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Propofol

From Wikipedia
propofol
type of chemical entity
Subclass ofchemical compound Edit
Get useMedication Edit
Chemical formulaC₁₂H₁₈O Edit
Canonical SMILESCC(C)C1=C(C(=CC=C1)C(C)C)O Edit
Active ingredient inDiprivan Edit
World Health Organisation international non-proprietary namepropofol, propofolum Edit
Medical condition treatedpain, agitation in dementia, status epilepticus, subacute delirium, anaesthesia Edit
Physically dey interact plusHyperpolarization activated cyclic nucleotide gated potassium channel 1 Edit
Pregnancy categoryAustralian pregnancy category C, US pregnancy category B Edit
ManufacturerPfizer Edit
Subject has roleGABAA receptor positive allosteric modulators, hypnotics and sedatives, intravenous anesthetics, essential medicine Edit

Propofol[1] be de active component of an intravenous anesthetic formulation dem use for induction den maintenance of general anesthesia. Na dem approve de formulation under de brand name Diprivan. Na dem since release chaw generic versions. Dem use intravenous administration to induce unconsciousness, after wich dem fi maintain anesthesia dey use a combination of medications. Na dem manufacture am as part of a sterile injectable emulsion formulation dey use soybean oil den lecithin, wey dey give am a white milky coloration.[2]

Dem compare to oda anesthetic agents, recovery from propofol-induced anesthesia generally be rapid wey be associated plus less frequent side effects[3][4] (e.g., drowsiness, nausea, vomiting). Dem fi use propofol prior to diagnostic procedures wey dey require anesthesia, insyd de management of refractory status epilepticus, den for induction anaa maintenance of anesthesia prior to den during surgeries. E fi be administered as a bolus anaa an infusion, anaa as a combination of de two.

Dem first synthesize am insyd 1973 by John B. Glen, a British veterinary anesthesiologist wey dey work give Imperial Chemical Industries (ICI, later AstraZeneca),[5] na dem introduce propofol for therapeutic use as a lipid emulsion insyd de United Kingdom den New Zealand insyd 1986. Na propofol (Diprivan) receive FDA approval insyd October 1989. E be on de World Health Organization's List of Essential Medicines.[6]

References

[edit | edit source]
  1. ↑ "Propofol". PubChem. U.S. National Library of Medicine. Retrieved 25 October 2023.
  2. ↑ "Making Stable, Sterile Propofol". www.microfluidics-mpt.com. Retrieved 25 October 2023.
  3. ↑ "Propofol". go.drugbank.com. Retrieved 25 October 2023.
  4. ↑ Glen JB (September 2018). "The Discovery and Development of Propofol Anesthesia: The 2018 Lasker-DeBakey Clinical Medical Research Award". JAMA. 320 (12): 1235–1236. doi:10.1001/jama.2018.12756. PMID 30208399.
  5. ↑ Glen JB (July 2019). "Try, try, and try again: personal reflections on the development of propofol". British Journal of Anaesthesia. 123 (1): 3–9. doi:10.1016/j.bja.2019.02.031. PMID 30982566.
  6. ↑ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
[edit | edit source]
  • GB patent 1472793, John B. Glen; Roger James & Bob-James Munroe, "Pharmaceutical Compositions", published 1977-05-04, assigned to Imperial Chemical Industries Ltd  Archived 5 June 2021 at the Wayback Machine
Dem retrieve am from "https://gpe.wikipedia.org/w/index.php?title=Propofol&oldid=81886"