Is Lyrica a Controlled Substance?". Archived from the original on May 6, 2024. Retrieved May 6, 2024.
  21. ↑ "Generic Lyrica Availability". Drugs.com. Archived from the original on March 27, 2019. Retrieved February 4, 2019.
  22. ↑ "FDA approves first generics of Lyrica". U.S. Food and Drug Administration (FDA) (Press release). September 11, 2019. Archived from the original on June 9, 2020. Retrieved October 27, 2019.
  23. ↑ "Pregabalin ER: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on June 24, 2021. Retrieved June 19, 2021.
  24. ↑ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). June 29, 2023. Archived from the original on June 29, 2023. Retrieved June 29, 2023.
  25. ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  26. ↑ "Pregabalin Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved August 18, 2025.
[edit | edit source]
Dem retrieve am from "https://gpe.wikipedia.org/w/index.php?title=Pregabalin&oldid=83273"