Progressive supranuclear palsy
| Dem name after | John C. Steele, Jerzy Olszewski  |
|---|---|
| Health specialty | neurology |
| External data available at URL | http://www.nanbyou.or.jp/entry/4114 |
| ICD-9-CM | 333.0 |
Progressive supranuclear palsy (PSP) be a non late-onset neurodegenerative disease wey dey involve de gradual deterioration den death of specific volumes of de brain, dem link to 4-repeat tau pathology.[1][2][3] De condition dey lead to symptoms wey dey include loss of balance, slowing of movement, difficulty dey move de eyes, den cognitive impairment.[1] PSP fi be mistaken for oda types of neurodegeneration such as Parkinson's disease, frontotemporal dementia den Alzheimer's disease. E be de second most common tauopathy behind Alzheimer's disease. De cause of de condition be uncertain, buh dey involve de accumulation of tau protein within de brain. Medications such as levodopa den amantadine fi be useful insyd sam cases.[1]
Na dem first describe PSP by Richardson, Steele, den Olszewski insyd 1963 as a form of progressive parkinsonism.[4] However, de earliest known case wey dey present clinical dey feature consistent plus PSP, along plus pathological confirmation, na dem report insyd France insyd 1951.[5] Originally dem think am to be a more general type of atypical parkinsonism, PSP be linked to distinct clinical phenotypes wey dey include PSP-Richardson's syndrome (PSP-RS), wich be de most common sub-type of de disease.[6] As PSP dey advance to a fully symptomatic stage, chaw PSP subtypes eventually dey exhibit de clinical characteristics of PSP-RS.[3]
PSP of all phenotypes get a prevalence of 18 per 100,000, whereas PSP-RS dey affect approximately 5 to 7 per 100,000 individuals.[1][3] De first symptoms typically dey occur at 60–70 years of age. Males slightly be more susceptible dan females.[1] Na dem no find association between PSP den any particular race, location, anaa occupation.[1]
Society den culture
[edit | edit source]Der be several organizations around de world wey dey support PSP patients den de research into PSP den related diseases, such as corticobasal degeneration (CBD) den multiple system atrophy (MSA).
- Canada: PSP Society of Canada[7]
- France: Association PSP France, a nonprofit patient association dem set up insyd 1996[8]
- UK: PSPA, a national charity for information, patient support den research of PSP den CBD, dem set up insyd 1994[9]
- Ireland: PSPAI, an organization wich dey aim to increase public awareness of PSP[10]
- US: CurePSP, a nonprofit organization for promoting awareness, care den research of PSP, CBD, MSA "den oda prime of life neurodegenerative diseases"[11]
Insyd popular culture
[edit | edit source]Insyd de 2020 American musical comedy-drama television series, Zoey's Extraordinary Playlist, de title character ein poppie (Mitch Clarke, wey Peter Gallagher play) get PSP.[12]
Notable cases
[edit | edit source]- Dudley Moore (1935–2002): English actor, comedian, musician den composer
- Peter Sarstedt (1941–2017): English singer den songwriter
- Jesse Jackson (1941–2026) American activist
- Phyllis Frelich (1944–2014): American Tony Award-winning actor
- Richard Rainwater (1944–2015): American investor den philanthropist
- Mary McCaslin (1946–2022): American singer den songwriter
- Linda Ronstadt (b. 1946): American singer[13]
- Veena Sahasrabuddhe (1948–2016): Indian classical vocalist[14]
- Jeff Golub (1955–2015): American Rock den Jazz guitar musician
- Lee Wei Ling (1955–2024): Singaporean neurologist[15]
- Jennifer Wexton (b. 1968): former US Representative[16]
References
[edit | edit source]- 1 2 3 4 5 6 Golbe LI (April 2014). "Progressive supranuclear palsy". Seminars in Neurology. 34 (2): 151–9. doi:10.1055/s-0034-1381736. PMID 24963674.
- ↑ "ICD-11 - Mortality and Morbidity Statistics". icd.who.int.
- 1 2 3 Boxer, Adam L; Yu, Jin-Tai; Golbe, Lawrence I; Litvan, Irene; Lang, Anthony E; Höglinger, Günter U (July 2017). "Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches". The Lancet Neurology (in English). 16 (7): 552–563. doi:10.1016/S1474-4422(17)30157-6. PMC 5802400. PMID 28653647.
- ↑ Lopez, G.; Bayulkem, K.; Hallett, M. (October 2016). "Progressive supranuclear palsy (PSP): Richardson syndrome and other PSP variants". Acta Neurologica Scandinavica (in English). 134 (4): 242–249. doi:10.1111/ane.12546. PMC 7292631. PMID 27070344.
- ↑ Brusa, Adolfo; Stoehr, Rolf; Pramstaller, Peter P. (March 2004). "Progressive supranuclear palsy: New disease or variant of postencephalitic parkinsonism?". Movement Disorders (in English). 19 (3): 247–252. doi:10.1002/mds.10699. ISSN 0885-3185. PMID 15022178.
- ↑ Coughlin, David G.; Litvan, Irene (April 2020). "Progressive supranuclear palsy: Advances in diagnosis and management". Parkinsonism & Related Disorders (in English). 73: 105–116. doi:10.1016/j.parkreldis.2020.04.014. PMC 7462164. PMID 32487421.
- ↑ PSP Society of Canada, re-linked 2020-01-20
- ↑ PSP France - Notre histoire Archived 2020-06-05 at the Wayback Machine, re-linked 2020-01-20
- ↑ "About us". PSPA. Retrieved 7 July 2025.
- ↑ "What is PSP". 18 October 2013.
- ↑ CurePSP, re-linked 2020-01-20
- ↑ Bentley, Jean (May 3, 2020). "'Zoey's Extraordinary Playlist' Boss on That Devastating Finale and Season 2 Plans". The Hollywood Reporter (in English). Retrieved 2020-05-04.
- ↑ Schulman, Michael (September 1, 2019). "Linda Ronstadt Has Found Another Voice". The New Yorker (in English).
- ↑ Inamdar, Nikhil (July 7, 2016). "Veena Sahasrabuddhe, Vocalist Who Stood at the Threshold of True Glory". The Wire (in English).
- ↑ Tham, Yuen-C; Mujibah, Fatimah (2024-10-09). "Lee Wei Ling, Lee Kuan Yew's daughter, dies at 69". The Straits Times (in English). ISSN 0585-3923. Retrieved 2024-10-09.
- ↑ Portnoy, Jenna (18 September 2023). "Rep. Jennifer Wexton will not seek reelection as diagnosis changes". Washington Post.
External links
[edit | edit source]