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Quetiapine

From Wikipedia
quetiapine
type of chemical entity
Subclass ofatypical antipsychotic, heterocyclic compound, alcohols Edit
Part ofresponse to quetiapine Edit
Get useMedication Edit
Stylized nameQUEtiapine, SEROquel Edit
Chemical formulaC₂₁H₂₅N₃O₂S Edit
Canonical SMILESC1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42 Edit
Active ingredient inSeroquel Edit
World Health Organisation international non-proprietary namequetiapine Edit
Legal status (medicine)boxed warning Edit
Pregnancy categoryAustralian pregnancy category B3, US pregnancy category C Edit
LiverTox likelihood scoreLiverTox toxicity likelihood category B Edit
Subject has rolealpha blocker, dopamine antagonist, serotonin antagonist, H1 antagonist Edit

Quetiapine, dem sell under de brand name Seroquel among odas, be an atypical antipsychotic medication dem use insyd de treatment of schizophrenia, bipolar disorder, bipolar depression, den major depressive disorder.[1][2] Despite e be widely prescribed as a sleep aid secof ein tranquillizing effects, de benefits of such use no fi outweigh de risk of undesirable side effects.[3] Dem dey take am orally.[1]

Common side effects dey include sedation, fatigue, weight gain, constipation, den dry mouth.[1] Oda side effects dey include low blood pressure plus standing, seizures, high blood sugar, tardive dyskinesia, den neuroleptic malignant syndrome.[1] Insyd older people plus dementia, ein use dey increase de risk of death.[1] Ein use insyd de third trimester of pregnancy fi result insyd a movement disorder insyd de baby for sam time after birth.[1] Dem dey believe quetiapine dey work by blocking a number of receptors, wey dey include those for serotonin den dopamine.[1]

Na dem develop quetiapine insyd 1985 wey na dem approve for medical use insyd de United States insyd 1997.[1][4][5] E be available as a generic medication.[6] Insyd 2023, na e be de most prescribed antipsychotic den 60th most commonly prescribed medication insyd de United States, plus more dan 10 million prescriptions.[7][8] E be on de World Health Organization's List of Essential Medicines.[9]

De drug be typically among two antipsychotics (de oda be olanzapine) to have superior efficacy for de treatment of bipolar disorder. Quetiapine be one of two antipsychotics per (de oda be cariprazine) wey dey produce equal efficacy as standalone therapies for mixed manic-depressive mood swings as dem dey do in combination plus an SSRI antidepressant. Buh e be less potent than clozapine, amisulpride, olanzapine, risperidone, den paliperidone in alleviating psychotic symptoms anaa treating schizophrenia.

References

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  1. 1 2 3 4 5 6 7 8 "Quetiapine Fumarate". The American Society of Health-System Pharmacists. Archived from the original on 29 August 2017. Retrieved 26 March 2017.
  2. ↑ Komossa K, Depping AM, Gaudchau A, Kissling W, Leucht S (December 2010). "Second-generation antipsychotics for major depressive disorder and dysthymia". The Cochrane Database of Systematic Reviews. 2012 (12) CD008121. doi:10.1002/14651858.CD008121.pub2. PMC 11994262. PMID 21154393.
  3. ↑ Anderson SL, Vande Griend JP (March 2014). "Quetiapine for insomnia: A review of the literature" (PDF). American Journal of Health-System Pharmacy. 71 (5): 394–402. doi:10.2146/ajhp130221. PMID 24534594. S2CID 207292819. Archived from the original (PDF) on 19 February 2020.
  4. ↑ "Seroquel- quetiapine tablet, film coated". DailyMed. 27 January 2022. Retrieved 22 September 2024.
  5. ↑ Riedel M, Müller N, Strassnig M, Spellmann I, Severus E, Möller HJ (April 2007). "Quetiapine in the treatment of schizophrenia and related disorders". Neuropsychiatric Disease and Treatment. 3 (2): 219–235. doi:10.2147/nedt.2007.3.2.219. PMC 2654633. PMID 19300555.
  6. ↑ British national formulary: BNF 74 (74 ed.). British Medical Association. 2017. p. 383. ISBN 978-0-85711-298-9.
  7. ↑ "The Top 300 of 2023". clincalc.com. Archived from the original on 2025-08-12. Retrieved 2025-08-13.
  8. ↑ "Quetiapine - Drug Usage Statistics, ClinCalc DrugStats Database". clincalc.com. Retrieved 2025-08-13.
  9. ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
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